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1.发明申请USE OF EIF-5A1 SIRNA TO PROTECT ISLETS CELLS FROM APOPTOSIS AND TO PRESERVE THEIR FUNCTIONALITY 审中-公开使用EIF-5A1 SIRNA来保护细胞免受凋亡和保护其功能公开(公告)号：WO2009026317A2
公开(公告)日：2009-02-26
申请号：PCT/US2008073642
申请日：2008-08-20
Applicant: SENESCO TECHNOLOGIES INC , THOMPSON JOHN E , DINARELLO CHARLES A
Inventor： THOMPSON JOHN E , DINARELLO CHARLES A
IPC: C12N5/02 , A61K31/713 , C12N5/071 , C12N5/10 , C12N15/113
CPC classification number: C12N5/0676 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12N2501/48
Abstract: The present invention relates to methods for improving the viability, recovery and functionality of islets that are separated from a donor organ for subsequent transplantation and more particularly relates to the use of eIF-5A1 siRNAs to enhance the viability and functionality of islets.
Abstract translation: 本发明涉及用于改善与用于随后移植的供体器官分离的胰岛的存活力，恢复和功能性的方法，更具体地涉及使用eIF-5A1 siRNA来增强胰岛的活力和功能性。
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2.发明申请
公开(公告)号：WO2007109677A3
公开(公告)日：2008-04-24
申请号：PCT/US2007064424
申请日：2007-03-20
Applicant: SENESCO TECHNOLOGIES INC
Inventor： THOMPSON JOHN E , DINARELLO CHARLES A
IPC: A61K31/7088 , C07K14/47 , C12N5/071 , C12N15/113
CPC classification number: A61K31/7088 , C12N5/0676 , C12N15/113 , C12N2310/14
Abstract: The present invention relates to methods for improving the viability and recovery of islets that are separated from a donor organ for subsequent transplantation and more particularly relates to the use of eIF5A siRNAs to enhance the viability of islets.
Abstract translation: 本发明涉及用于改善从用于随后移植的供体器官分离的胰岛的活力和恢复的方法，更具体地涉及使用eIF5A siRNA来增强胰岛的活力。
