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公开(公告)号：WO2014144355A2
公开(公告)日：2014-09-18
申请号：PCT/US2014028725
申请日：2014-03-14
Applicant: ABBOTT LAB
Inventor： TU BAILIN , ZIEMANN ROBERT N , TIEMAN BRYAN C , HEMKEN PHILIP M , RAMSAY CAROL S , STROBEL CAROLYN J , HAWKSWORTH DAVID J , BIRKENMEYER LARRY G , ZHAO CHENG , BROPHY SUSAN E , DOWELL BARRY L , MUERHOFF ANTHONY S
IPC: C07K16/18
CPC classification number: C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , G01N33/57438 , G01N33/6893 , G01N2333/47 , G01N2800/085 , G01N2800/50
Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.
Abstract translation: 本文公开了使用所述抗体检测样品中的高尔基体蛋白73（GP73）和岩藻糖基化GP73的抗体和方法。
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公开(公告)号：WO2009111599A3
公开(公告)日：2012-02-02
申请号：PCT/US2009036098
申请日：2009-03-05
Applicant: ABBOTT LAB , BIRKENMEYER LARRY G , MUERHOFF ANTHONY S , DESAI SURESH M , DAWSON GEORGE J , DILLE BRUCE J
Inventor： BIRKENMEYER LARRY G , MUERHOFF ANTHONY S , DESAI SURESH M , DAWSON GEORGE J , DILLE BRUCE J
IPC: C07K14/445 , G01N33/569
CPC classification number: C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , G01N2469/20
Abstract: The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSPl) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.
Abstract translation: 本发明涉及由疟原虫种疟原虫和卵白念珠菌的源自裂殖子表面蛋白（MSP1）基因的由其编码的核酸序列和氨基酸序列。 这些基因和蛋白质具有许多有益的诊断和治疗用途。
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3.发明申请
公开(公告)号：WO2016069762A3
公开(公告)日：2016-07-07
申请号：PCT/US2015057845
申请日：2015-10-28
Applicant: ABBOTT LAB
Inventor： PROSTKO JOHN , MUERHOFF ANTHONY S , MAROHNIC CHRIS
IPC: G01N33/576
CPC classification number: G01N33/5767 , G01N2333/186 , G01N2333/914 , G01N2469/20
Abstract: The present disclosure provides methods, kits, and compositions for detecting subject anti-HCV antibodies in a sample using NS3 capture peptides. In certain embodiments, at least two NS3 helicase (NS3h) capture peptides and at least two conjugate peptides (e.g., NS3h conjugate peptides) are employed together, which allows for a broad dynamic range of subject antibody detection in a one-step type assay. In other embodiments, methods are provided of detecting NS3-specific subject antibodies without the use of a reducing agent. In some embodiments, NS3-specific subject antibodies are detected with a 'double shot' of NS3 conjugate peptide (e.g., conjugate peptide added to a sample both before and after washing).
Abstract translation: 本公开提供了使用NS3捕获肽检测样品中的受试者抗HCV抗体的方法，试剂盒和组合物。 在某些实施方案中，一起使用至少两种NS3解旋酶（NS3h）捕获肽和至少两种缀合肽（例如NS3h缀合肽），其允许在一步式测定中的主题抗体检测的宽动态范围。 在其它实施方案中，提供了在不使用还原剂的情况下检测NS3特异性目标抗体的方法。 在一些实施方案中，NS3特异性目标抗体用NS3缀合肽“双重”检测（例如，在洗涤前后添加到样品中的结合肽）。
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公开(公告)号：WO9708531A3
公开(公告)日：1997-04-17
申请号：PCT/US9613171
申请日：1996-08-14
Applicant: ABBOTT LAB
Inventor： MUERHOFF ANTHONY S , SIMONS JOHN N , BIRKENMEYER LARRY , LEARY THOMAS P , ERKER JAMES C , DESAI SURESH M , MUSHAHWAR ISA K , CHALMERS MICHELLE , DAWSON GEORGE J
IPC: G01N33/566 , C07K14/18 , C12N15/09 , C12N15/113 , C12N15/86 , C12Q1/70 , G01N33/576 , G01N
CPC classification number: C12N15/1131 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2310/315 , C12N2310/3181 , C12N2310/33 , C12N2770/24222 , C12N2840/203 , C12Q1/6813 , C12Q1/707
Abstract: The invention relates to hepatitis GB virus C. nucleic acids, more particularly to oligonucleotide probes and primers for use in the detection of genotypes of hepatitis GB virus C.
