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公开(公告)号：WO2015073999A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/066008
申请日：2014-11-17
Applicant: INTEGENX INC.
Inventor： OGG, James , EBERHART, David , NIELSEN, William, D. , FRANKLIN, Helen , JOVANOVICH, Stevan, B.
IPC: B01L99/00
CPC classification number: G01N35/00663 , B01L3/502 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/026 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/044 , B01L2300/0627 , B01L2300/0645 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/12 , B01L2300/123 , B01L2300/18 , B01L2300/1827 , B01L2400/0421 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , B01L2400/0644 , B01L2400/0655 , C12Q1/6818 , C12Q1/686 , C12Q1/6888 , G01N2035/00673
Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.
Abstract translation: 本文提供了用于处理样品的仪器和墨盒。 墨盒包括其中流体运动可由隔膜阀调节的流体回路。 在某些墨盒中，提供隔膜的可变形材料接触仪器中的界面，直接致动隔膜，而不需要中间的致动层。 某些盒具有多个流体回路和流体分配通道或气动分配通道，其被配置为将流体或气动压力选择性地输送到任何流体回路。 某些墨盒具有含有载体试剂的隔室。 隔室可以通过热封将附着在盒体上的膜封闭。
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公开(公告)号：WO2015179098A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/028510
申请日：2015-04-30
Applicant: INTEGENX INC.
Inventor： EBERHART, David , NIELSEN, William, D. , FRANKLIN, Helen , JOVANOVICH, Stevan, B. , LEHTO, Dennis , CHEAR, Kaiwan , KING, David , KLEVENBERG, James , PARK, Chungsoo, Charles , SMITH, Corey , WUNDERLE, Philip, Justus
IPC: C12Q1/68
CPC classification number: C12Q1/6806 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0681 , B01L2300/0848 , B01L2300/087 , B01L2300/123 , B01L2400/0406 , B01L2400/0478 , C12Q1/686 , G01N27/44743 , G01N27/44791 , C12Q1/6846 , C12Q2565/629
Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.
Abstract translation: 本文提供了一种流体盒，其具有包括可延展材料的主体和包含结合到主体表面的可变形材料的层，所述可变形材料密封与形成在主体表面中的一个或多个阀体连通的一个或多个流体通道。 可以通过向可变形材料施加足够的压力来关闭阀门，以压缩和关闭体内的流体通道。 还提供了构造成接合盒的盒接口。 还提供了包括盒式接口和使用盒和系统的方法的系统。
