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1.发明申请公开(公告)号：WO0021659A9
公开(公告)日：2000-09-08
申请号：PCT/US9923324
申请日：1999-10-07
Applicant: MOTOROLA INC
Inventor： BURDON JEREMY W , HUANG RONG-FONG , WILCOX DAVID , NACLERIO NICHOLAS J , BRISCOE CYNTHIA ANN GORSUCH , GRODZINSKI PIOTR , YU HUINAN , MARRERO ROBERT , GALLAGHER SEAN ROSS , CHAN YUK-TONG , FOLEY BARBARA MCNEIL , DAI XUNHU
IPC: G01N35/08 , B01J19/00 , B01J19/24 , B01J35/02 , B01L3/00 , B01L7/00 , B28B11/00 , B32B18/00 , B81B1/00 , C12M1/00 , C40B60/14 , F04B19/00 , F28D9/00 , F28F13/00 , G01N30/02 , G01N30/52 , G01N30/60 , G01N35/00 , G01N37/00 , H05K1/02 , H05K1/03 , H05K3/46
CPC classification number: G01N30/6069 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00495 , B01J2219/00783 , B01J2219/00835 , B01J2219/00873 , B01J2219/00966 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0627 , B01L2300/0645 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1822 , B01L2400/0415 , B01L2400/0439 , B32B18/00 , B32B2038/042 , B32B2311/06 , B32B2311/08 , B32B2315/02 , B81B2201/058 , B81C1/00119 , B81C2201/019 , C04B2235/6562 , C04B2237/341 , C04B2237/343 , C04B2237/348 , C04B2237/50 , C04B2237/62 , C04B2237/68 , C04B2237/704 , C40B60/14 , F04B19/006 , F28D9/00 , F28D2021/0029 , F28F13/00 , F28F2260/02 , G01N30/60 , G01N30/6004 , G01N30/6095 , G01N2030/025 , G01N2030/528 , G01N2035/00158 , G01N2035/00237 , H05K1/0272 , H05K1/0306 , H05K3/4611 , H05K3/4629
Abstract: A multilayered microfluidic device having a substantially monolithic structure is formed by sintering together a plurality of green-sheet layers. The substantially monolithic structure has an inlet port for receiving fluid, an outlet port for releasing fluid, and an interconnection between the inlet port and the outlet port. The substantially monolithic structure may also include a variety of components to enable useful interaction with the fluid, such as electrically conductive pathways, heaters, fluid sensors, fluid motion transducers, and optically transmissive portions. The components are preferably fabricated using thick-film or green-sheet technology and are preferably co-fired with and sintered to the green-sheet layers to become integral with the substantially monolithic structure. By using an adhesive to bind the green-sheet layers together, the multilayered microfluidic device may be fabricated without the application of high pressures. Selection of an adhesive with a polymer that decomposes at a higher temperature than the binder present in the green-sheet layers promotes stability of the interfaces during the firing process and promotes void-free sintering within the interfacial regions.
Abstract translation: 具有基本上整体结构的多层微流体装置通过将多个绿色层层烧结在一起形成。 基本上单片结构具有用于接收流体的入口端口，用于释放流体的出口端口以及入口端口和出口端口之间的互连。 基本上单片结构还可以包括各种部件，以使得能够与诸如导电通路，加热器，流体传感器，流体运动换能器和光学透射部分之类的流体有用的相互作用。 这些组分优选使用厚膜或生片技术制造，并且优选与生片层共烧并烧结成与基本上一体的结构一体。 通过使用粘合剂将生片层结合在一起，可以在不施加高压的情况下制造多层微流体装置。 使用聚合物粘合剂的选择在温度高于生物层中存在的粘合剂的温度下分解促进了烧结过程中界面的稳定性，并促进界面区域内的无空隙烧结。
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公开(公告)号：WO03030192A9
公开(公告)日：2004-11-04
申请号：PCT/US0225252
申请日：2002-08-07
Applicant: MOTOROLA INC
Inventor： BURDON JEREMY W , HUANG RONG FONG
IPC: B32B37/04 , C04B35/10 , C04B35/638 , C04B37/00 , H01G4/00
CPC classification number: C04B35/10 , B32B18/00 , B32B37/04 , B32B2309/022 , C04B35/632 , C04B35/63444 , C04B35/638 , C04B35/645 , C04B35/653 , C04B2235/36 , C04B2235/656 , C04B2235/9615 , C04B2237/343 , C04B2237/525 , C04B2237/62
Abstract: An intermediate low-pressure laminated ceramic device is formed from a plurality of layers of unfired ceramic material (20) each including ceramic particles in an organic binder. A polymer interfacial layer (22) having a glass transition temperature such that it flows at a temperature below a temperature required for the unfired ceramic layers to substantially deform, is deposited on one surface of each of the unfired ceramic layers. The unfired ceramic layers are stacked with an interfacial layer positioned between adjacent unfired ceramic layers in the stack. The stack is heated to a temperature greater than the glass transition temperature of the interfacial layers and a pressure is applied to the heated stack below approximately 1200 psi to fixedly bond the plurality of layers in the stack together.
Abstract translation: 中间低压层压陶瓷装置由多层未焙烧陶瓷材料（20）形成，每层包含有机粘合剂中的陶瓷颗粒。 具有玻璃化转变温度的聚合物界面层（22）沉积在每个未煅烧的陶瓷层的一个表面上，该玻璃化转变温度使其在低于未焙烧陶瓷层所需的温度的温度下流动以基本变形。 未焙烧的陶瓷层层叠有位于堆叠中的相邻未烧结陶瓷层之间的界面层。 堆叠被加热到大于界面层的玻璃化转变温度的温度，并且将压力施加到低于约1200psi的加热堆叠，以将堆叠中的多个层固定地结合在一起。
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公开(公告)号：WO0141931A9
公开(公告)日：2002-05-30
申请号：PCT/US0033499
申请日：2000-12-11
Applicant: MOTOROLA INC , BRISCOE CYNTHIA G , BURDON JEREMY W , CHAN TONY , FOLEY BARBARA , GRODZINSKI PIOTR , HAWKINS GEORGE , HUANG RONG FONG , KAHN PETER , MARRERO ROBERT , MCGARRY MARK W , TUGGLE TODD , YU HUINAN
Inventor： BRISCOE CYNTHIA G , BURDON JEREMY W , CHAN TONY , FOLEY BARBARA , GRODZINSKI PIOTR , HAWKINS GEORGE , HUANG RONG-FONG , KAHN PETER , MARRERO ROBERT , MCGARRY MARK W , TUGGLE TODD , YU HUINAN
IPC: G01N31/20 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C40B40/02 , C40B50/06 , C40B60/14 , G01N30/02 , G01N30/52 , G01N30/60 , G01N30/66 , G01N35/00 , G01N37/00
CPC classification number: B01L7/52 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00495 , B01J2219/00783 , B01J2219/00824 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00891 , B01J2219/00916 , B01L3/5025 , B01L3/502707 , B01L3/502723 , B01L3/50273 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/14 , B01L2300/1822 , B01L2300/1827 , B01L2300/1883 , B01L2400/0418 , C40B60/14 , F28F2260/02 , G01N30/6069 , G01N30/6095 , G01N2030/0095 , G01N2030/025 , G01N2030/528 , G01N2035/00158 , G01N2035/00237
Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices. In preferred aspects, the devices are fabricated using ceramic multilayer technology to form devices in which parallel, independently controlled molecular reactions, such as nucleic acid amplification reactions including the polymerase chain reaction (PCR) can be performed. Additionally, the devices can include and comprise micro-gas chromatographs similarly fabricated from ceramics.
Abstract translation: 本发明一般涉及用于进行分析的方法和装置，特别是微流体装置。 在优选方面，使用陶瓷多层技术制造器件，以形成其中可以执行并行独立控制的分子反应（例如包括聚合酶链反应（PCR））的核酸扩增反应的装置。 此外，这些装置可以包括并且包括类似地由陶瓷制成的微气相色谱仪。
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公开(公告)号：WO0247148A3
公开(公告)日：2003-05-15
申请号：PCT/US0143858
申请日：2001-11-19
Applicant: MOTOROLA INC
Inventor： BURDON JEREMY W , MIESEM ROSS A , KORIPELLA CHOWDARY RAMESH
IPC: H01L21/48 , H05K1/03 , H05K3/40 , H01L23/498
CPC classification number: H05K3/4061 , H01L21/486 , H05K1/0306 , H05K2201/09581 , H05K2201/09809 , Y10T29/49083 , Y10T29/49155 , Y10T29/49165
Abstract: A method for forming an electrically isolated via in a multilayer ceramic package and an electrical connection formed within the via are disclosed. The method includes punching a first via (30) in a first layer (10), filling the first via with a cross-linkable paste (40), curing the paste to form an electrical insulator precursor and forming the via in the insulator precursor. The electrical connection formed includes an insulator made from a cross-linked paste supported by a substrate of a multilayer ceramic package and a conductive connection supported by the insulator.
Abstract translation: 公开了一种在多层陶瓷封装中形成电隔离通孔的方法和形成在通孔内的电连接。 该方法包括冲压第一层（10）中的第一通孔（30），用可交联的糊剂（40）填充第一通孔，固化糊料以形成电绝缘体前体并在绝缘体前体中形成通孔。 形成的电连接包括由多层陶瓷封装的衬底支撑的交联膏和由绝缘体支撑的导电连接器制成的绝缘体。
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公开(公告)号：WO0141931A3
公开(公告)日：2002-01-03
申请号：PCT/US0033499
申请日：2000-12-11
Applicant: MOTOROLA INC , BRISCOE CYNTHIA G , BURDON JEREMY W , CHAN TONY , FOLEY BARBARA , GRODZINSKI PIOTR , HAWKINS GEORGE , HUANG RONG FONG , KAHN PETER , MARRERO ROBERT , MCGARRY MARK W , TUGGLE TODD , YU HUINAN
Inventor： BRISCOE CYNTHIA G , BURDON JEREMY W , CHAN TONY , FOLEY BARBARA , GRODZINSKI PIOTR , HAWKINS GEORGE , HUANG RONG-FONG , KAHN PETER , MARRERO ROBERT , MCGARRY MARK W , TUGGLE TODD , YU HUINAN
IPC: G01N31/20 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C40B40/02 , C40B50/06 , C40B60/14 , G01N30/02 , G01N30/52 , G01N30/60 , G01N30/66 , G01N35/00 , G01N37/00
CPC classification number: B01L7/52 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00495 , B01J2219/00783 , B01J2219/00824 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00891 , B01J2219/00916 , B01L3/5025 , B01L3/502707 , B01L3/502723 , B01L3/50273 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/14 , B01L2300/1822 , B01L2300/1827 , B01L2300/1883 , B01L2400/0418 , C40B60/14 , F28F2260/02 , G01N30/6069 , G01N30/6095 , G01N2030/0095 , G01N2030/025 , G01N2030/528 , G01N2035/00158 , G01N2035/00237
Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices. In preferred aspects, the devices are fabricated using ceramic multilayer technology to form devices in which parallel, independently controlled molecular reactions, such as nucleic acid amplification reactions including the polymerase chain reaction (PCR) can be performed. Additionally, the devices can include and comprise micro-gas chromatographs similarly fabricated from ceramics.
Abstract translation: 本发明一般涉及用于进行分析的方法和装置，特别是微流体装置。 在优选的方面中，使用陶瓷多层技术来制造器件以形成其中可以执行平行的，独立控制的分子反应（例如包括聚合酶链式反应（PCR）的核酸扩增反应）的器件。 另外，这些装置可以包括并且包括类似地由陶瓷制造的微气相色谱仪。
