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公开(公告)号：WO2022035692A1
公开(公告)日：2022-02-17
申请号：PCT/US2021/044909
申请日：2021-08-06
Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
Inventor： KHLEIF, Samir N. , MKRTICHYAN, Mikayel , LEBEDYEVA, Iryna , ALBERS, Thomas
IPC: A61K31/4709 , C07D401/14 , A61K31/4985
Abstract: Compounds and compositions for selectively modulating Akt3 are provided. Methods of using the compounds are also provided. Because Akt3 modulates the suppressive function of natural Tregs and the polarization of induced Tregs, the disclosed compounds are useful for modulating immune responses.
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公开(公告)号：WO2021236891A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/033334
申请日：2021-05-20
Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
Inventor： BROWNING, Darren , LEBEDYEVA, Iryna
IPC: A61K31/519 , C07D231/00 , C07D487/04
Abstract: Provided herein are compounds that inhibit phosphodiesterase 5 (PDE5) and methods of use thereof. Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating gastrointestinal diseases and disorders such as intestinal cancers and inflammatory bowel disease.
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公开(公告)号：WO2022061226A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/051072
申请日：2021-09-20
Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
Inventor： HORUZSKO, Anatoli , LEBEDYEVA, Iryna , ALBERS, Thomas , AJITH, Ashwin
IPC: A61K31/395 , A61K31/4035 , C07D487/02 , C07D487/04 , A61P35/00
Abstract: Provided herein are compounds of formula I or an enantiomer, solvate, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating inflammatory disease, cardiovascular disease, and cancer.
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公开(公告)号：WO2018208647A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/031319
申请日：2018-05-07
Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
Inventor： LEBEDYEVA, Iryna , KLUG, Christopher
IPC: A61K31/221 , C07C279/14
Abstract: Provided are embodiments of creatine and creatine ethyl ester (CEE) salts where the anion is an artificial (non-saccharide) taste-modifier. These compounds represent stable white non-hygroscopic solids or semisolids that can readily dissolve in water and buffer solutions. Synthesis of novel creatine salts using environmentally safe solvents such as ethanol resulted in the formation of products in quantitative yields with sodium or potassium chloride as a byproduct. The creatine and creatine alkyl eater derivative salts are stable sweet-tasting compounds that are more palatable to a consumer than creatine or derivatives thereof.
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公开(公告)号：WO2018100556A1
公开(公告)日：2018-06-07
申请号：PCT/IB2017/057586
申请日：2017-12-01
Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
Inventor： KHLEIF, Samir , MKRTICHYAN, Mikayel , LEBEDYEVA, Iryna
IPC: A61K31/4184 , C07C225/26 , C07C225/34 , C07D235/02
Abstract: Several compounds have been discovered that modulate signal transduction through the PD-1 receptor. In certain embodiments, the compounds promote or induce an activating signal through the PD-1 receptor that activates a T cell. The compounds can bind to PD-1 and inhibit or prevent ligands from binding to PD-1 and thereby suppress inhibitory signal transduction through the PD-1 receptor.
