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    A MEASUREMENT OF TOTAL REACTIVE NITROGEN, NOY, TOGETHER WITH NO2, NO, AND O3 VIA CAVITY RING-DOWN SPECTROSCOPY
    2.
    发明申请
    A MEASUREMENT OF TOTAL REACTIVE NITROGEN, NOY, TOGETHER WITH NO2, NO, AND O3 VIA CAVITY RING-DOWN SPECTROSCOPY 审中-公开
    总反应性氮的测量，NOY，NO2，NO和O3通过CAVITY RING-DOWN光谱测定

    公开(公告)号：WO2015199870A1

    公开(公告)日：2015-12-30

    申请号：PCT/US2015/032535

    申请日：2015-05-27

    Applicant: THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF COMMERCE

    Inventor： BROWN, Steven, S. ,  DUBE, William, P. ,  WILD, Robert, J.

    IPC: G01N21/31

    CPC classification number: G01N33/0037 ,  G01N33/0016 ,  Y02A50/245

    Abstract: A sensitive, compact detector measures total reactive nitrogen (NOy), as well as NO 2 , NO, and O 3 . In all channels, NO 2 is directly detected by laser diode based cavity ring-down spectroscopy (CRDS) at 405 nm. Ambient O 3 is converted to NO 2 in excess NO for the O 3 measurement channel. Likewise, ambient NO is converted to NO 2 in excess O 3 . Ambient NO y is thermally dissociated at 700C to form NO 2 or NO in a heated quartz inlet. Any NO present in ambient air or formed from thermal dissociation of other reactive nitrogen compounds is converted to NO 2 in excess O 3 after the thermal converter. The precision and accuracy of this instrument make it a versatile alternative to standard chemiluminescence-based NO y instruments.

    Abstract translation: 敏感，紧凑的检测器测量总反应性氮（NOY）以及NO2，NO和O3。 在所有通道中，NO2在405nm处通过基于激光二极管的空穴衰减光谱（CRDS）直接检测。 O3测量通道将环境O3转换为过量NO的NO2。 同样，环境NO转变为过量O 3的NO 2。 环境中的NOy在700℃热解离，在加热的石英入口中形成NO 2或NO。 在热转化器之后，环境空气中存在的任何NO或其他反应性氮化合物的热解离形成的NO转化为过量O 3的NO 2。 该仪器的精度和精度使其成为基于标准化学发光的诺里仪器的通用替代品。

    COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
    用于治疗癌症的组合物和方法

    公开(公告)号：WO2011109422A2

    公开(公告)日：2011-09-09

    申请号：PCT/US2011/026727

    申请日：2011-03-01

    Applicant: THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  KLINMAN, Dennis ,  SHIROTA, Hidekazu

    Inventor： KLINMAN, Dennis ,  SHIROTA, Hidekazu

    IPC: A61K47/48 ,  A61P35/00

    CPC classification number: A61K47/549

    Abstract: Methods for inducing an immune response to a tumor in a subject are disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the CpG ODN is a K-type or a D-type CpG ODN. Methods for treating a tumor in a subject are also disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the tumor cells are autologous. In additional embodiments, the tumor is a lymphoma, cervical cancer, prostate cancer, breast cancer, colon cancer or a lung cancer.

    Abstract translation: 本文公开了诱导受试者对肿瘤的免疫应答的方法。 这些方法包括选择患有肿瘤的受试者并将与CpG寡脱氧核糖核苷酸（ODN）缀合的治疗有效量的凋亡肿瘤细胞给予受试者。 在一些实施方案中，CpG ODN是K型或D型CpG ODN。 本文还公开了治疗受试者中的肿瘤的方法。 这些方法包括选择患有肿瘤的受试者并将与CpG寡脱氧核糖核苷酸（ODN）缀合的治疗有效量的凋亡肿瘤细胞给予受试者。 在一些实施方案中，肿瘤细胞是自体的。 在另外的实施方案中，肿瘤是淋巴瘤，宫颈癌，前列腺癌，乳腺癌，结肠癌或肺癌。

    PROBE AND METHOD FOR OBTAINING THREE-DIMENSIONAL COMPOSITIONAL MAPS OF A BIOLOGICAL SAMPLE
    4.
    发明申请
    PROBE AND METHOD FOR OBTAINING THREE-DIMENSIONAL COMPOSITIONAL MAPS OF A BIOLOGICAL SAMPLE 审中-公开
    用于获得生物样品三维组合物的探针和方法

    公开(公告)号：WO2009032904A1

    公开(公告)日：2009-03-12

    申请号：PCT/US2008/075224

    申请日：2008-09-04

    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  SUBRAMANIAM, Sriram

    Inventor： SUBRAMANIAM, Sriram

    IPC: G01N33/68

    CPC classification number: G01N33/6848 ,  B82Y35/00 ,  G01N33/5082 ,  H01J37/28 ,  H01J37/3053 ,  H01J49/0004 ,  H01J2237/26 ,  H01J2237/28 ,  H01J2237/31745 ,  H01J2237/31749

    Abstract: The invention provides a probe and a method of obtaining a three-dimensional compositional map of one or more targets in a biological sample, or a portion thereof, comprising: (a) milling a surface layer of a biological sample with a focused ion beam, thereby creating a newly exposed surface layer of the biological sample; (b) imaging the newly exposed surface layer of the biological sample; (c) identifying the chemical composition of the newly exposed surface layer of the biological sample, or a portion thereof, with a mass spectrometer; and (d) repeating (a) to (c) until a three-dimensional compositional map of one or more targets in the biological sample, or portion thereof, is obtained. Uses of the three-dimensional map obtained from the inventive method are further provided.

    Abstract translation: 本发明提供一种探针和一种获得生物样品或其一部分中的一种或多种靶的三维组成图的方法，其包括：（a）用聚焦离子束研磨生物样品的表面层， 从而产生生物样品的新暴露的表面层; （b）对生物样品的新暴露的表面层进行成像; （c）用质谱仪鉴定生物样品的新暴露表面层或其一部分的化学成分; 和（d）重复（a）至（c），直到得到生物样品中的一种或多种目标或其部分的三维组成图。 还提供了从本发明方法获得的三维图的使用。

    RIBOSOMAL PROTEIN S3: A FUNCTIONAL COMPONENT OF NF-KAPPA B p65 BINDING COMPLEXES
    7.
    发明申请
    RIBOSOMAL PROTEIN S3: A FUNCTIONAL COMPONENT OF NF-KAPPA B p65 BINDING COMPLEXES 审中-公开
    RIBOSOMAL蛋白S3：NF-KAPPA B p65结合复合物的功能组分

    公开(公告)号：WO2008131426A1

    公开(公告)日：2008-10-30

    申请号：PCT/US2008/061306

    申请日：2008-04-23

    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  LENARDO, Michael ,  WAN, Fengyi

    Inventor： LENARDO, Michael ,  WAN, Fengyi

    IPC: C12N15/11

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14

    Abstract: The invention provides a method of inhibiting the expression of NF-kB target genes in a mammal comprising administering an effective amount of an inhibitor of ribosomal protein S3 (RPS3) to the mammal. The invention also provides a method of inhibiting the induction of immunoglobulin k light chain gene expression in B cells comprising administering an effective amount of an inhibitor of RPS3 to the B cells. The invention further provides a method of treating an inflammatory disease or disorder in a mammal comprising administering an effective amount of an inhibitor of RPS3 to the mammal.

    Abstract translation: 本发明提供抑制哺乳动物中NF-kB靶基因表达的方法，包括向哺乳动物施用有效量的核糖体蛋白S3（RPS3）抑制剂。 本发明还提供抑制B细胞中免疫球蛋白k轻链基因表达诱导的方法，包括向B细胞施用有效量的RPS3抑制剂。 本发明进一步提供了治疗哺乳动物炎性疾病或病症的方法，包括向哺乳动物施用有效量的RPS3抑制剂。

    SMOOTHENED POLYPEPTIDES AND METHODS OF USE
    9.
    发明申请
    SMOOTHENED POLYPEPTIDES AND METHODS OF USE 审中-公开
    平滑聚合物和使用方法

    公开(公告)号：WO2008070357A2

    公开(公告)日：2008-06-12

    申请号：PCT/US2007/083027

    申请日：2007-10-30

    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  TARASOVA, Nadya ,  DEAN, Michael ,  LOU, Hong

    Inventor： TARASOVA, Nadya ,  DEAN, Michael ,  LOU, Hong

    CPC classification number: C07K14/705

    Abstract: Disclosed is an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a Smoothened (SMO) protein, wherein the portion comprises an amino acid sequence of any of the intracellular loops of the SMO protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment, wherein the functional fragment comprises at least 7 contiguous amino acids of the intracellular loops, and wherein the functional fragment or functional variant inhibits proliferation of a diseased cell, or a fatty acid derivative thereof. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided. Methods of inhibiting proliferation of a diseased cell, treating or preventing cancer, treating a neoplasm or psoriasis, and inhibiting the expression of genes involved in the Hedgehog signaling pathway, thereby inhibiting the Hedgehog signaling pathway, are furthermore provided by the invention.

    Abstract translation: 公开了一种分离或纯化的多肽或肽模拟物，其包含Smoothened（SMO）蛋白的一部分的氨基酸序列，其中该部分包含SMO蛋白的任何细胞内环的氨基酸序列，其功能片段或 该部分或功能性片段的功能性变体，其中所述功能片段包含细胞内环的至少7个连续氨基酸，并且其中所述功能片段或功能变体抑制病变细胞或其脂肪酸衍生物的增殖。 进一步提供相关缀合物，核酸，重组表达载体，宿主细胞和药物组合物。 本发明进一步提供了抑制病变细胞增殖，治疗或预防癌症，治疗肿瘤或银屑病以及抑制Hedgehog信号通路参与基因表达从而抑制Hedgehog信号通路的方法。

    METHOD FOR DETERMINING RISK OF ELDERLY PATIENT UNDER MEDICAL TREATMENT AND RELATED SYSTEMS
    10.
    发明申请
    METHOD FOR DETERMINING RISK OF ELDERLY PATIENT UNDER MEDICAL TREATMENT AND RELATED SYSTEMS 审中-公开
    用于确定医疗治疗和相关系统下老年患者风险的方法

    公开(公告)号：WO2008060287A1

    公开(公告)日：2008-05-22

    申请号：PCT/US2006/044718

    申请日：2006-11-17

    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  ABERNETHY, Darrell, R. ,  MAGER, Donald, E. ,  HILMER, Sarah

    Inventor： ABERNETHY, Darrell, R. ,  MAGER, Donald, E. ,  HILMER, Sarah

    IPC: G06F19/00

    CPC classification number: G06F19/3456 ,  G06F19/00 ,  G06F19/326 ,  G16H50/20

    Abstract: Disclosed are methods for determining risk of a therapeutic treatment regimen and for providing a safe therapeutic treatment regimen comprising calculating a total drug burden index of an elderly patient taking at least one medication, e.g., using the equation: TDB = B AC + B s wherein TDB is the total drug burden index, B AC is a drug burden associated with anticholinergic medications, and Bs is a drug burden associated with sedative medications, wherein B AC and B s are each a sum of the expression, D/(δ + D), for every anticholinergic or sedative medication to which the patient is exposed, wherein D is the daily dose of the medication and δ is the recommended minimum daily dose. The invention also provides related systems and computer readable media.

    Abstract translation: 公开了用于确定治疗性治疗方案的风险和提供安全的治疗方案的方法，其包括计算服用至少一种药物的老年患者的总药物负荷指数，例如使用以下等式：TDB = 其中TDB是总药物负荷指数，B是与抗胆碱能药物相关的药物负荷，Bs是与镇静药物相关的药物负荷 其中每个抗胆碱能药或镇静药物暴露于患者时，其中B和/或B各自为表达D /（d + D）的总和， 其中D是药物的日剂量，d是推荐的最小日剂量。 本发明还提供了相关系统和计算机可读介质。

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