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    TEMPERATURE CONTROLLED SOL-GEL CO-CONDENSATION
    3.
    发明申请
    TEMPERATURE CONTROLLED SOL-GEL CO-CONDENSATION 审中-公开
    温度控制溶胶凝固

    公开(公告)号：WO2012100174A1

    公开(公告)日：2012-07-26

    申请号：PCT/US2012/022048

    申请日：2012-01-20

    Applicant: NOVAN, INC. ,  BAO, Jian ,  STASKO, Nathan

    Inventor： BAO, Jian ,  STASKO, Nathan

    IPC: C08G77/26

    CPC classification number: C08G77/26 ,  C08G77/06

    Abstract: Provided according to some embodiments of the invention are methods of making co-condensed macromolecules that include forming a reaction mixture by combining at least one reactant and at least one reagent at a first temperature at which the at least one reactant is substantially unreactive in the presence of the at least one reagent; raising the temperature of the reaction mixture to a second temperature at which the at least one reactant is reactive in the presence of the at least one reagent, wherein the reaction of the at least one reactant in the presence of the at least one reagent produces co-condensed macromolecules such as co-condensed silica macromolecules.

    Abstract translation: 根据本发明的一些实施方案提供的是制备共缩合大分子的方法，其包括通过在至少一种反应物在存在下基本上不反应的第一温度下组合至少一种反应物和至少一种试剂来形成反应混合物 的所述至少一种试剂; 将所述反应混合物的温度升高至所述至少一种反应物在所述至少一种试剂存在下具有反应性的第二温度，其中所述至少一种反应物在所述至少一种试剂存在下的反应产生共聚物 稠化大分子如共缩合二氧化硅大分子。

    COMPOSITIONS FOR TREATING INFLAMMATION AND METHODS OF TREATING THE SAME
    4.
    发明申请
    COMPOSITIONS FOR TREATING INFLAMMATION AND METHODS OF TREATING THE SAME 审中-公开
    用于治疗炎症的组合物和治疗炎症的方法

    公开(公告)号：WO2017151905A1

    公开(公告)日：2017-09-08

    申请号：PCT/US2017/020426

    申请日：2017-03-02

    Applicant: NOVAN, INC.

    Inventor： STASKO, Nathan ,  DOXEY, Ryan ,  MCHALE, Kimberly ,  HOLLENBACH, Stanley J.

    IPC: A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44

    Abstract: Provided herein are compositions useful for treating inflammation in a subject and methods of decreasing inflammation in the skin, mucosa, and/or eye of a subject comprising applying a pharmaceutical composition that includes an NO-releasing compound to the skin, mucosa, and/or eye of the subject in an amount sufficient to decrease inflammation.

    Abstract translation: 本文提供了可用于治疗受试者中的炎症的组合物和减少受试者的皮肤，粘膜和/或眼中的炎症的方法，所述方法包括将包含NO释放性化合物的药物组合物施用于 对象的皮肤，粘膜和/或眼睛的量足以减少炎症。

    TOPICAL COMPOSITIONS AND METHODS OF USING THE SAME
    6.
    发明申请
    TOPICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：WO2018236806A1

    公开(公告)日：2018-12-27

    申请号：PCT/US2018/038188

    申请日：2018-06-19

    Applicant: NOVAN, INC.

    Inventor： STASKO, Nathan ,  DOXEY, Ryan

    IPC: A61K8/44 ,  A61K8/97 ,  A61Q19/08

    Abstract: The present invention relates generally to compositions and methods of using the same such as, for example, methods of treating the skin of a subject using a composition as described herein. The composition may comprise a diluent, a surfactant, a thickening agent, a humectant, a cooling agent, a chelating agent, optionally a pH adjustment agent, and optionally a preservative. The composition may further comprise L-arginine and/or L-citrulline and/or esters and/or derivatives thereof.

    METHODS OF MANUFACTURING TOPICAL COMPOSITIONS AND APPARATUS FOR SAME
    7.
    发明申请
    METHODS OF MANUFACTURING TOPICAL COMPOSITIONS AND APPARATUS FOR SAME 审中-公开
    制备局部组合物的方法和装置

    公开(公告)号：WO2013006613A1

    公开(公告)日：2013-01-10

    申请号：PCT/US2012/045390

    申请日：2012-07-03

    Applicant: NOVAN, INC. ,  KOUGOULOS, Eleftherios ,  STASKO, Nathan

    Inventor： KOUGOULOS, Eleftherios ,  STASKO, Nathan

    IPC: A61K9/00

    CPC classification number: A61K31/655 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/20 ,  A61K47/34 ,  A61K47/38 ,  B01F7/00008 ,  B01F7/164 ,  B01F15/00012 ,  B01F15/00071 ,  B01F15/02 ,  B01F15/06

    Abstract: Provided according to some embodiments of the invention are methods of manufacturing a pharmaceutical composition. In some embodiments, such methods include homogenizing at a first excipient composition that includes a viscosity agent and at least one solvent to form a first premix composition; separately homogenizing at least one active pharmaceutical ingredient (API) and a second excipient composition to form a second premix composition; and combining the first premix composition and the second premix composition to form the composition. The pre-mixing of constituents may increase the stability of the API and provide uniformity of the dispersion of the constituents throughout the final topical composition.

    Abstract translation: 根据本发明的一些实施方案提供的是制备药物组合物的方法。 在一些实施方案中，这些方法包括在包含粘度剂和至少一种溶剂的第一赋形剂组合物上均化以形成第一预混物组合物; 分别均化至少一种活性药物成分（API）和第二赋形剂组合物以形成第二预混物组合物; 以及组合第一预混组合物和第二预混物组合物以形成组合物。 组分的预混合可以增加API的稳定性并提供组分在整个最终局部组合物中的分散体的均匀性。

    NITRIC OXIDE-RELEASING S-NITROSOTHIOL-MODIFIED SILICA PARTICLES AND METHODS OF MAKING THE SAME
    8.
    发明申请
    NITRIC OXIDE-RELEASING S-NITROSOTHIOL-MODIFIED SILICA PARTICLES AND METHODS OF MAKING THE SAME 审中-公开
    氮氧化物释放S-硝基硅烷改性二氧化硅颗粒及其制备方法

    公开(公告)号：WO2012118819A2

    公开(公告)日：2012-09-07

    申请号：PCT/US2012/026960

    申请日：2012-02-28

    Applicant: NOVAN, INC. ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  SCHOENFISCH, Mark ,  RICCIO, Daniel ,  NUGENT, Julia ,  STASKO, Nathan

    Inventor： SCHOENFISCH, Mark ,  RICCIO, Daniel ,  NUGENT, Julia ,  STASKO, Nathan

    IPC: C09D183/08 ,  C07F7/10

    CPC classification number: A61L2/18 ,  C07F7/0874 ,  C07F7/10 ,  C07F7/1836 ,  C08G77/26 ,  C08G77/28 ,  C08K3/28 ,  C08K3/30 ,  C08K2003/023 ,  Y10T428/2982

    Abstract: Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.

    Abstract translation: 根据本发明的一些实施方案提供了形成共缩合二氧化硅颗粒的方法。 在一些实施方案中，所述方法包括在包含水以形成硫醇官能化的共缩合二氧化硅颗粒的反应溶液中使含硫醇的硅烷和骨架烷氧基硅烷反应，其中硫醇官能化的共缩合二氧化硅颗粒包括聚硅氧烷基质和 至少一些硫醇基团存在于聚硅氧烷基质内; 并使硫醇官能化的共缩合二氧化硅颗粒与亚硝化剂反应以提供S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。 在一些实施方案中，提供了S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。

    TOPICAL COMPOSITIONS AND METHODS OF USING THE SAME
    9.
    发明申请
    TOPICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：WO2018236803A1

    公开(公告)日：2018-12-27

    申请号：PCT/US2018/038185

    申请日：2018-06-19

    Applicant: NOVAN, INC.

    Inventor： STASKO, Nathan ,  DOXEY, Ryan

    IPC: A61K8/44 ,  A61K8/97 ,  A61Q19/08

    Abstract: The present invention relates generally to compositions and methods of using the same such as, for example, methods of treating the skin of a subject using a composition as described herein. The composition may comprise a diluent, a solvent, a penetration enhancing agent, a skin brightening agent, a skin renewing agent, a thickening agent, an anti-irritant, a chelating agent, an active pharmaceutical ingredient (API), optionally a pH adjustment agent, and optionally a preservative. The composition may further comprise L-arginine and/or L-citrulline and/or esters and/or derivatives thereof.

    COMPOSITIONS, SYSTEMS, KITS, AND METHODS FOR TREATING AN INFECTION
    10.
    发明申请
    COMPOSITIONS, SYSTEMS, KITS, AND METHODS FOR TREATING AN INFECTION 审中-公开
    用于治疗感染的组合物，系统，试剂盒和方法

    公开(公告)号：WO2017180822A1

    公开(公告)日：2017-10-19

    申请号：PCT/US2017/027333

    申请日：2017-04-13

    Applicant: NOVAN, INC.

    Inventor： DOXEY, Ryan ,  STASKO, Nathan ,  MARTIN, Megan

    IPC: A61K9/10 ,  A61K31/80 ,  A61P17/02

    Abstract: Provided herein are compositions, systems, kits, and methods for treating a viral, bacterial, protozoan, and/or fungal (e.g., onychomycosis and/or tinea pedis) infection.

    Abstract translation: 本文提供了用于治疗病毒，细菌，原生动物和/或真菌（例如，灰指甲和/或足癣）感染的组合物，系统，试剂盒和方法。

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