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公开(公告)号:WO2021127456A1
公开(公告)日:2021-06-24
申请号:PCT/US2020/066040
申请日:2020-12-18
Applicant: RAIN THERAPEUTICS INC.
Inventor: WAGMAN, Allan S.
IPC: A61K47/54 , A61P35/00 , A61K47/545 , C07D239/94 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/10
Abstract: The present disclosure relates to prodrugs of pan-HER, HER2, HER4 and/or EGFR (HER1) inhibitory agents. The prodrugs can be covalently bonded to attenuating moieties such as reductive triggers (e.g., chemical moieties that can be cleaved in vivo). The prodrugs are useful in methods of treatment of the human or animal body.