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公开(公告)号：WO2022140428A2
公开(公告)日：2022-06-30
申请号：PCT/US2021/064669
申请日：2021-12-21
Applicant: GILEAD SCIENCES, INC.
Inventor： BYUN, Daniel H. , CANALES, Eda Y. , DEBIEN, Laurent P. , JANSA, Petr , LEE, Rick A. , LOYER-DREW, Jennifer A. , PERREAULT, Stephane , PYUN, Hyung-Jung , SAITO, Roland D. , SANGI, Michael S. , SCHRIER, Adam J. , SHATSKIKH, Marina E. , TAYLOR, James G. , TREIBERG, Jennifer A. , VAN VELDHUIZEN, Joshua J. , XU, Lianhong
IPC: C07D519/00 , A61P35/02 , A61K31/437
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：WO2023039464A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/076099
申请日：2022-09-08
Applicant: GILEAD SCIENCES, INC.
Inventor： AMMANN, Stephen , CANALES, Eda Y. , CHANG, Weng K. , KINFE, Henok H. , SCHROEDER, Scott D. , LAZERWITH, Scott E. , MITCHELL, Michael L. , MOAZAMI, Yasamin , SHORE, Daniel G.
IPC: A61P29/00 , C07D519/00 , A61K31/4745
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.
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公开(公告)号：WO2020252151A1
公开(公告)日：2020-12-17
申请号：PCT/US2020/037214
申请日：2020-06-11
Applicant: GILEAD SCIENCES, INC.
Inventor： CANALES, Eda Y. , DESAI, Manoj C. , GORMAN, Eric , LI, Jiayao , SAITO, Roland D. , TAYLOR, James G. , WRIGHT, Nathan E.
IPC: A61P3/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) of generic Formula (I) and methods of use and manufacture thereof.
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公开(公告)号：WO2022140326A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064517
申请日：2021-12-21
Applicant: GILEAD SCIENCES, INC.
Inventor： AMMANN, Stephen E. , CANALES, Eda Y. , CHANG, Weng K. , LAZERWITH, Scott E. , SHORE, Daniel G.
IPC: C07D401/04 , C07D401/14 , C07D413/14 , C07D471/04 , A61P37/00 , A61P17/06 , A61K31/437
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.
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公开(公告)号：WO2022140325A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064516
申请日：2021-12-21
Applicant: GILEAD SCIENCES, INC.
Inventor： AMMANN, Stephen E. , CANALES, Eda Y. , CHANG, Weng K. , LAZERWITH, Scott E. , SHORE, Daniel G.
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/10 , A61P17/06 , A61P37/00 , A61K31/437
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.
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公开(公告)号：WO2022173722A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/015582
申请日：2022-02-08
Applicant: GILEAD SCIENCES, INC.
Inventor： AMMANN, Stephen E. , CANALES, Eda Y. , CHANG, Weng K. , CODELLI, Julian A. , JIANG, Lan , KINFE, Henok H. , LAZERWITH, Scott E. , MITCHELL, Michael L. , SCHROEDER, Scott D. , SHORE, Daniel G.
IPC: C07D495/04 , A61K31/407 , A61P3/10 , A61P19/00 , A61P29/00
Abstract: The present disclosure relates generally to thioeno[3, 2-], pyrrole derivatives pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.
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公开(公告)号：WO2022140390A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064618
申请日：2021-12-21
Applicant: GILEAD SCIENCES, INC.
Inventor： BYUN, Daniel H. , CAI, Zhenhong R. , CANALES, Eda Y. , DEBIEN, Laurent P. , HANSEN, Timothy R. , HUANG, Richard , JANSA, Petr , LEE, Rick A. , LOYER-DREW, Jennifer A. , MCFADDEN, Ryan , MITCHELL, Michael L. , PYUN, Hyung-Jung , SAITO, Roland D. , SANGI, Michael S. , SCHRIER, Adam J. , SHATSKIKH, Marina E. , TAYLOR, James G. , VAN VELDHUIZEN, Joshua J. , XU, Lianhong
IPC: C07D401/14 , C07D471/04 , C07D519/00 , A61P35/02 , A61K31/437
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：WO2021222353A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/029557
申请日：2021-04-28
Applicant: GILEAD SCIENCES, INC.
Inventor： CANALES, Eda Y. , CHANG, Weng K. , DEBIEN, Laurent P. , JANSA, Petr , LOYER-DREW, Jennifer A. , MARTINEZ, Luisruben P. , PERREAULT, Stephane , PHILLIPS, Gary B. , PYUN, Hyung-Jung , SAITO, Roland D. , SANGI, Michael S. , SCHRIER, Adam J. , SHATSKIKH, Marina E. , TAYLOR, James G. , TREIBERG, Jennifer A. , VAN VELDHUIZEN, Joshua J.
IPC: C07D471/18 , C07D471/22 , C07D487/08 , C07D491/22 , C07D498/18 , C07D498/22 , C07D513/18 , A61P3/10 , A61P7/02 , A61P19/02 , A61P35/00
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
