公开(公告)号：WO2016007821A2

公开(公告)日：2016-01-14

申请号：PCT/US2015/039881

申请日：2015-07-10

Applicant: GENZYME CORPORATION

Inventor： DHAL, Pradeep ,  BESEV, Magnus

IPC: C08G73/06

CPC classification number: A61K31/787 ,  A61K31/785 ,  C08G12/06 ,  C08G12/26 ,  C08G12/34 ,  C08G73/0206 ,  C08G73/0273 ,  C08G73/028 ,  C08G73/0627 ,  C08G73/0644

Abstract: Main chain polyamines comprise amine and ammonium groups along the polymer backbone. Main chain polyamines can be used as pharmaceutical agents and in pharmaceutical compositions. The main chain polyamines are particularly useful in the treatment or prevention of mucositis and infection, specifically oral mucositis and surgical site infection.

Abstract translation: 主链多胺包括沿着聚合物主链的胺和铵基团。 主链多胺可用作药剂和药物组合物。 主链多胺特别可用于治疗或预防粘膜炎和感染，特别是口腔粘膜炎和手术部位感染。

公开(公告)号：WO2014150873A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/024436

申请日：2014-03-12

Applicant: GENZYME CORPORATION

Inventor： HOLMES-FARLEY, Stephen, Randall ,  DHAL, Pradeep ,  BESEV, Magnus ,  MILLER, Robert, J.

IPC: A61K31/785 ,  A61P13/12 ,  A61P9/10 ,  A61P25/28 ,  A61P27/12

CPC classification number: C08F126/02 ,  A61K31/785

Abstract: Sequestrants of AGE precursors comprise amines separated by 2, 3 or 4 carbons. Sequestrants of AGE precursors can be used as pharmaceutical agents and in pharmaceutical compositions. The sequestrants of AGE precursors are particularly useful binding AGE precursors and dietary dicarbonyls in mammals in the gastrointestinal tract for the treatment of ailments such as diabetic nephropathy, chronic renal disease, atherosclerosis, stroke, cataracts, and Alzheimer's disease.

Abstract translation: AGE前体的螯合剂包括被2,3或4个碳分开的胺。 AGE前体的螯合剂可用作药剂和药物组合物。 AGE前体的多价螯合剂在胃肠道的哺乳动物中特异性地结合AGE前体和膳食二羰基用于治疗疾病如糖尿病性肾病，慢性肾脏病，动脉粥样硬化，中风，白内障和阿尔茨海默病。