METHODS AND COMPOSITIONS FOR MODULATING MONOCYTE POPULATIONS AND RELATED USES THEREOF
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR MODULATING MONOCYTE POPULATIONS AND RELATED USES THEREOF 审中-公开
    调节单胞菌人口的方法和组合物及其相关用途

    公开(公告)号:WO2017044946A1

    公开(公告)日:2017-03-16

    申请号:PCT/US2016/051308

    申请日:2016-09-12

    Abstract: Method and compositions for modulating specific populations of monocytes or macrophages are disclosed. Methods include, in certain embodiments, modulating expression or activity of Nr4a1 (Nur77). Compositions disclosed herein include agonistic and antagonistic agents that modulate expression or activity of Nur77, and uses thereof. In various embodiments, methods of treating certain disorders and diseases related to aberrant monocyte or macrophage development are provided. In further various embodiments, methods of identifying agents that modulate specific populations of monocytes or macrophages, and agents that modulate Nur77 activity and/or expression are provided.

    Abstract translation: 公开了调节单核细胞或巨噬细胞特异性群体的方法和组合物。 在某些实施方案中,方法包括调节Nr4a1(Nur77)的表达或活性。 本文公开的组合物包括调节Nur77的表达或活性的激动剂和拮抗剂及其用途。 在各种实施方案中,提供了治疗与异常单核细胞或巨噬细胞发育相关的某些疾病和疾病的方法。 在进一步的各种实施方案中,提供了鉴定调节单核细胞或巨噬细胞的特定群体的试剂和调节Nur77活性和/或表达的试剂的方法。

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