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    SYSTEM AND METHODS FOR ESTIMATION OF BLOOD FLOW USING RESPONSE SURFACE AND REDUCED ORDER MODELING
    3.
    发明申请
    SYSTEM AND METHODS FOR ESTIMATION OF BLOOD FLOW USING RESPONSE SURFACE AND REDUCED ORDER MODELING 审中-公开

    公开(公告)号：WO2020236639A1

    公开(公告)日：2020-11-26

    申请号：PCT/US2020/033239

    申请日：2020-05-15

    Applicant: HEARTFLOW, INC.

    Inventor： SANKARAN, Sethuraman ,  LESAGE, David ,  TAYLOR, Charles ,  XIAO, Nan ,  KIM, Hyun, Jin ,  SPAIN, David ,  SCHAAP, Michiel

    IPC: G16H50/50

    Abstract: Systems and methods are disclosed for blood flow simulation. For example, a method may include performing a plurality of blood flow simulations using a first model of vascular blood flow, each of the plurality of blood flow simulations simulating blood flow in a vasculature of a patient or a geometry based on the vasculature of the patient; based on results of the plurality of blood flow simulations, generating a response surface mapping one or more first parameters of the first model to one or more second parameters of a reduced order model of vascular blood; determining values for the one or more parameters of the reduced order model mapped, by the response surface, from parameter values representing a modified state of the vasculature; and performing simulation using the reduced order model parameterized by the determined values, to determine a blood flow characteristic of the modified state of the vasculature.

    SYSTEMS AND METHODS FOR ESTIMATING HEMODYNAMIC FORCES ACTING ON PLAQUE AND MONITORING RISK
    4.
    发明申请
    SYSTEMS AND METHODS FOR ESTIMATING HEMODYNAMIC FORCES ACTING ON PLAQUE AND MONITORING RISK 审中-公开
    用于评估在肌肉和监测风险上行动的动脉系统和方法

    公开(公告)号：WO2017011555A1

    公开(公告)日：2017-01-19

    申请号：PCT/US2016/042093

    申请日：2016-07-13

    Applicant: HEARTFLOW, INC.

    Inventor： KOO, Bon-kwon ,  CHOI, Gilwoo ,  KIM, Hyun, Jin ,  TAYLOR, Charles, A.

    IPC: G06F19/00 ,  A61B5/026

    CPC classification number: G16H50/50 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/026 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30

    Abstract: Computer-implemented methods are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion; constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters; estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; and outputting the estimated values of hemodynamic forces to an electronic storage medium. Systems and computer readable media for executing these methods are also disclosed.

    Abstract translation: 公开了计算机实现的方法来估计作用于斑块或病变的血液动力学的值。 一种方法包括：接收容易发生斑块进展，破裂或侵蚀的患者脉管系统的至少一部分的一个或多个患者特异性参数; 使用所接收的一个或多个患者特定参数来构建容易发生斑块进展，破裂或侵蚀的患者脉管系统的至少一部分的患者特异性几何模型; 使用患者特异性参数和几何模型，通过测量，推导或获得压力梯度中的一个或多个来估计使用一个或多个处理器的血液动力的值在患者特异性几何模型上的一个或多个点处， 半径梯度; 并将所述估计的血流动力值输出到电子存储介质。 还公开了用于执行这些方法的系统和计算机可读介质。

    SYSTEMS AND METHODS FOR MODELING CHANGES IN PATENT-SPECIFIC BLOOD VESSEL GEOMETRY AND BOUNDARY CONDITIONS
    5.
    发明申请
    SYSTEMS AND METHODS FOR MODELING CHANGES IN PATENT-SPECIFIC BLOOD VESSEL GEOMETRY AND BOUNDARY CONDITIONS 审中-公开
    专利文献血管几何和边界条件下建立变化的系统与方法

    公开(公告)号：WO2015148401A1

    公开(公告)日：2015-10-01

    申请号：PCT/US2015/022062

    申请日：2015-03-23

    Applicant: HEARTFLOW, INC.

    Inventor： TAYLOR, Charles, A. ,  KIM, Hyun, Jin ,  SANKARAN, Sethuraman ,  SCHAAP, Michiel ,  EBERLE, David ,  CHOI, Gilwoo ,  GRADY, Leo, J.

    IPC: G06F19/00

    CPC classification number: G06F19/3437 ,  G06F17/5009 ,  G06F19/00 ,  G16H50/50

    Abstract: Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.

    Abstract translation: 公开了系统和方法，用于模拟患者特异性血管几何形状和由血流或压力变化引起的边界条件的变化。 一种方法包括使用处理器确定患者的一个或多个血管的第一解剖模型; 至少基于所述第一解剖模型确定所述一个或多个血管的生物力学模型; 确定与患者的生理状态相关联的一个或多个参数; 以及基于生物力学模型和与生理状态相关联的一个或多个参数创建第二解剖模型。

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