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公开(公告)号:WO2018169901A1
公开(公告)日:2018-09-20
申请号:PCT/US2018/022093
申请日:2018-03-13
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor: LU, Timothy, Kuan-ta , NISSIM, Lior , WU, Ming-ru
IPC: C12N15/85 , C12N15/869 , A61K48/00
Abstract: Aspects of the present disclosure provide synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells). These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.