公开(公告)号：WO2013133832A3

公开(公告)日：2014-04-03

申请号：PCT/US2012028221

申请日：2012-03-08

Applicant: DANFOSS TURBOCOR COMPRESSORS B V ,  SUN LIN ,  BRASZ JOOST

Inventor： SUN LIN ,  BRASZ JOOST

IPC: F25B13/00

CPC classification number: F25B30/02 ,  F04D17/122 ,  F04D25/06 ,  F04D27/002 ,  F04D27/004 ,  F04D29/048 ,  F04D29/462 ,  F25B1/053 ,  F25B1/10 ,  F25B13/00 ,  F25B41/046 ,  F25B2600/0253 ,  Y02B30/741

Abstract: A heat pump system includes a refrigerant circuit. First and second heat exchangers are arranged in the refrigerant circuit. A flow reversing device selectively changes a direction of flow in the refrigerant circuit between the first and second heat exchangers. A centrifugal compressor is arranged in the fluid circuit and has first and second impellers arranged in series relative to one another to provide a desired compressor pressure ratio. In one example, the centrifugal compressor mounts the first and second impellers on opposing ends of a shaft. The first and second impellers respectively include first and second stage inlets and outlets. One example desired compressor pressure ratio of at least 10:1 corresponds to a second stage outlet pressure to a first stage inlet pressure. A first diffuser is arranged at the first stage outlet, and the first diffuser is a variable geometry diffuser.

Abstract translation: 热泵系统包括制冷剂回路。 第一和第二热交换器布置在制冷剂回路中。 流动反向装置选择性地改变第一和第二热交换器之间的制冷剂回路中的流动方向。 离心压缩机布置在流体回路中，并且具有相对于彼此串联布置的第一和第二叶轮以提供期望的压缩机压力比。 在一个示例中，离心式压缩机将第一和第二叶轮安装在轴的相对端上。 第一和第二叶轮分别包括第一和第二阶段入口和出口。 至少10:1的所需压缩机压力比的一个示例对应于第二级出口压力到第一级入口压力。 第一扩散器布置在第一级出口处，并且第一扩散器是可变几何扩散器。

公开(公告)号：WO2012060825A1

公开(公告)日：2012-05-10

申请号：PCT/US2010/055201

申请日：2010-11-03

Applicant: DANFOSS TURBOCOR COMPRESSORS B.V. ,  SUN, Lin ,  BRASZ, Joost

Inventor： SUN, Lin ,  BRASZ, Joost

IPC: F01D17/08

CPC classification number: F01D17/08 ,  F01D5/145 ,  F02C3/32 ,  F04D27/0238 ,  F04D29/441 ,  F04D29/5846 ,  F04D29/681 ,  F04D29/684 ,  F05D2250/52 ,  F05D2270/17

Abstract: A centrifugal compressor includes a housing providing in inlet, an impeller, a diffuser and a volute or collector. An electric motor is provided in the housing and is configured to drive at least one impeller via a shaft about an axis. The impeller includes an outlet end aligned with a diffuser and arranged at the throat. A variable fluid injector device is arranged downstream from the outlet end of the impeller in one example. The variable fluid injector device is configured to introduce high pressure fluid downstream from the impeller in response to a compressor regulation command. The injected fluid energizes the low momentum boundary layer, which provides compressor stability. A compressor controller is in communication with the variable fluid injection device to obtain a desired compressor operating condition.

Abstract translation: 离心压缩机包括在入口中设置的壳体，叶轮，扩散器和蜗壳或收集器。 电动机设置在壳体中并且构造成经由轴绕轴线驱动至少一个叶轮。 叶轮包括与扩散器对准并布置在喉部处的出口端。 在一个示例中，可变流体注射器装置布置在叶轮的出口端的下游。 可变流体喷射器装置构造成响应于压缩机调节指令而从叶轮下游引入高压流体。 喷射的流体激励低动量边界层，这提供了压缩机的稳定性。 压缩机控制器与可变流体喷射装置连通以获得期望的压缩机运行状态。

公开(公告)号：WO2009088968A2

公开(公告)日：2009-07-16

申请号：PCT/US2009/000016

申请日：2009-01-05

Applicant: THE GENERAL HOSPITAL CORPORATION ,  GETMANOVA, Elena, V. ,  KOVTUN, Alexander ,  SUN, Lin ,  FRITSCH, Edward ,  SEED, Brian

Inventor： GETMANOVA, Elena, V. ,  KOVTUN, Alexander ,  SUN, Lin ,  FRITSCH, Edward ,  SEED, Brian

IPC: C07K14/435 ,  C12N9/10

CPC classification number: C12N9/1044

Abstract: Disclosed herein are methods and compositions related to engineered fragments of the human transglutaminase-related protein family, described herein as engineered transglutaminase barrel proteins (ETBPs), that have utility as high affinity, high selectivity target-binding proteins offering advantages as antibody equivalents for therapeutic, analytical, manufacturing and research purposes. ETBPs differ from naturally occurring human transglutaminase fragments by the addition, deletion, replacement and/or substitution of the naturally occurring amino acid sequence. ETBPs can be easily expressed in prokaryotic cells and in many cases can be purified by a simple solubilization and precipitation method.

Abstract translation: 本文公开了与人转谷氨酰胺酶相关蛋白家族的工程化片段相关的方法和组合物，其被描述为工程化转谷氨酰胺酶桶蛋白质（ETBP），其具有作为高亲和力，高选择性靶结合蛋白的效用，作为治疗用抗体的抗体等同物 ，分析，制造和研究目的。 通过天然存在的氨基酸序列的添加，缺失，替换和/或取代，ETBPs与天然存在的人转谷氨酰胺酶片段不同。 ETBPs可以容易地在原核细胞中表达，并且在许多情况下可以通过简单的溶解和沉淀方法纯化。

公开(公告)号：WO2013039492A1

公开(公告)日：2013-03-21

申请号：PCT/US2011/051504

申请日：2011-09-14

Applicant: DANFOSS TURBOCOR COMPRESSORS B.V. ,  SUN, Lin ,  ALVARES, Jose ,  RASMUSSEN, Mogens

Inventor： SUN, Lin ,  ALVARES, Jose ,  RASMUSSEN, Mogens

IPC: F25B49/02

CPC classification number: F04D27/002 ,  F04D17/10 ,  F04D27/001 ,  F04D27/0246 ,  F04D29/058 ,  F04D29/462 ,  F04D29/464 ,  F25B1/053

Abstract: A centrifugal refrigerant compressor system includes an impeller connected to a shaft. A diffuser is arranged on a downstream side of the impeller and is configured to regulate refrigerant flow exiting the impeller. A magnetic bearing supports the shaft. A sensing element is configured to produce an output relating to a shaft condition. A controller is configured to receive the output and determine an undesired impeller operating condition based upon the shaft condition. The controller is configured to command the diffuser to a desired state in response to the undesired impeller operating condition.

Abstract translation: 离心制冷剂压缩机系统包括连接到轴的叶轮。 扩散器设置在叶轮的下游侧，并且构造成调节离开叶轮的制冷剂流。 磁轴承支撑轴。 感测元件被配置为产生与轴条件有关的输出。 控制器被配置为接收输出并基于轴条件确定不期望的叶轮操作条件。 控制器被配置为响应于不期望的叶轮操作条件来将扩散器命令到期望的状态。

公开(公告)号：WO2010062159A1

公开(公告)日：2010-06-03

申请号：PCT/MY2009/000176

申请日：2009-10-30

Applicant: UNIVERSITI TEKNOLOGI MARA ,  CANTERPRISE LIMITED ,  BLUNT, John ,  COLE, Tony ,  MUNRO, Murray ,  SUN, Lin ,  WEBER, Jean-Frederic, Rene ,  RAMASAMY, Kalavathy ,  ABU BAKAR, Hamidah ,  ABDUL MAJEED, Abu Bakar Bin

Inventor： BLUNT, John ,  COLE, Tony ,  MUNRO, Murray ,  SUN, Lin ,  WEBER, Jean-Frederic, Rene ,  RAMASAMY, Kalavathy ,  ABU BAKAR, Hamidah ,  ABDUL MAJEED, Abu Bakar Bin

IPC: C07K7/64 ,  A61P35/00 ,  A61K38/12 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K38/00 ,  C07K7/64

Abstract: The invention relates to bioactive compounds derived from an endophytic Aspergillus sp . fungus strain isolated from a Malaysian medicinal plant Garcinia scortechinii and to compositions which contain one or more of these compounds. In particular, the invention relates to compounds according to formula I; or a pharmaceutically acceptable salt, solvate, hydrate or prodrug derivative thereof, as pure stereoisomers, mixture of isomers, in enol form or tautomeric form. These compounds have utility in, for example, anti-cancer treatments.

Abstract translation: 本发明涉及衍生自内生真菌曲霉属的生物活性化合物。 从马来西亚药用植物藤黄属中分离的真菌菌株以及含有一种或多种这些化合物的组合物。 特别地，本发明涉及式I化合物; 或其药学上可接受的盐，溶剂合物，水合物或前药衍生物作为纯立体异构体，异构体的混合物，以烯醇形式或互变异构形式。 这些化合物可用于例如抗癌治疗。

公开(公告)号：WO2009088968A3

公开(公告)日：2009-10-08

申请号：PCT/US2009000016

申请日：2009-01-05

Applicant: GEN HOSPITAL CORP ,  GETMANOVA ELENA V ,  KOVTUN ALEXANDER ,  SUN LIN ,  FRITSCH EDWARD ,  SEED BRIAN

Inventor： GETMANOVA ELENA V ,  KOVTUN ALEXANDER ,  SUN LIN ,  FRITSCH EDWARD ,  SEED BRIAN

IPC: C07K14/435 ,  C12N9/10

CPC classification number: C12N9/1044

Abstract: Disclosed herein are methods and compositions related to engineered fragments of the human transglutaminase-related protein family, described herein as engineered transglutaminase barrel proteins (ETBPs), that have utility as high affinity, high selectivity target-binding proteins offering advantages as antibody equivalents for therapeutic, analytical, manufacturing and research purposes. ETBPs differ from naturally occurring human transglutaminase fragments by the addition, deletion, replacement and/or substitution of the naturally occurring amino acid sequence. ETBPs can be easily expressed in prokaryotic cells and in many cases can be purified by a simple solubilization and precipitation method.

Abstract translation: 本文公开的是涉及到人的转谷氨酰胺酶相关蛋白家族的工程改造的片段的方法和组合物，本文所述经改造的转谷氨酰胺酶桶蛋白（ETBPs），即具有作为高亲和力，高的选择性靶标结合蛋白提供的优点抗体等同物用于治疗 ，分析，制造和研究目的。 ETBP与天然存在的人转谷氨酰胺酶片段的不同之处在于天然存在的氨基酸序列的添加，缺失，置换和/或取代。 ETBPs可以在原核细胞中容易地表达，并且在许多情况下可以通过简单的溶解和沉淀方法纯化。

公开(公告)号：WO2008112484A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/056007

申请日：2008-03-06

Applicant: NATIONAL SEMICONDUCTOR CORPORATION ,  MA, Wei ,  LI, Yunhong ,  SUN, Lin

Inventor： MA, Wei ,  LI, Yunhong ,  SUN, Lin

IPC: H04L5/14

CPC classification number: G10K11/178 ,  H04M1/6008

Abstract: A system and method for processing close talking differential microphone array (CTDMA) signals in which incoming microphone signals are transformed from time domain signals to frequency domain signals having separable magnitude and phase information. Processing of the frequency domain signals is performed using the magnitude information, following which phase information is reintroduced using phase information of one of the original frequency domain signals. As a result, high pass filtering effects of conventional differential signal processing of CTDMA signals are substantially avoided.

Abstract translation: 用于处理紧密通话的差分麦克风阵列（CTDMA）信号的系统和方法，其中输入的麦克风信号从时域信号变换到具有可分离的幅度和相位信息的频域信号。 使用幅度信息来执行频域信号的处理，随后使用原始频域信号之一的相位信息重新引入相位信息。 结果，基本上避免了CTDMA信号的常规差分信号处理的高通滤波效应。

公开(公告)号：WO2013039572A1

公开(公告)日：2013-03-21

申请号：PCT/US2012/036868

申请日：2012-05-08

Applicant: DANFOSS TURBOCOR COMPRESSORS B.V. ,  SUN, Lin ,  BISHOP, Paul D. ,  LIN, Huai Yu ,  ALVARES, Jose ,  VEERASURLA, Ramesh

Inventor： SUN, Lin ,  BISHOP, Paul D. ,  LIN, Huai Yu ,  ALVARES, Jose ,  VEERASURLA, Ramesh

IPC: F25B31/02

CPC classification number: F25B31/006 ,  F25B1/005 ,  F25B31/008 ,  F25B40/02 ,  F25B2400/13

Abstract: An example of the disclosed refrigerant system includes a compressor having a motor that is cooled by motor cooling fluid provided to the motor from the main refrigerant loop by a motor cooling circuit. The example system further includes a sub-cooling circuit to cool the motor cooling fluid.

Abstract translation: 所公开的制冷剂系统的一个实例包括一个压缩机，该压缩机具有通过电动机冷却回路从主制冷剂回路供给电动机的电动机冷却流体冷却的电动机。 该示例系统还包括用于冷却电动机冷却流体的副冷却回路。

公开(公告)号：WO2004101620A2

公开(公告)日：2004-11-25

申请号：PCT/US2004/013726

申请日：2004-05-03

Applicant: COMPOUND THERAPEUTICS, INC. ,  LIPOVSEK, Dasa ,  SUN, Lin ,  KOVTUN, Alexander, V.

Inventor： LIPOVSEK, Dasa ,  SUN, Lin ,  KOVTUN, Alexander, V.

IPC: C07K14/76

CPC classification number: C07K14/765

Abstract: Disclosed herein are libraries of candidate binding proteins derived from a serum albumin scaffold, from which useful binding proteins may be selected that are specific for known and unknown targets. Also disclosed herein are methods for selection of serum albumin scaffold-based candidate binding proteins which possess such desired binding characteristics.

Abstract translation: 本文公开了源自血清白蛋白支架的候选结合蛋白的文库，可从其中选择对已知和未知靶特异的有用结合蛋白。 本文还公开了用于选择具有所需结合特征的基于血清白蛋白支架的候选结合蛋白的方法。

公开(公告)号：WO2013112122A3

公开(公告)日：2014-06-19

申请号：PCT/US2012022159

申请日：2012-01-23

Applicant: DANFOSS TURBOCOR COMPRESSORS B V ,  SUN LIN ,  BRASZ JOOST ,  RASMUSSEN MOGENS

Inventor： SUN LIN ,  BRASZ JOOST ,  RASMUSSEN MOGENS

IPC: F25B1/04

CPC classification number: F04D17/12 ,  F04D27/0261 ,  F04D29/462 ,  F04D29/464 ,  F05D2250/52 ,  F25B1/00 ,  F25B1/053 ,  F25B1/10 ,  F25B2600/0253 ,  Y02B30/741

Abstract: A refrigeration system includes a chiller having a refrigerant loop. A compressor is part of and in fluid communication with the refrigerant loop. The compressor has two stages, one with a variable geometry diffuser and one with a fixed geometry diffuser.

Abstract translation: 制冷系统包括具有制冷剂回路的冷却器。 压缩机是制冷剂回路的一部分并且与制冷剂回路流体连通。 压缩机有两个阶段，一个具有可变几何扩散器，一个具有固定的几何扩散器。