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公开(公告)号：WO0191773A3
公开(公告)日：2002-05-02
申请号：PCT/US0117386
申请日：2001-05-30
Applicant: ENCELLE INC , USALA ANTON LEWIS
Inventor： USALA ANTON-LEWIS
IPC: A61K8/04 , A61K8/65 , A61K8/73 , A61K38/01 , A61K38/39 , A61L26/00 , A61L27/52 , A61P17/02 , A61P17/14 , A61P43/00 , A61Q7/00 , A61K35/12 , A61K7/06 , A61K35/74
CPC classification number: A61K8/042 , A61K8/65 , A61K8/73 , A61K38/014 , A61K38/39 , A61L26/0052 , A61L26/008 , A61L27/52 , A61L2430/18 , A61Q7/00 , A61K2300/00 , C08L89/06
Abstract: The invention provides a method of stimulating hair growth, comprising administering a therapeutic amount of a hydrogel matrix to an intradermal or subdermal site where hair growth is desired, the matrix composition comprising gelatin, such as denatured collagen, and a long chain carbohydrate, such as dextran. The matrix may further include polar amino acids, nitric oxide inhibitors and super oxide inhibitors. Injection is a preferred method of administration.
Abstract translation: 本发明提供一种刺激毛发生长的方法，包括将治疗量的水凝胶基质施用于需要毛发生长的皮内或皮下部位，所述基质组合物包含明胶，例如变性胶原和长链碳水化合物，例如 右旋糖酐。 基质还可以包括极性氨基酸，一氧化氮抑制剂和超氧化物抑制剂。 注射剂是优选的给药方法。
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Patent Agency Ranking
公开(公告)号：WO0191774A3
公开(公告)日：2002-05-02
申请号：PCT/US0117387
申请日：2001-05-30
Applicant: ENCELLE INC , USALA ANTON LEWIS
Inventor： USALA ANTON-LEWIS
IPC: A61K8/04 , A61K8/65 , A61K8/73 , A61K38/01 , A61K38/39 , A61L26/00 , A61L27/52 , A61P17/02 , A61P17/14 , A61P43/00 , A61Q7/00 , A61K35/12 , A61K35/74
CPC classification number: A61K8/042 , A61K8/65 , A61K8/73 , A61K38/014 , A61K38/39 , A61L26/0052 , A61L26/008 , A61L27/52 , A61L2430/18 , A61Q7/00 , A61K2300/00 , C08L89/06
Abstract: The invention provides a method of treating a chronic ulcer, such as a diabetic ulcer, comprising administering a therapeutic amount of a hydrogen matrix to the ulcer, the matrix composition comprising gelatin and a long chain carbohydrate. The matrix may further include polar amino acids, nitric oxide inhibitors and super oxide inhibitors. Injection is a preferred method of administration. The matrix may be injected into one or more locations within the ulcer, underneath the ulcer and/or around the periphery of the ulcer.
Abstract translation: 本发明提供了治疗慢性溃疡（例如糖尿病性溃疡）的方法，其包括向溃疡施用治疗量的氢基质，所述基质组合物包含明胶和长链碳水化合物。 基质还可以包括极性氨基酸，一氧化氮抑制剂和超氧化物抑制剂。 注射剂是优选的给药方法。 可以将基质注射到溃疡之内，溃疡下方和/或周围溃疡周围的一个或多个位置。
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公开(公告)号：WO0002999A3
公开(公告)日：2000-04-20
申请号：PCT/US9915464
申请日：1999-07-09
Applicant: ENCELLE INC , USALA ANTON LEWIS , KLANN RICHARD CHRIS
Inventor： USALA ANTON-LEWIS , KLANN RICHARD CHRIS
IPC: C12Q1/02 , A61F2/02 , A61K9/00 , A61K31/721 , A61K35/12 , A61K38/39 , A61K47/18 , A61K47/36 , A61K47/42 , A61L15/32 , A61L15/44 , A61L27/22 , A61L27/26 , A61L27/38 , A61L27/52 , A61L27/54 , A61L31/00 , A61L33/00 , A61P15/02 , C12N5/02 , C12N5/06
CPC classification number: A61K9/0024 , A61F2/022 , A61K47/183 , A61K47/36 , A61K47/42 , A61K2035/122 , A61K2035/128 , A61L15/32 , A61L15/44 , A61L27/222 , A61L27/26 , A61L27/3683 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/114 , A61L2300/204 , A61L2300/214 , A61L2300/236 , A61L2300/41 , A61L2300/434 , A61L2300/45 , A61L2300/62 , A61L2430/40 , C08L89/00
Abstract: A cell culture medium and hydrogel matrix for long term storage and proliferation of cells is provided. The cell culture medium and hydrogel matrix may include an effective amount of polar amino acids, the polar amino acids selected from the group consisting of arginine, lysine, histidine, glutamic acid, and aspartic acid. One embodiment of the cell culture medium comprises about 5 to about 150 mM of polar amino acids. The hydrogel matrix comprises about 3 to about 150 mM of polar amino acids. L-arginine and L-glutamic acid are preferably supplemented in the cell culture medium. L-arginine, L-lysine, and L-glutamic acid are preferably supplemented in the hydrogel matrix. A method of maintaining viability and functioning of a transplant is also provided. The method of maintaining viability of a transplant includes encapsulating the cells in a hydrogel matrix and injecting the encapsulated cells into the host organism. The matrix of the present invention may also be used to promote vascularization in a transplant site prior to injection of cells.
Abstract translation: 提供细胞培养基和水凝胶基质用于细胞的长期储存和增殖。 细胞培养基和水凝胶基质可以包括有效量的极性氨基酸，选自精氨酸，赖氨酸，组氨酸，谷氨酸和天冬氨酸的极性氨基酸。 细胞培养基的一个实施方案包含约5至约150mM的极性氨基酸。 水凝胶基质包含约3至约150mM的极性氨基酸。 优选在细胞培养基中补充L-精氨酸和L-谷氨酸。 L-精氨酸，L-赖氨酸和L-谷氨酸优选在水凝胶基质中补充。 还提供了维持移植的活力和功能的方法。 保持移植活力的方法包括将细胞包封在水凝胶基质中并将包封的细胞注射到宿主生物中。 在注射细胞之前，本发明的基质还可用于促进移植部位的血管形成。
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4.发明申请
公开(公告)号：WO0119962A3
公开(公告)日：2001-10-18
申请号：PCT/US0025372
申请日：2000-09-15
Applicant: ENCELLE INC , USALA ANTON LEWIS , KLANN RICHARD CHRIS
Inventor： USALA ANTON-LEWIS , KLANN RICHARD CHRIS
CPC classification number: C12N5/067 , A01N1/02 , A01N1/0226 , C12N5/0676 , C12N2500/32
Abstract: The present invention provides a method of preserving tissue viability during separation, the method including placing intact tissue in a cell culture medium. The cell culture medium includes at least one nitric oxide inhibitor. The tissue is mechanically separated into a plurality of physiologic tissue units, each unit maintaining physiologic cell-to-cell connections within the unit. The mechanical separation step may comprise cutting the tissue into slices and tearing the slices of tissue into a plurality of tissue units. Thereafter, the tissue units may be embedded in a hydrogel matrix for storage.
Abstract translation: 本发明提供了一种在分离过程中保持组织存活力的方法，所述方法包括将完整组织置于细胞培养基中。 细胞培养基包含至少一种一氧化氮抑制剂。 将组织机械地分离成多个生理组织单元，每个单元保持单元内的生理细胞间细胞连接。 机械分离步骤可以包括将组织切割成切片并将组织切片撕成多个组织单元。 此后，组织单元可以嵌入水凝胶基质中以便储存。
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公开(公告)号：WO9937339A3
公开(公告)日：1999-09-30
申请号：PCT/US9901051
申请日：1999-01-19
Applicant: ENCELLE INC , USALA ANTON LEWIS
Inventor： USALA ANTON-LEWIS
Abstract: Methods and compositions for preventing an immune response in a mammal having an implanted transplant are provided. The compositions comprise non-immunogenic aromatic chains with interspersing aliphatic groups. Such compositions are useful as polymer coatings that protect against immune recognition.
Abstract translation: 提供了用于在具有植入的移植物的哺乳动物中预防免疫应答的方法和组合物。 该组合物包含具有散布脂族基团的非免疫原性芳族链。 这种组合物可用作防止免疫识别的聚合物涂层。
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公开(公告)号：WO9720569A3
公开(公告)日：1997-09-18
申请号：PCT/US9618209
申请日：1996-11-14
Applicant: ENCELLE INC , USALA ANTON-LEWIS
Inventor： USALA ANTON-LEWIS
IPC: A61K9/06 , A01N1/02 , A61F2/00 , A61F2/02 , A61K9/00 , A61K31/00 , A61K35/12 , A61K35/37 , A61K35/39 , A61K38/00 , A61K38/17 , A61K47/16 , A61K47/36 , A61K47/42 , A61L27/00 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/38 , A61P3/00 , A61P3/10 , A61P39/00 , C12N5/00 , C12N5/071 , A61K32/12
CPC classification number: A61K9/0024 , A01N1/02 , A01N1/0231 , A61F2/022 , A61F2310/00365 , A61K35/12 , A61K38/00 , A61K2035/126 , A61L27/222 , A61L27/24 , A61L27/26 , A61L27/38 , C12N5/0012 , C12N5/0676 , C12N5/0677 , C12N2500/05 , C12N2500/32 , C12N2509/00 , C12N2533/30 , C12N2533/54 , C12N2533/70
Abstract: An implantable device for the effective release of therapeutically desirable entities including hormones, wherein a matrix containing a cellular moiety which produces a therapeutically desirable entity is encapsulated with a non-immunogenic polymeric material of poly-para-xylylene or other aromatic based moiety having a membrane portion with a porosity effective to block passage therethrough of immunogenic agents while permitting passage therethrough of nutrients for said cellular moiety and of the entity produced thereby; an improved matrix for the storage, manufacture, functional testing, and viral infection testing of cellular moieties comprising a collagen and aqueous nutrient based hydrogel with additives effective for limiting thermal and pressure trauma; and an improved method for the harvesting of cellular moieties from organ tissue by digesting the tissue in the presence of a nitric oxide inhibitor.
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