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公开(公告)号：WO2016025865A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045330
申请日：2015-08-14
Applicant: MICROMIDAS, INC.
Inventor： HUCUL, Dennis, A. , HIRSCH-WEIL, Dimitri, A. , MASUNO, Makoto, Nathanael , BISSELL, John, Albert, II , WOOD, Alex, B. , ARAIZA, Robert, Joseph , HENTON, Daniel, R. , BROWNING, Shawn, M. , SMITH, Ryan, L.
IPC: C07B31/00
CPC classification number: C07D307/36 , C07C2/865 , C07D307/38 , C07D307/44 , C07D307/48
Abstract: Provided herein are methods of producing dialkylfurans, such as 2,5-dimethylfuran, and other alkyl furans, such as 2-methylfuran. For example, 2,5-dimethylfuran may be produced by hydrogenation of (5-methylfuran-2-yl) methanol or 2-(chloromethyl)-5-methylfuran in the presence of a solid supported metal catalyst having an excess of either basic or acidic sites (as determined by chemisorption of CO2 or NH3). The process could further include a urea reagent (TMU, DMPU, TMI) and an alkyl benzene.
Abstract translation: 本文提供了生产二烷基呋喃的方法，例如2,5-二甲基呋喃和其它烷基呋喃，如2-甲基呋喃。 例如，2,5-二甲基呋喃可以通过在（5-甲基呋喃-2-基）甲醇或2-（氯甲基）-5-甲基呋喃的氢化下，在具有过量的碱性或碱性的固体负载型金属催化剂的存在下， 酸性位点（通过化学吸附CO 2或NH 3测定）。 该方法还可以包括尿素试剂（TMU，DMPU，TMI）和烷基苯。
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公开(公告)号：WO2013040514A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/055651
申请日：2012-09-14
Applicant: MICROMIDAS INC. , MICHIGAN MOLECULAR INSTITUTE , MASUNO, Makoto, N. , CANNON, Douglas , BISSELL, John , SMITH, Ryan, L. , FOSTER, Marc , WOOD, Alex, Benjamin , SMITH, Patrick, B. , HUCUL, Dennis A.
Inventor： MASUNO, Makoto, N. , CANNON, Douglas , BISSELL, John , SMITH, Ryan, L. , FOSTER, Marc , WOOD, Alex, Benjamin , SMITH, Patrick, B. , HUCUL, Dennis A.
CPC classification number: C07C51/16 , C07C2/52 , C07C2/862 , C07C2/865 , C07C15/08 , C07C2521/18 , C07C2527/02 , C07C2527/053 , C07C2527/08 , C07C2527/10 , C07C2527/122 , C07C2527/126 , C07C2527/128 , C07C2527/132 , C07C2527/133 , C07C2527/135 , C07C2527/138 , C07C2527/14 , C07C2527/16 , C07C2529/08 , C07C2529/14 , C07C2529/24 , C07C2531/02 , C07C2531/04 , C07C2531/12 , C07C15/06
Abstract: The present disclosure provides methods to produce para -xylene, toluene, and other compounds from renewable sources ( e.g ., cellulose, hemicellulose) and ethylene in the presence of an acid, such as a Lewis acid. For example, cellulose and/or hemicellulose may be converted into 2,5-dimethylfuran (DMF) and 2-methylfuran, which may be converted into para -xylene and toluene, respectively. In particular, para -xylene can then be oxidized to form terephthalic acid.
Abstract translation: 本公开提供了在酸例如路易斯酸存在下从可再生来源（例如纤维素，半纤维素）和乙烯生产对二甲苯，甲苯和其它化合物的方法。 例如，纤维素和/或半纤维素可以转化成2,5-二甲基呋喃（DMF）和2-甲基呋喃，其可以分别转化成对二甲苯和甲苯。 特别地，可以将对二甲苯氧化形成对苯二甲酸。
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公开(公告)号：WO2012075051A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/062474
申请日：2011-11-29
Applicant: MICROMIDAS, INC. , SMITH, Ryan, L. , BISSELL, John , MCGRATH, Casey
Inventor： SMITH, Ryan, L. , BISSELL, John , MCGRATH, Casey
Abstract: The present disclosure relates to isolated bacterial strains producing polyhydroxyalkanoate (PHA), microbial consortia including such strains, and cultures of such strains and microbial consortia. In particular, the present disclosure relates to compositions including such strains, microbial consortia, and cultures and methods of use thereof.
Abstract translation: 本公开涉及产生聚羟基链烷酸酯（PHA）的分离的细菌菌株，包括这些菌株的微生物菌群以及这些菌株和微生物菌群的培养物。 特别地，本公开内容涉及包括这些菌株，微生物菌群以及培养物及其使用方法的组合物。
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公开(公告)号：WO2017049211A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/052315
申请日：2016-09-16
Applicant: MICROMIDAS, INC.
Inventor： HENTON, Daniel, R. , MASUNO, Makoto, Nathanael , SMITH, Ryan, L. , WOOD, Alex, B. , HIRSCH-WEIL, Dimitri, A. , GORALSKI, Christian, T. , ARAIZA, Robert, Joseph
IPC: C07D307/48
CPC classification number: C07D307/54
Abstract: Provided herein are methods of producing halomethylfuroic and acyloxymethylfuroic acid and ester compounds from furfural starting compounds. For example, 5-chloromethyl-2-furoic acid may be produced from 5-chloromethylfurfural, in the presence of various oxidants. Salts of the furoic acids may also be produced.
Abstract translation: 本文提供了从糠醛起始化合物制备卤代甲基呋喃甲酰和酰氧基甲基糠酸和酯化合物的方法。 例如，可以在各种氧化剂的存在下从5-氯甲基糠醛制备5-氯甲基-2-糠酸。 也可以生产糠酸的盐。
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5.发明申请
公开(公告)号：WO2015175528A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030364
申请日：2015-05-12
Applicant: MICROMIDAS, INC.
Inventor： MASUNO, Makoto, Nathanael , HIRSCH-WEIL, Dimitri, A. , SMITH, Ryan, L. , BISSELL II, John, Albert
IPC: C07C209/16 , C07D223/10
CPC classification number: C08G69/08 , C07C29/132 , C07C29/149 , C07C45/29 , C07C45/66 , C07C209/68 , C07C2601/14 , C07D223/10 , C07D307/16 , C07D307/52 , C08G69/04 , C08G69/26 , C08G69/28 , C07C211/12
Abstract: Provided herein are methods of producing compounds, such as cyclohexanone, hexanediamine, hexanediol, hexamethylenediamine, caprolactam and nylon, from 5- (halomethyl)furfural.
Abstract translation: 本文提供从5-（卤代甲基）糠醛生产化合物如环己酮，己二胺，己二醇，六亚甲基二胺，己内酰胺和尼龙的方法。
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6.发明申请SOLID FORMS OF 5-(HALOMETHYL) FURFURAL AND METHODS FOR PREPARING THEREOF 审中-公开5-（HOMOMETHYL）FURFUR的固体形式及其制备方法
公开(公告)号：WO2014159738A2
公开(公告)日：2014-10-02
申请号：PCT/US2014/024940
申请日：2014-03-12
Applicant: MICROMIDAS, INC.
Inventor： BROWNING, Shawn, M. , MASUNO, Makoto, N. , BISSELL, John , NICHOLSON, Benjamin, F. , HIRSCH-WEIL, Dimitri, A. , SMITH, Ryan, L.
IPC: C07D307/18
CPC classification number: C07D307/46 , C07D307/18 , C07D307/48
Abstract: Provided are solid forms of 5-(halomethyl)furfural, including a crystalline form of 5- (chloromethyl)furfural. Provided are also methods for preparing solid forms of 5- (halomethyl)furfural by crystallization using certain solvents.
Abstract translation: 提供5-（卤代甲基）糠醛的固体形式，包括5-（氯甲基）糠醛的结晶形式。 还提供了使用某些溶剂通过结晶制备5-（卤代甲基）糠醛的固体形式的方法。
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公开(公告)号：WO2014066746A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066788
申请日：2013-10-25
Applicant: MICROMIDAS, INC.
Inventor： BROWNING, Shawn, M. , BISSELL, John , SMITH, Ryan, L. , MASUNO, Makoto, N. , NICHOLSON, Benjamin, F. , WOOD, Alex, B.
IPC: C07D307/50
CPC classification number: C07D307/50
Abstract: The present disclosure provides methods to produce 5-(halomethyl)furfural, including 5- (chloromethyl)furfural, by acid-catalyzed conversion of biomass. The methods make use of certain organic solvents with temperature-dependent solubility for 5-(halomethyl)furfural. This allows for temperature-dependent phase separation of the 5-(halomethyl)furfural from the reaction mixture. In certain embodiments, solid 5-(halomethyl)furfural may be obtained. The solid 5-(halomethyl)furfural obtained may be amorphous or crystalline.
Abstract translation: 本公开提供通过酸催化转化生物质来生产5-（卤甲基）糠醛的方法，包括5-（氯甲基）糠醛。 该方法利用某些具有温度依赖性溶解度的有机溶剂对5-（卤甲基）糠醛。 这允许5-（卤甲基）糠醛与反应混合物的温度依赖性相分离。 在某些实施方案中，可以获得固体5-（卤甲基）糠醛。 得到的固体5-（卤甲基）糠醛可以是无定形或结晶的。
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公开(公告)号：WO2013181604A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/043716
申请日：2013-05-31
Applicant: MICROMIDAS, INC.
Inventor： SMITH, Ryan, L. , BISSELL, John , MASUNO, Makoto, N. , CANNON, Douglas , WOOD, Alex, B. , FOSTER, Marc
IPC: C07C67/03 , C07C67/31 , C07C69/533 , C07C69/675 , C07C69/732 , C07C1/24 , C07C11/167 , C07C51/16 , C07C57/15 , C07C29/09
CPC classification number: C07C67/31 , C07C1/24 , C07C29/095 , C07C29/149 , C07C51/16 , C07C67/03 , C07C67/30 , C07C2527/167 , C07C69/675 , C07C69/533 , C07C11/167 , C07C57/15 , C07C69/56 , C07C31/207
Abstract: Provided herein are methods that utilize polyhydroxyalkanoates (PHAs) as a substrate for further conversion to C4 and C5 compounds. Polyhydroxyalkanoates can undergo esterification to yield alkyl hydroxyalkanoates and alkyl alkenoates, which may serve as useful precursors in the production of alkadienes and alkenedioic acids, including for example butadiene and butenedioic acid.
Abstract translation: 本文提供了利用聚羟基链烷酸酯（PHA）作为底物进一步转化成C4和C5化合物的方法。 聚羟基链烷酸酯可以进行酯化以得到烷基羟基链烷酸酯和烷基链烯酸酯，其可用作生产烯二酸和烯二酸的有用前体，包括例如丁二烯和丁烯二酸。
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公开(公告)号：WO2012166822A3
公开(公告)日：2012-12-06
申请号：PCT/US2012/040044
申请日：2012-05-30
Applicant: MICROMIDAS INC. , DAVIS, Ryan , ANDERSON, Dane , CANNON, Doug , MCGRATH, Casey , BISSELL, John , SMITH, Ryan, L. , NIELSEN, Wade , NIEDZWIEDZ, Philip , INOUE, Mamie
Inventor： DAVIS, Ryan , ANDERSON, Dane , CANNON, Doug , MCGRATH, Casey , BISSELL, John , SMITH, Ryan, L. , NIELSEN, Wade , NIEDZWIEDZ, Philip , INOUE, Mamie
IPC: C12P7/62
Abstract: The present disclosure provides methods to produce polyhydroxyalkanoates (PHAs) from water-based feedstock streams, which may be heterogeneous suspensions. The methods allow for handling of heterogeneous suspensions in very large flow rates, allowing for high volume processing, and resulting in more cost-effective and efficient process for PHA production.
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10.发明申请DIAMINE COMPOUNDS, DINITRO COMPOUNDS AND OTHER COMPOUNDS, AND METHODS OF PRODUCING THEREOF AND USES RELATED THEREOF 审中-公开DIAMINE化合物，DINITRO化合物及其它化合物及其生产方法及其相关用途
公开(公告)号：WO2016033348A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047237
申请日：2015-08-27
Applicant: MICROMIDAS, INC.
Inventor： WOOD, Alex, B. , MASUNO, Makoto, Nathanael , SMITH, Ryan, L. , BISSELL, John, Albert, II , ARAIZA, Robert, Joseph , HIRSCH-WEIL, Dimitri, A.
IPC: C07D307/48
CPC classification number: C07C211/51 , C07C205/04 , C07C209/32 , C07C211/09 , C07C211/27 , C07C255/35 , C07C2601/16 , C07D307/14 , C07D307/38 , C07D307/42 , C07D307/52 , C07D307/54 , C08F210/02 , C08G69/04 , C08G69/08 , C08G69/26 , C08G69/28 , C08G73/02
Abstract: Provided herein are (phenylene)dialkanamines, and methods of producing such (phenylene)dialkanamines from various furanyl and benzyl compounds. Such furanyl compounds may include, for example, bis(nitroalkyl)furans, bis(aminoalkyl)furans, and nitroalkyl(furan)acetonitriles. Such compounds may include, for example, bis(nitroalkyl)benzenes. Provided herein are also alkyldiamines, and methods for producing such alkyldiamines from furanyl compounds.
Abstract translation: 本文提供的是（亚苯基）二烷胺，以及从各种呋喃基和苄基化合物制备这种（亚苯基）二卡胺的方法。 这样的呋喃基化合物可以包括例如双（硝基烷基）呋喃，双（氨基烷基）呋喃和硝基烷基（呋喃）乙腈。 这样的化合物可以包括例如双（硝基烷基）苯。 本文还提供烷基二胺，以及从呋喃基化合物制备这种烷基二胺的方法。
