公开(公告)号：WO2018189210A1

公开(公告)日：2018-10-18

申请号：PCT/EP2018/059213

申请日：2018-04-11

申请人： INSTITUT GUSTAVE ROUSSY

发明人： APCHER, Sébastien ,  PIERSON, Alison ,  BOULPICANTE, Mathilde ,  DOLOR, Renko, Zafiarisoa ,  ALAMI, Mouad ,  DARRIGRAND, Romain

IPC分类号： C07D311/30 ,  A61K31/352 ,  A61P35/00

摘要： The present invention relates to the fields of medicine and cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cancer cells in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a cancer therapy in a subject in need thereof. The invention also discloses methods for preventing or treating cancer, cancer metastasis and/or cancer recurrence in a subject. The present invention in addition provides kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.

公开(公告)号：WO2019207257A1

公开(公告)日：2019-10-31

申请号：PCT/FR2019/050982

申请日：2019-04-26

申请人： UNIVERSITE PARIS-SUD ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT GUSTAVE-ROUSSY ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： ALAMI, Mouad ,  PROVOT, Olivier ,  HAMZE, Abdallah ,  KHELIFI, Ilhem ,  NARET, Timothée ,  APCHER, Sébastien ,  DARRIGRAND, Romain

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/473 ,  A61K31/4725 ,  A61K31/517 ,  A61K31/4709 ,  A61K31/4706 ,  A61P35/00

摘要： La présente invention concerne un composé de formule (I) suivante : ou un sel pharmaceutiquement acceptable de celui-ci. La présente invention concerne également une composition pharmaceutique contenant un tel composé, un procédé de préparation d'un tel composé et son utilisation en tant qu'agent antivasculaire par inhibition de la polymérisation de la tubuline et/ou en tant qu'agent ayant des propriétés immunomodulatrice.

公开(公告)号：WO2020099650A1

公开(公告)日：2020-05-22

申请号：PCT/EP2019/081516

申请日：2019-11-15

申请人： INSTITUT GUSTAVE ROUSSY ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PARIS-SACLAY

发明人： APCHER, Sébastien ,  ALAMI, Mouad ,  DARRIGRAND, Romain ,  MESSAOUDI, Samir ,  SALGUES, Valérie ,  RENKO, Zafiarisoa, Dolor ,  YEN-PON, Expedite

IPC分类号： A61K31/517 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/7064 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07D239/84

摘要： The present invention relates to the fields of medicine and in particular cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cells, in particular cancer cells, or changing the immunopeptidome, in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a therapy in a subject in need thereof. The invention also discloses methods for treating a disease, in particular cancer, for preventing or treating cancer metastasis and/or cancer recurrence, in a subject. The present invention in addition provides kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.

公开(公告)号：WO2019207257A8

公开(公告)日：2019-10-31

申请号：PCT/FR2019/050982

申请日：2019-04-26

申请人： UNIVERSITE PARIS-SUD ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT GUSTAVE-ROUSSY ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： ALAMI, Mouad ,  PROVOT, Olivier ,  HAMZE, Abdallah ,  KHELIFI, Ilhem ,  NARET, Timothée ,  APCHER, Sébastien ,  DARRIGRAND, Romain

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/473 ,  A61K31/4725 ,  A61K31/517 ,  A61K31/4709 ,  A61K31/4706 ,  A61P35/00

摘要： La présente invention concerne un composé de formule (I) suivante : ou un sel pharmaceutiquement acceptable de celui-ci. La présente invention concerne également une composition pharmaceutique contenant un tel composé, un procédé de préparation d'un tel composé et son utilisation en tant qu'agent antivasculaire par inhibition de la polymérisation de la tubuline et/ou en tant qu'agent ayant des propriétés immunomodulatrice.