公开(公告)号：WO2016029200A1

公开(公告)日：2016-02-25

申请号：PCT/US2015/046465

申请日：2015-08-24

Applicant: BRANDEIS UNIVERSITY

Inventor： FRADEN, Seth ,  HEYMANN, Michael ,  LUDWIG, Markus

IPC: B01D9/02 ,  C12M3/00 ,  G01N1/28

CPC classification number: G01N1/28 ,  B01D9/0036 ,  B01D9/0072 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/141 ,  B01L2300/0829 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/161 ,  B01L2300/1894 ,  B01L2400/0487 ,  B01L2400/0688 ,  C12M3/00 ,  G01N23/20025 ,  G01N2001/4016

Abstract: Microfluidic devices and methods for investigating crystallization and/or for controlling a reaction or a phase transition are disclosed. In one embodiment, the microfluidic device includes a reservoir layer; a membrane disposed on the reservoir layer; a wetting control layer disposed on the membrane; and a storage layer disposed on the wetting control layer, wherein the wetting control layer and the storage layer define a microfluidic channel comprising an upstream portion, a downstream portion, a first fluid path in communication with the upstream and the downstream portions, and a storage well positioned within the first fluid path, wherein the wetting control layer includes a fluid passageway in communication with the storage well and the membrane, and wherein the wetting control layer wets a first fluid introduced into the microfluidic channel, the first fluid comprising a hydrophilic, lipophilic, fluorophilic or gas phase as the continuous phase in the microfluidic channel.

Abstract translation: 公开了用于研究结晶和/或控制反应或相变的微流体装置和方法。 在一个实施例中，微流体装置包括储存层; 设置在储存层上的膜; 设置在膜上的润湿控制层; 以及设置在所述润湿控制层上的存储层，其中所述润湿控制层和所述储存层限定微流体通道，所述微流体通道包括上游部分，下游部分，与所述上游部分和所述下游部分连通的第一流体路径， 良好地定位在第一流体路径内，其中润湿控制层包括与储存井和膜连通的流体通道，并且其中润湿控制层润湿引入微流体通道的第一流体，第一流体包含亲水的， 亲油，亲氟或气相作为微流体通道中的连续相。