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1.发明申请THERAPEUTIC METHODS AND COMPOSITIONS USING VIRUSES OF THE RECOMBINANT PARAMYXOVIRIDAE FAMILY 审中-公开使用重组参与病毒家族的病毒的治疗方法和组合物公开(公告)号：WO0120989A9
公开(公告)日：2002-10-03
申请号：PCT/US0026116
申请日：2000-09-22
Applicant: MAYO FOUNDATION , RUSSELL JAMES , CATTANEO ROBERTO , PENG KAH-WHYE , SCHNEIDER URS , MURPHY ANTHEA L
Inventor： RUSSELL JAMES , CATTANEO ROBERTO , PENG KAH-WHYE , SCHNEIDER URS , MURPHY ANTHEA L
IPC: C07K14/485 , C07K14/54 , C07K14/65 , C07K16/28 , C07K16/30 , A01N43/04 , A01N53/00 , C12N7/00 , C12N7/02 , C12N15/00 , C12Q1/70
CPC classification number: C07K14/5434 , A61K2039/505 , C07K14/485 , C07K14/65 , C07K16/2896 , C07K16/3007 , C07K2317/622 , C07K2319/00
Abstract: The invention relates to compositions and methods for treating a patient having a tumor in order to reduce tumor size, comprising administering to the patient a replication-competent Paramyxoviridae virus comprising two or more of a) a nucleic acid sequence encoding a heterologous polypeptide, wherein upon administration the heterologous polypeptide is detectable in a biological fluid of the patient, and detection of the heterologous polypeptide is indicative of Paramyxoviridae virus growth in the patient and reduction in tumor size; b) a recombinant F protein, H protein, or M protein of Paramyxoviridae virus that increases fusogenicity of virus with cells; c) a nucleic acid sequence encoding a cytokine; and d) a Paramyxoviridae virus that is specific for cells of the tumor.
Abstract translation: 本发明涉及用于治疗具有肿瘤的患者以减少肿瘤大小的组合物和方法，包括向患者施用包含两个或更多个a）编码异源多肽的核酸序列的可复制的副粘病毒科病毒，其中在 施用异源多肽在患者的生物流体中是可检测的，并且异源多肽的检测指示患者中副粘病毒病毒生长并减少肿瘤大小; b）副细菌病毒的重组F蛋白，H蛋白或M蛋白，其增加病毒与细胞的融合性; c）编码细胞因子的核酸序列; 和d）对于肿瘤细胞特异的副粘病毒科病毒。
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2.发明申请METHODS AND MATERIALS FOR USING TRANSGENIC NON-HUMAN ANIMALS EXPRESSING SODIUM IODIDE SYMPORTER POLYPEPTIDES TO MONITOR PATHOLOGICAL PROCESSES, DISEASE PROGRESSION, OR THERAPEUTIC RESPONSES OVER TIME 审中-公开方法和材料使用转基因非人动物表达碘酸钠症状多聚酶到监测病理过程，疾病进展或治疗反应时间
公开(公告)号：WO2016168683A3
公开(公告)日：2016-11-17
申请号：PCT/US2016027876
申请日：2016-04-15
Applicant: MAYO FOUNDATION
Inventor： PENG KAH-WHYE , RUSSELL STEPHEN JAMES , LECH PATRYCJA , SUKSANPAISAN LUKKANA
CPC classification number: A01K67/0275 , A01K2207/20 , A01K2217/05 , A01K2227/105 , A01K2267/0393
Abstract: This document provides methods and materials for using live transgenic non-human animals (e.g., non-human mammals) to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time. For example, methods and materials for using live transgenic non-human animals (e.g., non-human mammals) having somatic and germline cells that include nucleic acid (e.g., a transgene) having a promoter sequence operably linked to a nucleic acid sequence encoding a NIS polypeptide to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time are provided.
Abstract translation: 本文件提供了使用活的转基因非人类动物（例如，非人类哺乳动物）进行放射性示踪剂成像以随时间在体内监测病理过程，疾病进展或治疗反应的方法和材料。 例如，使用具有体细胞和种系细胞的活的转基因非人动物（例如，非人类哺乳动物）的方法和材料，其包括核酸（例如，转基因），其具有可操作地连接于编码 提供NIS多肽进行放射性示踪剂成像以监测病理过程，疾病进展或体内随时间的治疗反应。
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3.发明申请RADIOTRACER IMAGING USING SODIUM IODIDE SYMPORTER POLYPEPTIDES 审中-公开放射线成像使用碘化钠SYMPORTER POLYPEPTIDES
公开(公告)号：WO2014197069A3
公开(公告)日：2015-03-26
申请号：PCT/US2014026120
申请日：2014-03-13
Applicant: MAYO FOUNDATION
Inventor： RUSSELL STEPHEN JAMES , PENG KAH-WHYE , LECH PATRYCJA
IPC: A61K51/02
CPC classification number: C07K14/4702 , A61K51/00 , A61K51/02 , A61K51/025 , A61K51/12
Abstract: This document provides methods and materials involved in radiotracer imaging using NIS polypeptides. For example, methods and materials for performing imaging techniques that increase the detection sensitivity and resolution of radiotracers localized by NIS reporter gene expression and/or decrease background signals that can be attributed to endogenously expressed NIS polypeptides are provided.
Abstract translation: 本文档提供使用NIS多肽的放射性示踪剂成像中涉及的方法和材料。 例如，提供了用于执行增强通过NIS报道基因表达定位的放射性示踪剂的检测灵敏度和分辨率的成像技术的方法和材料，和/或降低可归因于内源表达的NIS多肽的背景信号。
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公开(公告)号：WO2014197069A2
公开(公告)日：2014-12-11
申请号：PCT/US2014026120
申请日：2014-03-13
Applicant: MAYO FOUNDATION
Inventor： RUSSELL STEPHEN JAMES , PENG KAH-WHYE , LECH PATRYCJA
IPC: A61K51/08
CPC classification number: C07K14/4702 , A61K51/00 , A61K51/02 , A61K51/025 , A61K51/12
Abstract: This document provides methods and materials involved in radiotracer imaging using NIS polypeptides. For example, methods and materials for performing imaging techniques that increase the detection sensitivity and resolution of radiotracers localized by NIS reporter gene expression and/or decrease background signals that can be attributed to endogenously expressed NIS polypeptides are provided.
Abstract translation: 本文件提供使用NIS多肽的放射性示踪剂成像中涉及的方法和材料。 例如，提供了用于执行增强通过NIS报道基因表达定位的放射性示踪剂的检测灵敏度和分辨率的成像技术的方法和材料和/或降低可归因于内源表达的NIS多肽的背景信号。
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公开(公告)号：WO2008008917A2
公开(公告)日：2008-01-17
申请号：PCT/US2007073397
申请日：2007-07-12
Applicant: MAYO FOUNDATION , RUSSELL STEPHEN J , PENG KAH-WHYE , ONG HOOI TIN
Inventor： RUSSELL STEPHEN J , PENG KAH-WHYE , ONG HOOI TIN
CPC classification number: A61K51/0489 , A61F2/28 , A61F2310/00293 , A61K51/1027 , A61K51/1244
Abstract: This document provides methods and materials related to hydroxyapatite particles. For example, hydroxyapatite particles, methods for making hydroxyapatite particles, and methods for using hydroxyapatite particles are provided herein.
Abstract translation: 本文件提供了与羟基磷灰石颗粒相关的方法和材料。 例如，提供羟基磷灰石颗粒，制备羟基磷灰石颗粒的方法，以及使用羟基磷灰石颗粒的方法。
