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公开(公告)号：WO1998025146A1
公开(公告)日：1998-06-11
申请号：PCT/GB1997003303
申请日：1997-12-01
Applicant: GLAXO GROUP LIMITED , DOWER, William, James , HEINKEL, Gregory, Lynn , MATTHEAKIS, Larry, Costas , SCHATZ, Peter, Joseph , LALONDE, Guy , PADDON, Christopher, John , GATES, Christian, M.
Inventor： GLAXO GROUP LIMITED
IPC: G01N33/58
CPC classification number: G01N33/566 , C40B40/00 , G01N33/532 , G01N33/54306 , G01N2500/00
Abstract: The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
Abstract translation: 本发明提供了筛选具有所需性质，特别是激动，结合或拮抗细胞受体的能力的化合物的复合物文库的方法。 这些文库中的络合物包括被测化合物，记录化合物合成中至少一个步骤的标签，以及易受报道分子修饰的系链。 系链的修饰用于表示复合物含有具有所需性质的化合物。 可以对标签进行解码以显示合成这种化合物的至少一个步骤。
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公开(公告)号：WO2007140339A8
公开(公告)日：2007-12-06
申请号：PCT/US2007/069807
申请日：2007-05-25
Applicant: AMYRIS BIOTECHNOLOGIES, INC. , RENNINGER, Neil, Stephen , NEWMAN, Jack , REILING, Keith, Kinkead , REGENTIN, Rika , PADDON, Christopher, John
Inventor： RENNINGER, Neil, Stephen , NEWMAN, Jack , REILING, Keith, Kinkead , REGENTIN, Rika , PADDON, Christopher, John
Abstract: The present invention provides methods for a robust production of isoprenoids via one or more biosynthetic pathways. The invention also provides nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods. The invention also provides fermentation methods for high productivity of isoprenoids from genetically modified host cells.
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公开(公告)号：WO2004033655A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/032087
申请日：2003-10-08
Applicant: XENOPORT, INC. , ZERANGUE, Noa , PADDON, Christopher
Inventor： ZERANGUE, Noa , PADDON, Christopher
IPC: C12N
CPC classification number: C07K14/47
Abstract: The invention provides several new transporter proteins, nucleic acids encoding them and methods of using the transporters to screen agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the transporters. The invention also provides methods of treatment involving oral delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of one of the transporter.
Abstract translation: 本发明提供几种新的转运蛋白，编码它们的核酸和使用转运蛋白筛选与试剂连接或可连接的试剂，缀合物或缀合物部分，以及通过转运蛋白作为底物转运的能力的方法。 本发明还提供涉及口服递送药物的方法，所述药物单独或作为与缀合物部分连接的结果是转运蛋白之一的底物。
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公开(公告)号：WO2011064194A1
公开(公告)日：2011-06-03
申请号：PCT/EP2010/067995
申请日：2010-11-23
Applicant: SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. , PADDON, Christopher, Andrew , SONG, Wei , WEDLOCK, David, John , WHITMIRE, Carol, Perkins
Inventor： PADDON, Christopher, Andrew , SONG, Wei , WHITMIRE, Carol, Perkins
IPC: C10M169/04 , C10M171/02 , C10N30/02 , C10N20/02 , C10N40/04
CPC classification number: C10M169/04 , C10M171/02 , C10M2205/173 , C10N2220/022 , C10N2220/025 , C10N2230/02 , C10N2240/042 , C10M2205/02
Abstract: The present invention provides an additive concentrate comprising: - at least 90 wt. % of a Fischer-Tropsch derived base oil, based on the total weight of the additive concentrate; - at least 3.0 wt. % of a viscosity modifier, based on the total weight of the additive concentrate; and - less than 5.0 wt. % of a solvency booster, based on the total weight of the additive concentrate.
Abstract translation: 本发明提供一种添加剂浓缩物，其包含：至少90wt。 基于添加剂浓缩物的总重量的费 - 托衍生的基础油的％; - 至少3.0重量％ 基于添加剂浓缩物的总重量的粘度调节剂的％; 和 - 小于5.0wt。 基于添加剂浓缩物的总重量的溶剂增效剂的百分比。
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公开(公告)号：WO2007140339A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069807
申请日：2007-05-25
Applicant: AMYRIS BIOTECHNOLOGIES INC , RENNINGER NEIL STEPHEN , NEWMAN JACK , REILING KEITH KINKEAD , REGENTIN RIKA , PADDON CHRISTOPHER JOHN
Inventor： RENNINGER NEIL STEPHEN , NEWMAN JACK , REILING KEITH KINKEAD , REGENTIN RIKA , PADDON CHRISTOPHER JOHN
IPC: C12P7/04
Abstract: The present invention provides methods for a robust production of isoprenoids via one or more biosynthetic pathways. The invention also provides nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods. The invention also provides fermentation methods for high productivity of isoprenoids from genetically modified host cells.
Abstract translation: 本发明提供通过一种或多种生物合成途径强力生产类异戊二烯的方法。 本发明还提供用于实施本发明方法的核酸，酶，表达载体和遗传修饰的宿主细胞。 本发明还提供了从遗传修饰的宿主细胞中产生高生产力的发酵方法。
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公开(公告)号：WO2005070961A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/002333
申请日：2005-01-24
Applicant: XENOPORT, INC. , ZERANGUE, Noa , PADDON, Christopher, J.
Inventor： ZERANGUE, Noa , PADDON, Christopher, J.
IPC: C07K14/705
CPC classification number: C07K14/47 , C07K14/705 , G01N33/6872
Abstract: The invention provides several new transporter proteins, nucleic acids encoding them and methods of using the transporters to screen agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the transporters. The invention also provides methods of treatment involving oral delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of one of the transporter.
Abstract translation: 本发明提供了几种新的转运蛋白，编码它们的核酸以及使用转运蛋白筛选连接或可连接于试剂的试剂，缀合物或缀合物部分以便作为底物通过 转运。 本发明还提供了涉及经口递送试剂的治疗方法，所述试剂单独或作为与缀合物部分连接的结果是转运蛋白之一的底物。
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公开(公告)号：WO2007140339A3
公开(公告)日：2009-01-29
申请号：PCT/US2007069807
申请日：2007-05-25
Applicant: AMYRIS BIOTECHNOLOGIES INC , RENNINGER NEIL STEPHEN , NEWMAN JACK , REILING KEITH KINKEAD , REGENTIN RIKA , PADDON CHRISTOPHER JOHN
Inventor： RENNINGER NEIL STEPHEN , NEWMAN JACK , REILING KEITH KINKEAD , REGENTIN RIKA , PADDON CHRISTOPHER JOHN
Abstract: The present invention provides methods for a robust production of isoprenoids via one or more biosynthetic pathways. The invention also provides nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods. The invention also provides fermentation methods for high productivity of isoprenoids from genetically modified host cells.
Abstract translation: 本发明提供通过一种或多种生物合成途径强力生产类异戊二烯的方法。 本发明还提供用于实施本发明方法的核酸，酶，表达载体和经遗传修饰的宿主细胞。 本发明还提供了从遗传修饰的宿主细胞中产生高生产力的发酵方法。
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公开(公告)号：WO2004033655A3
公开(公告)日：2005-06-23
申请号：PCT/US0332087
申请日：2003-10-08
Applicant: XENOPORT INC , ZERANGUE NOA , PADDON CHRISTOPHER
Inventor： ZERANGUE NOA , PADDON CHRISTOPHER
IPC: C07K14/47 , C12Q1/68 , C07K14/435 , C12N15/00 , C12P21/06
CPC classification number: C07K14/47
Abstract: The invention provides several new transporter proteins, nucleic acids encoding them and methods of using the transporters to screen agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the transporters. The invention also provides methods of treatment involving oral delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of one of the transporter.
Abstract translation: 本发明提供几种新的转运蛋白，编码它们的核酸和使用转运蛋白筛选与试剂连接或可连接的试剂，缀合物或缀合物部分，以及通过转运蛋白作为底物转运的能力的方法。 本发明还提供涉及口服递送药物的方法，所述药物单独或作为与缀合物部分连接的结果是转运蛋白之一的底物。
