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    REDOX AND PHOTOINITIATOR SYSTEMS FOR PRIMING FOR IMPROVED ADHERENCE OF GELS TO SUBSTRATES
    1.
    发明申请
    REDOX AND PHOTOINITIATOR SYSTEMS FOR PRIMING FOR IMPROVED ADHERENCE OF GELS TO SUBSTRATES 审中-公开
    用于改善凝胶粘附到基底的红外和光电子系统

    公开(公告)号：WO1996029370A2

    公开(公告)日：1996-09-26

    申请号：PCT/US1996003834

    申请日：1996-03-22

    Applicant: FOCAL, INC. ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  SAWHNEY, Amarpreet, S. ,  MELANSON, David, A. ,  PATHAK, Chandrashekar, P. ,  HUBBELL, Jeffrey, A. ,  AVILA, Luis, Z. ,  KIERAS, Mark, T.

    Inventor： FOCAL, INC. ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    IPC: C09D04/00

    CPC classification number: C09D4/00 ,  A61B17/00491 ,  A61B17/085 ,  A61B2017/00495 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  A61L2300/00 ,  C08F2/48 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/062 ,  C08F290/14 ,  C08F291/00 ,  C08L2666/02 ,  C09J151/00 ,  Y10S602/904 ,  C08L71/02 ,  C08L33/04 ,  C08F220/00

    Abstract: An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

    Abstract translation: 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施方案中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其他表面，或将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。

    POLYMERIC DELIVERY OF RADIONUCLIDES AND RADIOPHARMACEUTICALS
    4.
    发明申请
    POLYMERIC DELIVERY OF RADIONUCLIDES AND RADIOPHARMACEUTICALS 审中-公开
    聚合物递送放射性核素和放射性物质

    公开(公告)号：WO1997033628A1

    公开(公告)日：1997-09-18

    申请号：PCT/US1997002075

    申请日：1997-02-13

    Applicant: FOCAL, INC.

    Inventor： FOCAL, INC. ,  LEAVITT, Richard, D. ,  AVILA, Luis, Z.

    IPC: A61K51/12

    CPC classification number: A61K51/06 ,  A61K51/0497 ,  A61K51/1213

    Abstract: Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.

    Abstract translation: 本地沉积的聚合物储存库用作固定和局部递送放射性核素或放射性药物的载体。 放射性核素作为无机化合物以其元素形式引入，或通过物理或化学方法连接到较大的分子或掺入聚合物中。 可以使用辅助结构来控制释放速率。 可以使用已经用于局部放射治疗的标准放射性核素，例如碘，铱，镭，铯，钇或其它元素的放射性核素。

    REDUCTION OF ADHESIONS USING CONTROLLED DELIVERY OF ACTIVE OXYGEN INHIBITORS
    6.
    发明申请
    REDUCTION OF ADHESIONS USING CONTROLLED DELIVERY OF ACTIVE OXYGEN INHIBITORS 审中-公开
    通过控制输送活性氧气抑制剂减少粘连

    公开(公告)号：WO1996029987A1

    公开(公告)日：1996-10-03

    申请号：PCT/US1996003813

    申请日：1996-03-20

    Applicant: FOCAL, INC.

    Inventor： FOCAL, INC. ,  BAKER, Keith ,  COURY, Arthur, J.

    IPC: A61K09/00

    CPC classification number: A61K9/0024 ,  A61K38/44 ,  A61K38/446 ,  A61K47/32 ,  Y10S514/944 ,  Y10S514/963

    Abstract: SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable profileration of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (I.P.) bolus and by localized sustained release from a topically applied hydrogel system.

    Abstract translation: SOD和其他活性氧抑制剂直接与局部组织损伤部位的阻隔材料结合使用，以防止或减少粘连的形成和细胞的不希望的分泌。 优选的阻隔材料是提供直接施用于受影响组织的AOI的受控释放的聚合物水凝胶。 实施例证明当通过腹膜内（I.P.）推注和通过局部持续释放从局部施用的水凝胶系统施用时，SOD对大鼠骨盆粘连的影响。

    OPTICAL FIBER DIFFUSER AND METHOD OF MAKING
    7.
    发明申请
    OPTICAL FIBER DIFFUSER AND METHOD OF MAKING 审中-公开
    光纤扩散器及其制造方法

    公开(公告)号：WO1998011462A1

    公开(公告)日：1998-03-19

    申请号：PCT/US1997016392

    申请日：1997-09-16

    Applicant: FOCAL, INC. ,  DUMONT, Michael, G.

    Inventor： FOCAL, INC.

    IPC: G02B06/24

    CPC classification number: G02B6/001 ,  A61B18/24 ,  A61B2017/22051 ,  A61B2018/2261 ,  G02B6/241 ,  G02B6/245

    Abstract: An optical fiber device includes a polymeric optical fiber having a proximal end for coupling to a source of light, and a diffusing region. The polymeric optical fiber includes a core and a cladding around the core. The diffusing region includes a length of the polymeric optical fiber in which the cladding is partially removed to expose the core and in which the exposed core and the remaining cladding have a roughened surface for outwardly diffusing light carried through the polymeric optical fiber. The diffusing region is preferably formed by abrasion, for example by directing a particle jet at the optical fiber while rotating and translating the optical fiber with respect to the particle jet. The particle jet may include microscopic glass beads which roughen the optical fiber core. The density of scattering sites may be varied along the length of the diffusing region to produce a desired light output pattern. The optical fiber device is useful in medical application, including as a component of catheter or endoscopic systems.

    Abstract translation: 光纤装置包括具有用于耦合到光源的近端的聚合光纤和漫射区域。 聚合物光纤包括芯和围绕芯的包层。 扩散区域包括聚合物光纤的长度，其中部分去除包层以露出芯，并且其中暴露的芯和剩余的包层具有粗糙表面，用于向外扩散通过聚合物光纤所携带的光。 扩散区优选地通过磨损形成，例如通过在光纤相对于颗粒射流旋转和平移光纤的同时将粒子射流引导到光纤。 颗粒射流可以包括粗糙化光纤芯的微观玻璃珠。 散射位置的密度可以沿着漫射区域的长度变化以产生期望的光输出图案。 光纤设备在医疗应用中是有用的，包括作为导管或内窥镜系统的组件。

    TARGETED DELIVERY VIA BIODEGRADABLE POLYMERS
    10.
    发明申请
    TARGETED DELIVERY VIA BIODEGRADABLE POLYMERS 审中-公开
    通过生物可降解聚合物进行目标交付

    公开(公告)号：WO1996011671A1

    公开(公告)日：1996-04-25

    申请号：PCT/US1995014103

    申请日：1995-10-11

    Applicant: FOCAL, INC.

    Inventor： FOCAL, INC. ,  ROTH, Laurence, A. ,  HERMAN, Stephen, Jack

    IPC: A61K09/127

    CPC classification number: A61K9/0024 ,  A61K9/127 ,  Y10S514/824 ,  Y10S514/964 ,  Y10S514/965

    Abstract: Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriately sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.

    Abstract translation: 通过将生物活性分子固定在与需要递送的细胞相邻的聚合物材料中，生物活性分子（例如编码蛋白质的核酸分子）的递送可以显着增强，其中生物活性分子被包封在诸如脂质体的载体中，这有助于转移 的生物活性分子进入靶组织。 生物活性分子的靶向也可以通过选择合适尺寸的包封介质来实现，由此介质用于将分子递送到特定靶。 例如，将核酸分子或生物活性蛋白质包封在可生物降解的生物相容性聚合物微粒中，其适当尺寸以渗透，但仍被捕获在肺的毛细血管床和肺泡内，可以用于目标递送到身体的这些区域 通过输注或注射给予患者。

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