公开(公告)号：WO2022106361A1

公开(公告)日：2022-05-27

申请号：PCT/EP2021/081705

申请日：2021-11-15

Applicant: MICROCAPS AG

Inventor： BIFFI, Giulia ,  ROZAS, Luis ,  BEN HADJ YOUSSEF, Nesrine ,  DIENER, Michael

IPC: B01J13/04 ,  A61K9/50 ,  B01J13/22 ,  C11D3/50

Abstract: Disclosed is a method for generating capsules with a matrix shell encasing an oil core, the method comprising the steps: Providing in a first chamber a core-forming emulsion of an aqueous dispersed phase in an oil phase, the aqueous dispersed phase comprising water and a dissolved gelation-inducing agent, the emulsion further comprising a first surfactant; Providing in a second chamber a second aqueous solution, the aqueous solution comprising water and a second surfactant; wherein the first chamber and the second chamber are fluidic connected by one or more channels, preferably by micro-channels; Guiding the core-forming emulsion of step a. from the first chamber through the one or more channels into the second chamber to form a dispersion of the core-forming emulsion in the aqueous solution of step; Mixing the formed dispersion with an aqueous shell-forming solution, the aqueous shell-forming solution comprising water and a water soluble matrix-forming agent; wherein the gelation-inducing agent and the matrix-forming agent are configured such that they are capable of undergoing a chemical reaction with each other to form a water insoluble matrix shell; Reacting the gelation-inducing agent and the matrix-forming agent in the formed dispersion to form capsules of a water insoluble matrix shell encasing an oil core.