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公开(公告)号：WO2008058233A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/084067
申请日：2007-11-08
Applicant: MAASTRICHT UNIVERSITY , VANDERBILT UNIVERSITY , EMANS, Pieter, J. , SHASTRI, V., Prasad
Inventor： EMANS, Pieter, J. , SHASTRI, V., Prasad
IPC: C12N5/08
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3852 , A61L2430/06
Abstract: The present invention relates to an in vivo method of promoting the growth of autologous cartilage and bone tissue, including tissue that can be explanted to other locations in the subject.
Abstract translation: 本发明涉及促进自体软骨和骨组织生长的体内方法，所述方法包括可将组织移植到受试者的其他位置。 p>
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公开(公告)号：WO2007081396A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/026322
申请日：2006-07-06
Applicant: A ENTERPRISES, INC. , ASHMAN, Arthur , SHASTRI, V., Prasad
Inventor： ASHMAN, Arthur , SHASTRI, V., Prasad
IPC: A61C8/00 , A61C13/08 , A61F2/28 , A61K20060101 , A61L27/16 , A61L27/26 , A61L27/36 , A61L27/54 , A61L27/58 , B29C35/08 , C08F222/10 , C08J3/28
CPC classification number: A61K6/083 , A61K6/0052 , A61K6/0055 , A61L27/16 , A61L27/54 , A61L2300/406 , A61L2300/414 , A61L2300/604 , A61L2430/02 , C08F222/1006 , C08L33/08 , C08L33/10
Abstract: The present invention relates to novel initiator systems, methods of use, and cured composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to a crosslinkable prepolymer where crosslinking is initiated by a two part system and a composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture and a delivery system for cross-linking the polymer.
Abstract translation: 本发明涉及用于牙科，矫形和药物递送目的的新型引发剂体系，使用方法和固化组合物。 具体地说，本发明涉及一种交联性预聚物，其中交联是由两部分体系引发的，组合物包含可再吸收的骨替代物和可交联预聚物的混合物。 它还涉及通过交联该混合物形成的组合物和用于交联聚合物的递送系统。
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公开(公告)号：WO2009102375A9
公开(公告)日：2009-10-08
申请号：PCT/US2008084523
申请日：2008-11-24
Applicant: RES DEV FOUNDATION , GUTTERMAN JORDAN , PINO CHRISTOPHER , SHASTRI V PRASAD , UNIV VANDERBILT
Inventor： GUTTERMAN JORDAN , PINO CHRISTOPHER , SHASTRI V PRASAD
IPC: A61K47/28
CPC classification number: A61K9/0014 , A61K31/704 , A61K36/00 , A61K45/06 , A61K51/0491 , A61K2300/00
Abstract: The present invention provides compositions of avicins and avicin mixtures that enhance topical, percutaneous, transmucosal, transepithelial, transendothelial or transdermal transport of agents including diagnostic molecules, therapeutic drugs and cosmetic materials.
Abstract translation: 本发明提供了可增强包括诊断分子，治疗药物和化妆品材料的药剂的局部，经皮，透粘膜，经上皮，经内皮或透皮运输的抗生素和抗生素混合物的组合物。
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公开(公告)号：WO2007081396A3
公开(公告)日：2009-04-16
申请号：PCT/US2006026322
申请日：2006-07-06
Applicant: ENTPR INC A , ASHMAN ARTHUR , SHASTRI V PRASAD
Inventor： ASHMAN ARTHUR , SHASTRI V PRASAD
IPC: C08F2/50 , A61C8/00 , A61C13/08 , A61F2/28 , A61K20060101 , A61L27/16 , A61L27/26 , A61L27/36 , A61L27/54 , A61L27/58 , B29C35/08 , C08F222/10 , C08J3/28
CPC classification number: A61K6/083 , A61K6/0052 , A61K6/0055 , A61L27/16 , A61L27/54 , A61L2300/406 , A61L2300/414 , A61L2300/604 , A61L2430/02 , C08F222/1006 , C08L33/08 , C08L33/10
Abstract: The present invention relates to novel initiator systems, methods of use, and cured composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to a crosslinkable prepolymer where crosslinking is initiated by a two part system and a composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture and a delivery system for cross-linking the polymer.
Abstract translation: 本发明涉及用于牙科，矫形和药物递送目的的新型引发剂体系，使用方法和固化组合物。 具体地说，本发明涉及一种交联性预聚物，其中交联是由两部分体系引发的，组合物包含可再吸收的骨替代物和可交联预聚物的混合物。 它还涉及通过交联该混合物形成的组合物和用于交联聚合物的递送系统。
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公开(公告)号：WO2009102375A2
公开(公告)日：2009-08-20
申请号：PCT/US2008/084523
申请日：2008-11-24
Applicant: RESEARCH DEVELOPMENT FOUNDATION , GUTTERMAN, Jordan , PINO, Christopher , SHASTRI, V., Prasad , VANDERBILT UNIVERSITY
Inventor： GUTTERMAN, Jordan , PINO, Christopher , SHASTRI, V., Prasad
IPC: A61K47/28
CPC classification number: A61K9/0014 , A61K31/704 , A61K36/00 , A61K45/06 , A61K51/0491 , A61K2300/00
Abstract: The present invention provides compositions of avicins and avicin mixtures that enhance topical, percutaneous, transmucosal, transepithelial, transendothelial or transdermal transport of agents including diagnostic molecules, therapeutic drugs and cosmetic materials.
Abstract translation: 本发明提供了增强局部，经皮，经粘膜，跨上皮，经内皮或经皮转运包括诊断分子，治疗药物和化妆品材料的药物的avicins和avicin混合物的组合物。
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6.发明申请FUNCTIONALIZED SOLID LIPID NANOPARTICLES AND METHODS OF MAKING AND USING SAME 审中-公开功能化的固体脂质纳米粒子及其制备和使用方法
公开(公告)号：WO2006044660A3
公开(公告)日：2006-05-26
申请号：PCT/US2005037018
申请日：2005-10-14
Applicant: UNIV VANDERBILT , SHASTRI V PRASAD , SUSSMAN ERIC , JAYAGOPAL ASHWATH
Inventor： SHASTRI V PRASAD , SUSSMAN ERIC , JAYAGOPAL ASHWATH
IPC: A61K51/00
CPC classification number: A61K9/5123 , A61K9/0009 , A61K9/5138 , A61K9/5146 , B82Y5/00 , B82Y10/00
Abstract: In one aspect, the invention relates to functionalized solid lipid nanoparticles comprising a neutral lipid and a first functionalized polymer comprising at least one ionic or ionizable moiety and methods for providing same. In a further aspect, the invention relates to tumor targeting therapeutic systems, multimodal diagnostic therapeutic systems, thermoresponsive payload delivery systems, magnetic-driven targeting systems, therapeutic diagnostic systems, stabilized ink compositions, and cosmetic formulations comprising the solid lipid nanoparticles of the invention. In a further aspect, the invention relates to methods of delivering at least one biologically active agent, pharmaceutically active agent, magnetically active agent, or imaging agent across the blood-brain barrier, across a cellular lipid bilayer and into a cell, and to a subcellualr structure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Abstract translation: 一方面，本发明涉及包含中性脂质和包含至少一个离子或可离子化部分的第一官能化聚合物的官能化固体脂质纳米粒子以及用于提供它们的方法。 另一方面，本发明涉及包含本发明的固体脂质纳米颗粒的肿瘤靶向治疗系统，多模态诊断治疗系统，热响应有效负载递送系统，磁驱动靶向系统，治疗诊断系统，稳定化的墨水组合物和化妆品制剂。 另一方面，本发明涉及将至少一种生物活性剂，药物活性剂，磁力活性剂或显像剂穿过血脑屏障，穿过细胞脂质双分子层并递送入细胞和递送至细胞的方法 亚细胞结构。 该摘要旨在作为用于在特定领域中进行搜索的目的的扫描工具，并且不旨在限制本发明。
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公开(公告)号：WO2013023793A3
公开(公告)日：2013-05-10
申请号：PCT/EP2012003504
申请日：2012-08-17
Applicant: UNIV ALBERT LUDWIGS FREIBURG , SHASTRI V PRASAD , FORGET AURELIEN
Inventor： SHASTRI V PRASAD , FORGET AURELIEN
IPC: C08B37/00 , A23L29/256 , A61K8/73 , A61K31/729 , C08H1/00 , C08L5/12 , C12N5/00
CPC classification number: C08B37/006 , A23L29/256 , A61K8/73 , A61K47/36 , A61L31/125 , A61Q90/00 , C08B37/00 , C08B37/003 , C08B37/0039 , C08B37/0042 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08H1/00 , C08L5/00 , C08L5/12 , C10M107/36 , C12N5/0068 , C12N2533/50 , C12N2533/70
Abstract: The present invention discloses a matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11 % of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid group.
Abstract translation: 本发明公开了一种包含由重复二糖单元组成的改性多糖的基质，其中在至少11％的二糖单元中，一个伯醇基被氧化成羧酸基。
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公开(公告)号：WO2008058233A3
公开(公告)日：2008-07-24
申请号：PCT/US2007084067
申请日：2007-11-08
Applicant: MAASTRICHT UNIVERSITY , UNIV VANDERBILT , EMANS PIETER J , SHASTRI V PRASAD
Inventor： EMANS PIETER J , SHASTRI V PRASAD
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3852 , A61L2430/06
Abstract: The present invention relates to an in vivo method of promoting the growth of autologous cartilage and bone tissue, including tissue that can be explanted to other locations in the subject.
Abstract translation: 本发明涉及促进自体软骨和骨组织生长的体内方法，所述骨组织包括可移植到受试者其他位置的组织。
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公开(公告)号：WO2007081396A9
公开(公告)日：2007-09-07
申请号：PCT/US2006026322
申请日：2006-07-06
Applicant: ENTPR INC A , ASHMAN ARTHUR , SHASTRI V PRASAD
Inventor： ASHMAN ARTHUR , SHASTRI V PRASAD
IPC: A61C8/00 , A61C13/08 , A61F2/28 , A61K20060101 , A61L27/16 , A61L27/26 , A61L27/36 , A61L27/54 , A61L27/58 , B29C35/08 , C08F222/10 , C08J3/28
CPC classification number: A61K6/083 , A61K6/0052 , A61K6/0055 , A61L27/16 , A61L27/54 , A61L2300/406 , A61L2300/414 , A61L2300/604 , A61L2430/02 , C08F222/1006 , C08L33/08 , C08L33/10
Abstract: The present invention relates to novel initiator systems, methods of use, and cured composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to a crosslinkable prepolymer where crosslinking is initiated by a two part system and a composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture and a delivery system for cross-linking the polymer.
Abstract translation: 本发明涉及新型引发剂体系，使用方法以及用于牙科，整形外科和药物递送目的的固化组合物。 具体地说，本发明涉及一种由两部分体系和包含可再吸收骨替代物和可交联预聚物的混合物的组合物引发交联的可交联预聚物。 它还涉及通过交联该混合物和用于交联该聚合物的输送系统而形成的组合物。
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公开(公告)号：WO2009102375A3
公开(公告)日：2010-10-14
申请号：PCT/US2008084523
申请日：2008-11-24
Applicant: RES DEV FOUNDATION , GUTTERMAN JORDAN , PINO CHRISTOPHER , SHASTRI V PRASAD , UNIV VANDERBILT
Inventor： GUTTERMAN JORDAN , PINO CHRISTOPHER , SHASTRI V PRASAD
IPC: A61K47/28
CPC classification number: A61K9/0014 , A61K31/704 , A61K36/00 , A61K45/06 , A61K51/0491 , A61K2300/00
Abstract: The present invention provides compositions of avicins and avicin mixtures that enhance topical, percutaneous, transmucosal, transepithelial, transendothelial or transdermal transport of agents including diagnostic molecules, therapeutic drugs and cosmetic materials.
Abstract translation: 本发明提供了增强局部，经皮，经粘膜，跨上皮，经内皮或经皮转运包括诊断分子，治疗药物和化妆品材料的药物的avicins和avicin混合物的组合物。
