USE OF MODIFIED TETHERS IN SCREENING COMPOUND LIBRARIES
    1.
    发明申请
    USE OF MODIFIED TETHERS IN SCREENING COMPOUND LIBRARIES 审中-公开
    在编辑复合图书馆中使用修改后的四方

    公开(公告)号:WO1998025146A1

    公开(公告)日:1998-06-11

    申请号:PCT/GB1997003303

    申请日:1997-12-01

    Abstract: The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.

    Abstract translation: 本发明提供了筛选具有所需性质,特别是激动,结合或拮抗细胞受体的能力的化合物的复合物文库的方法。 这些文库中的络合物包括被测化合物,记录化合物合成中至少一个步骤的标签,以及易受报道分子修饰的系链。 系链的修饰用于表示复合物含有具有所需性质的化合物。 可以对标签进行解码以显示合成这种化合物的至少一个步骤。

    HUMAN ORGANIC SOLUTE TRANSPORTERS
    3.
    发明申请
    HUMAN ORGANIC SOLUTE TRANSPORTERS 审中-公开
    人体有机解决方案

    公开(公告)号:WO2004033655A2

    公开(公告)日:2004-04-22

    申请号:PCT/US2003/032087

    申请日:2003-10-08

    IPC: C12N

    CPC classification number: C07K14/47

    Abstract: The invention provides several new transporter proteins, nucleic acids encoding them and methods of using the transporters to screen agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the transporters. The invention also provides methods of treatment involving oral delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of one of the transporter.

    Abstract translation: 本发明提供几种新的转运蛋白,编码它们的核酸和使用转运蛋白筛选与试剂连接或可连接的试剂,缀合物或缀合物部分,以及通过转运蛋白作为底物转运的能力的方法。 本发明还提供涉及口服递送药物的方法,所述药物单独或作为与缀合物部分连接的结果是转运蛋白之一的底物。

    HUMAN ORGANIC SOLUTE TRANSPORTERS
    6.
    发明申请
    HUMAN ORGANIC SOLUTE TRANSPORTERS 审中-公开
    人类有机溶质转运蛋白

    公开(公告)号:WO2005070961A1

    公开(公告)日:2005-08-04

    申请号:PCT/US2005/002333

    申请日:2005-01-24

    CPC classification number: C07K14/47 C07K14/705 G01N33/6872

    Abstract: The invention provides several new transporter proteins, nucleic acids encoding them and methods of using the transporters to screen agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the transporters. The invention also provides methods of treatment involving oral delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of one of the transporter.

    Abstract translation: 本发明提供了几种新的转运蛋白,编码它们的核酸以及使用转运蛋白筛选连接或可连接于试剂的试剂,缀合物或缀合物部分以便作为底物通过 转运。 本发明还提供了涉及经口递送试剂的治疗方法,所述试剂单独或作为与缀合物部分连接的结果是转运蛋白之一的底物。

    HUMAN ORGANIC SOLUTE TRANSPORTERS
    8.
    发明申请
    HUMAN ORGANIC SOLUTE TRANSPORTERS 审中-公开
    人体有机解决方案

    公开(公告)号:WO2004033655A3

    公开(公告)日:2005-06-23

    申请号:PCT/US0332087

    申请日:2003-10-08

    CPC classification number: C07K14/47

    Abstract: The invention provides several new transporter proteins, nucleic acids encoding them and methods of using the transporters to screen agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the transporters. The invention also provides methods of treatment involving oral delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of one of the transporter.

    Abstract translation: 本发明提供几种新的转运蛋白,编码它们的核酸和使用转运蛋白筛选与试剂连接或可连接的试剂,缀合物或缀合物部分,以及通过转运蛋白作为底物转运的能力的方法。 本发明还提供涉及口服递送药物的方法,所述药物单独或作为与缀合物部分连接的结果是转运蛋白之一的底物。

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