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公开(公告)号：WO2018039531A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048565
申请日：2017-08-25
Applicant: GILEAD SCIENCES, INC.
Inventor： DU, Jinfa , KAPLAN, Joshua A. , KIRSCHBERG, Thorsten A. , KOBAYASHI, Tetsuya , LAZERWITH, Scott E. , LEE, Rick Andrew , MEDLEY, Jonathan William , MITCHELL, Michael L. , MORGANELLI, Philip Anthony , PYUN, Hyung-Jung , SHEVICK, Sophia L. , SQUIRES, Neil H. , WATKINS, William J.
IPC: C07D487/04 , C07D519/00 , A61K31/407 , A61K31/433 , A61K31/4192 , A61K31/4245 , A61K31/4439
Abstract: This application relates to substituted fused pyrrole compounds of formula I, and pharmaceutical compositions comprising them which inhibit HBV replication, and methods of making and using them. Formula (I)
Abstract translation: 本申请涉及式I的取代的稠合吡咯化合物，以及包含它们的抑制HBV复制的药物组合物，以及制备和使用它们的方法。 公式（I）
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公开(公告)号：WO2021247217A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/032293
申请日：2021-05-13
Applicant: GILEAD SCIENCES, INC.
Inventor： BESTVATER, Brian P. , DU, Zhimin , FARAND, Julie , KAPLAN, Joshua A. , TANG, Doris T. , VENKATARAMANI, Chandrasekar , WANG, Peiyuan , YANG, Kin S. , ZAGORSKA, Anna
IPC: A61P9/00 , A61P11/00 , A61P13/12 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/08 , C07D249/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , A61K31/506 , A61K31/4439
Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).
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公开(公告)号：WO2020150136A1
公开(公告)日：2020-07-23
申请号：PCT/US2020/013319
申请日：2020-01-13
Applicant: GILEAD SCIENCES, INC.
Inventor： BLOMGREN, Peter A. , CURRIE, Kevin S. , FRICK, Morin Mae , HORSTMAN, Elizabeth M. , KAPLAN, Joshua A. , KROPF, Jeffrey E. , WATKINS, William J.
IPC: C07D413/14 , A61P1/16 , A61K31/422
Abstract: The present disclosure relates generally to a compound of formula (I) that binds to FXR and acts as agonists of FXR. The disclosure further relates to the use of the compound for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compound.
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公开(公告)号：WO2019226490A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/032925
申请日：2019-05-17
Applicant: GILEAD SCIENCES, INC.
Inventor： FARAND, Julie , KAPLAN, Joshua A. , NOTTE, Gregory , OLEN, Casey Lockwood , SANGI, Michael , SPERANDIO, David
IPC: C07D213/71 , C07D309/08 , C07D231/18 , C07D233/20 , C07D335/02 , C07C311/08 , C07C311/14 , C07C311/21 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/14 , C07D239/26 , C07D257/04 , C07D275/02 , C07D277/36 , C07D279/12 , C07D305/06 , A61P1/16 , C07F9/46 , C07D451/14 , C07D205/04 , C07D493/08 , C07D295/26
Abstract: Provided is a compound of Formula (I), wherein the variable groups are defined herein.
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公开(公告)号：WO2022240879A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/028597
申请日：2022-05-10
Applicant: GILEAD SCIENCES, INC.
Inventor： BESTVATER, Brian P. , KAPLAN, Joshua A. , NEUBIG, Megan E. , YANG, Kin S. , ZAGORSKA, Anna
IPC: C07D231/40 , C07D401/04 , C07D401/14 , A61P1/16 , A61P11/00 , A61P13/12 , A61P29/00 , A61P35/00 , A61K45/00 , A61K31/415 , A61K31/506 , A61K31/232 , A61K31/4155 , A61K31/4436 , A61K31/4439 , A61K31/519 , A61K38/26 , A61K45/06
Abstract: The application relates to pyrazole derivatives of the general Formula (I) that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The compounds are useful for the treatment of diseases and conditions including fibrosis and liver diseases such as non-alcohol steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).
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公开(公告)号：WO2022212194A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/021912
申请日：2022-03-25
Applicant: GILEAD SCIENCES, INC.
Inventor： BACHMAN, James L. , BYUN, Daniel H. , CLARK, Christopher T. , JANSA, Petr , KAPLAN, Joshua A. , KASUN, Zachary A. , LO, Jennifer R. , NEUBIG, Megan E. , STANLEY, Nathaniel H. , STEVENS, Kirk L.
IPC: C07D401/14 , C07D403/04 , C07D403/14 , C07D417/14 , C07D491/20 , C07D498/20 , A61P1/16 , A61P3/00
Abstract: Compounds of formula (I), wherein the variable substituents are defined herein.
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公开(公告)号：WO2017106556A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/067022
申请日：2016-12-15
Applicant: GILEAD SCIENCES, INC.
Inventor： DU, Zhimin , DORNAN, David , GUERRERO, Juan A. , KAPLAN, Joshua A. , KNOX, John E. , NADUTHAMBI, Devan , PHILLIPS, Barton W. , STINSON, Susanna Y. , VENKATARAMANI, Chandrasekar , WANG, Peiyuan , WATKINS, William J.
IPC: C07D401/14 , C07D413/14 , C07D401/10 , C07D401/12 , C07D405/12 , C07D239/42 , C07D413/12 , A61K31/4433 , A61P35/00 , A61P37/00
CPC classification number: C07F9/65583 , A61K9/0053 , A61K31/4433 , A61K31/4439 , A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/675 , A61K45/06 , C07D239/42 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
Abstract: Compounds having the following formula (I) and methods of their use and preparation are disclosed.
Abstract translation: 公开了具有下式（I）的化合物及其用途和制备方法。
