SERPENTINE SPINAL STABILITY DEVICE AND ASSOCIATED METHODS
    1.
    发明申请
    SERPENTINE SPINAL STABILITY DEVICE AND ASSOCIATED METHODS 审中-公开
    SERPENTINE脊柱稳定性装置及相关方法

    公开(公告)号:WO2012177412A2

    公开(公告)日:2012-12-27

    申请号:PCT/US2012/041360

    申请日:2012-06-07

    Abstract: A spinal implant (100) comprising a plurality of contiguous segments (102, 104, 106) that define a segment array, said plurality of contiguous segments extending from a first side of the segment array to a second side of the segment array in an overlapping configuration, said plurality of contiguous segments operable to apply a torque to a degenerate spinal segment in each of three orthogonal axes (x, y, z). At least one mounting connection (130) is configured to connect said spinal implant to a mounting mechanism, said mounting mechanism being configured to attach said spinal implant to said degenerate spinal segment.

    Abstract translation: 脊柱植入物(100),其包括限定段阵列的多个连续段(102,104,106),所述多个连续段从所述段阵列的第一侧延伸到所述段阵列的第二侧,处于重叠 所述多个连续段可操作以将扭矩施加到三个正交轴(x,y,z)中的每一个中的退化脊柱段。 至少一个安装连接件(130)构造成将所述脊柱植入物连接到安装机构,所述安装机构构造成将所述脊柱植入物附接到所述退化脊柱节段。

    CYTOPLASM TO ORGANELLE DELIVERY SYSTEM AND ASSOCIATED METHODS
    2.
    发明申请
    CYTOPLASM TO ORGANELLE DELIVERY SYSTEM AND ASSOCIATED METHODS 审中-公开
    CYTOPLASM到ORGANELLE交付系统和相关方法

    公开(公告)号:WO2013075131A1

    公开(公告)日:2013-05-23

    申请号:PCT/US2012/065930

    申请日:2012-11-19

    CPC classification number: C12N15/8775 C12N13/00 C12N15/89

    Abstract: Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell can include bringing into proximity outside of a cell a lance and a preselected biological material, charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance, and penetrating an outer portion of the cell with the lance and directing and inserting the lance into the cell but outside of the organelle. The method can further include discharging the lance to release at least a portion of the biological material, charging the lance with an opposite polarity and charge sufficient to electrophoretically drive at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.

    Abstract translation: 提供了将生物材料递送到细胞的细胞器中的系统,装置和方法。 在一个方面,例如,将生物材料引入细胞的细胞器的方法可以包括使细胞附着在喷枪和预选的生物材料的外部,用足够的极性和电荷对喷枪进行充电以电连接 预先选择的具有喷枪的尖端部分的生物材料,并且用喷枪穿透细胞的外部部分并且将喷枪引导并插入细胞中,但是在细胞器外部。 该方法还可以包括排出喷枪以释放生物材料的至少一部分,以相反的极性对喷枪进行充电,并充入足以将至少一部分生物材料电泳驱动到细胞器中,并将枪从 细胞。

    LANCE DEVICE AND ASSOCIATED METHODS FOR DELIVERING A BIOLOGICAL MATERIAL INTO A CELL
    3.
    发明申请
    LANCE DEVICE AND ASSOCIATED METHODS FOR DELIVERING A BIOLOGICAL MATERIAL INTO A CELL 审中-公开
    LANCE设备和将生物材料递送到细胞中的相关方法

    公开(公告)号:WO2012162546A2

    公开(公告)日:2012-11-29

    申请号:PCT/US2012/039437

    申请日:2012-05-24

    CPC classification number: C12N15/89 C12M35/00

    Abstract: Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell.

    Abstract translation: 提供了将生物材料递送到电池中的系统,装置和方法。 在一个示例中,提供了用于将生物材料引入细胞并配置用于包括显微镜的纳米注射系统中的喷枪装置。 这种装置可以包括具有尖端区域和轴区域的喷枪,其中喷枪在结构上构造成允许尖端区域沿着尖端区域的细长轴线并沿着显微镜的焦平面进入和移动到细胞中 。 在另一示例中,喷枪可以被配置为允许尖端区域基本上水平地进入和移动到电池中。

    APPARATUSES AND RELATED METHODS FOR DELIVERING BIOLOGICAL MATERIAL INTO A CELL
    4.
    发明申请
    APPARATUSES AND RELATED METHODS FOR DELIVERING BIOLOGICAL MATERIAL INTO A CELL 审中-公开
    用于将生物材料递送到细胞的装置和相关方法

    公开(公告)号:WO2012159058A2

    公开(公告)日:2012-11-22

    申请号:PCT/US2012/038640

    申请日:2012-05-18

    CPC classification number: C12N15/89 A01K2217/05 C12M35/00

    Abstract: Systems, devices, and methods for protecting a biological material during delivery into a biological structure are provided. In one aspect, for example, a device for protecting and delivering a preselected biological material into a biological structure can include a lance operable to maintain a charge capable of associating a biological material thereto and at least one protective region formed on or in the lance, where the protective region protects the biological material during delivery into a biological structure.

    Abstract translation: 提供了在递送到生物结构期间保护生物材料的系统,装置和方法。 在一个方面,例如,用于保护并将预选生物材料输送到生物结构中的装置可以包括可操作以保持能够将生物材料与其缔合的电荷与形成在喷枪上或其中的至少一个保护区域的喷枪, 其中保护区在输送到生物结构期间保护生物材料。

    APPARATUS WITH MULTIPLE HINGEDLY COUPLED LINKS

    公开(公告)号:WO2019241786A1

    公开(公告)日:2019-12-19

    申请号:PCT/US2019/037497

    申请日:2019-06-17

    Abstract: An apparatus can comprise multiple links, the multiple links comprising at least a first link, a second link, a third link, and a base link, each of the multiple links comprising a rigid sheet, the first link being hingedly coupled to the second link via a first joint, the second link being hingedly coupled to the third link via a second joint, the third link being hingedly coupled to the base link via a third joint, the base link being hingedly coupled to the first link via a fourth joint. The multiple links defining at least a portion of a cylinder when the apparatus is in a stowed position, the first joint, second joint, third joint, and fourth joint being aligned parallel to each other and aligned parallel to a longitudinal axis of the cylinder.

    DEPLOYABLE ORIGAMI-INSPIRED BARRIERS
    6.
    发明申请
    DEPLOYABLE ORIGAMI-INSPIRED BARRIERS 审中-公开
    可扩展的ORIGAMI-INPIRED障碍

    公开(公告)号:WO2018048940A1

    公开(公告)日:2018-03-15

    申请号:PCT/US2017/050329

    申请日:2017-09-06

    Abstract: An example barrier can be switchable between an at least partially collapsed state and at least partially expanded state ( e.g. , a deployed state). For example, the barrier can be fonned from a continuous sheet and a plurality of rigid sections ( e.g. , rigid panels) attached or incorporated into the continuous sheet. The barrier can also include a plurality of hinges, such as hinge lines, between the panels that are formed from the continuous sheet. The hinges enable the barrier to be rigid foldable ( e.g. , the hinges can fold and unfold while the rigid sections remain stiff and rigid) between the expanded and collapsed states.

    Abstract translation: 示例屏障可以在至少部分折叠状态和至少部分展开状态(例如,展开状态)之间切换。 例如,屏障可以由连续片材和多个刚性部分(例如刚性板)形成,所述刚性部分连接或结合到连续片材中。 屏障还可以在由连续片材形成的面板之间包括多个铰链,例如铰链线。 铰链使得障碍在扩展状态和折叠状态之间是刚性可折叠的(例如,铰链可以折叠和展开,而刚性部分保持刚性和刚性)。

    DELIVERY OF BIOLOGICAL MATERIALS INTO CELLULAR ORGANELLES
    7.
    发明申请
    DELIVERY OF BIOLOGICAL MATERIALS INTO CELLULAR ORGANELLES 审中-公开
    将生物材料交付给细胞有机物

    公开(公告)号:WO2012149166A1

    公开(公告)日:2012-11-01

    申请号:PCT/US2012/035222

    申请日:2012-04-26

    CPC classification number: C12N15/85 A01K2217/05 C12N13/00 C12N15/89

    Abstract: Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell includes bringing into proximity a lance and a preselected biological material outside of a cell and charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance. The method also includes penetrating an outer portion of the cell with the lance and directing and inserting the lance into an organelle, discharging the lance to release at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.

    Abstract translation: 提供了将生物材料递送到细胞的细胞器中的系统,装置和方法。 在一个方面,例如,将生物材料引入细胞的细胞器中的方法包括将细胞附近的喷枪和预先选择的生物材料接近,并以足以使预选的电极相互关联的极性和电荷来对喷枪进行充电 具有喷枪尖端部分的生物材料。 该方法还包括用喷枪穿透细胞的外部部分并将喷枪引导并插入细胞器中,排出喷枪以将生物材料的至少一部分释放到细胞器中,并将细胞器从细胞中取出。

    DEPLOYABLE JOINT
    8.
    发明申请
    DEPLOYABLE JOINT 审中-公开
    合作伙伴

    公开(公告)号:WO2016100463A1

    公开(公告)日:2016-06-23

    申请号:PCT/US2015/066016

    申请日:2015-12-16

    Abstract: According to an aspect, a device may include a deployable rolling joint having a first deployable joint member, a second deployable joint member, and a plurality of flexures coupled to the first deployable joint member and the second deployable joint member. The deployable rolling joint may move from an undeployed state to a deployed state in which the first deployable joint member forms a convex surface portion and the second deployable joint member forms a convex surface portion. When the deployable rolling joint is in the deployed state, the convex surface portion of the first deployable joint member may roll with respect the convex surface portion of the second deployable joint member, and the plurality of flexures may hold the first deployable joint member and the second deployable joint member together as the first deployable joint member and the second deployable joint member roll across each other.

    Abstract translation: 根据一个方面,一种装置可以包括可展开的滚动接头,其具有第一可展开接头构件,第二可展开接头构件以及耦合到第一可展开接头构件和第二可展开接头构件的多个挠曲件。 可展开的滚动接头可以从未部署状态移动到展开状态,其中第一可展开接头构件形成凸面部分,第二可展开接头构件形成凸面部分。 当可展开的滚动接头处于展开状态时,第一可展开接头构件的凸面部分可相对于第二可展开接头构件的凸面部分而滚动,并且多个挠曲件可保持第一可展开接头构件和 第一可展开接头构件和第二可展开接头构件彼此滚动。

    ROLLING JOINT JAW MECHANISM
    9.
    发明申请
    ROLLING JOINT JAW MECHANISM 审中-公开
    滚动接头机械

    公开(公告)号:WO2016029047A1

    公开(公告)日:2016-02-25

    申请号:PCT/US2015/046157

    申请日:2015-08-20

    Abstract: According to an aspect, a device may include a shaft, a tool portion including a first arm and a second arm, and a split rolling joint including a first curved portion and a second curved portion. The second curved portion may be coupled to the shaft. The first curved portion may include a first split portion and a second split portion. The first split portion may be coupled to the first arm. The second split portion may be coupled to the second arm. At least one of the first split portion and the second split portion may be configured to roll with respect to the second curved portion such that at least one of the first arm and the second arm can move towards or away from each other.

    Abstract translation: 根据一个方面,一种装置可以包括轴,包括第一臂和第二臂的工具部分,以及包括第一弯曲部分和第二弯曲部分的分割滚动接头。 第二弯曲部分可以联接到轴。 第一弯曲部分可以包括第一分割部分和第二分割部分。 第一分割部分可以联接到第一臂。 第二分割部分可以联接到第二臂。 第一分割部分和第二分割部分中的至少一个可以被配置为相对于第二弯曲部分滚动,使得第一臂和第二臂中的至少一个可以朝着彼此或远离彼此移动。

    CROSSED-CYLINDER WRIST MECHANISM WITH TWO DEGREES OF FREEDOM
    10.
    发明申请
    CROSSED-CYLINDER WRIST MECHANISM WITH TWO DEGREES OF FREEDOM 审中-公开
    具有两度自由度的交叉气缸机构

    公开(公告)号:WO2016014694A1

    公开(公告)日:2016-01-28

    申请号:PCT/US2015/041584

    申请日:2015-07-22

    Abstract: According to an aspect, a device may include a first member, a second member, and a wrist mechanism disposed between the first member and the second member. The wrist mechanism may include a first cylinder portion coupled to the first member, and a second cylinder portion coupled to the second member. The first cylinder portion may be rollably engaged with the second cylinder portion such that movement of the first cylinder portion with respect to the second cylinder portion is configured to cause the first member to move in at least two directions with respect to the second member. The second cylinder portion may be positioned with respect to the first cylinder portion such that a longitudinal axis of the second cylinder portion is orthogonal to a longitudinal axis of the first cylinder portion.

    Abstract translation: 根据一方面,一种装置可以包括设置在第一构件和第二构件之间的第一构件,第二构件和手腕机构。 手腕机构可以包括联接到第一构件的第一气缸部分和联接到第二构件的第二气缸部分。 第一气缸部分可以与第二气缸部分可滚动地接合,使得第一气缸部分相对于第二气缸部分的运动被构造成使得第一部件相对于第二部件在至少两个方向上移动。 第二气缸部分可以相对于第一气缸部分定位,使得第二气缸部分的纵向轴线与第一气缸部分的纵向轴线正交。

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