公开(公告)号：WO2008063638A3

公开(公告)日：2008-09-18

申请号：PCT/US2007024255

申请日：2007-11-20

Applicant: SENORX INC ,  LUBOCK PAUL ,  JONES MICHAEL L ,  BROADAWAY ETHAN ,  LOUW FRANK R

Inventor： LUBOCK PAUL ,  JONES MICHAEL L ,  BROADAWAY ETHAN ,  LOUW FRANK R

IPC: A61B17/34 ,  A61B17/00 ,  A61B19/00

CPC classification number: A61B17/32 ,  A61B17/3417 ,  A61B17/3431 ,  A61B17/3468 ,  A61B17/3496 ,  A61B17/3498 ,  A61B90/39 ,  A61B2017/00477 ,  A61B2017/00911 ,  A61B2090/062 ,  A61B2090/3908 ,  A61B2090/3954 ,  A61B2090/3987

Abstract: An obturator (10) with an elongated shaft (11), a proximal end

Abstract translation: 具有细长轴（11），近端<12），基本上封闭的远端（14）和MRI可检测的远端轴部分（15）的闭塞器（10），其不干扰组织的磁共振成像 于此。 优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的，Tl加权的图像。

公开(公告)号：WO2009058186A2

公开(公告)日：2009-05-07

申请号：PCT/US2008011435

申请日：2008-10-03

Applicant: SENORX INC ,  JONES MICHAEL L ,  LOUW FRANK R

Inventor： JONES MICHAEL L ,  LOUW FRANK R

IPC: A61L29/06 ,  A61L29/14

CPC classification number: A61L29/18 ,  A61L29/06 ,  A61L29/085 ,  A61L29/14 ,  A61L2420/06 ,  C08L75/04

Abstract: The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material and finely divided particulate to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein.

Abstract translation: 本公开涉及辐射导管装置，用于受控地应用照射到身体部位的组织的方法，例如在去除组织后形成的空腔，例如， 癌症，使用这种辐射导管装置，用于形成更加光滑的腔表面的解决方案和用于衬里这些装置的流明以提高其摩擦特性的方法。 导管装置包括柔性细长轴，其由低硬度聚合物材料形成，其可以容易地折叠或卷绕以将轴固定到患者的皮肤上或皮下，并且内衬有高硬度聚合物材料和细碎颗粒 以提高摩擦特性。 细长轴具有用于接收辐射源的至少一个内腔，辐射源具有提供较低表面摩擦以便促进其中的辐射源的高硬度聚合材料层。

公开(公告)号：WO2004075719A3

公开(公告)日：2007-03-01

申请号：PCT/US2004005023

申请日：2004-02-20

Applicant: SENORX INC

Inventor： QUICK RICHARD L ,  LOUW FRANK R ,  LUBOCK PAUL ,  SHABAZ MARTIN V ,  SAFABASH JASON

IPC: A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B17/34

CPC classification number: A61B10/0275 ,  A61B17/32002 ,  A61B17/3417 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/0046 ,  A61B2017/00473 ,  A61B2017/3405 ,  A61B2017/3454 ,  A61B2090/0811

Abstract: The invention is directed to devices and methods for separating and collecting a tissue specimen form a patient's target site. The device includes a probe member and a penetrating distal tip and a tissue receiving aperture, and a tissue cutting member which is rotatable disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture. The longitudinal edges of the aperture are preferably sharpened to engage the cutting edges of the tissue cutting member. Vacuum may be provided in the inner lumen of the cutting member to transport the tissue therethrough. Rotation, rotational oscillation and/or longitudinal reciprocation of the tissue cutting member is effective to separate a tissue specimen from surrounding tissue. An accessing cannula having a tissue receiving aperture may be concentrically disposed within the probe member and about the tissue cutting member.

Abstract translation: 本发明涉及用于从患者的目标部位分离和收集组织标本的装置和方法。 该装置包括探针构件和穿透远侧末端和组织接收孔，以及组织切割构件，其可旋转地设置在探针构件内，以通过孔切割被拉入装置内部的组织样本。 孔的纵向边缘优选地被锐化以接合组织切割构件的切割边缘。 可以在切割构件的内腔中设置真空以将组织输送通过其中。 组织切割构件的旋转，旋转振动和/或纵向往复运动有效地将组织标本与周围组织分开。 具有组织接收孔的进入套管可以同心地设置在探针构件内并且围绕组织切割构件。

公开(公告)号：WO2006017400A8

公开(公告)日：2006-10-05

申请号：PCT/US2005027071

申请日：2005-07-29

Applicant: SENORX INC ,  SHABAZ MARTIN V ,  QUICK RICHARD L ,  LOUW FRANK R ,  LUBOCK PAUL ,  SAFABASH JASON H

Inventor： SHABAZ MARTIN V ,  QUICK RICHARD L ,  LOUW FRANK R ,  LUBOCK PAUL ,  SAFABASH JASON H

IPC: A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B17/34

CPC classification number: A61B10/0275 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/32002 ,  A61B17/3417 ,  A61B90/30 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/00473 ,  A61B2017/00486 ,  A61B2017/3405 ,  A61B2090/3908 ,  A61B2090/3987

Abstract: The invention is directed to a system and device for separating and collecting a tissue specimen from a patient target site. The device includes a probe component (11) with an elongated tubular section (15), a penetrating distal tip (16) and a tissue receiving aperture (17) in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member (20) which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The device has a driver component (12) to which the probe component is releasably secured. The driver has a drive member (22,23) for adjusting the orientation of the tubular section and one or more drive members (30) for moving the tissue cutting member within the tubular section to sever a tissue specimen. The motion imparted to the tissue cutter is at least longitudinal and preferably is also oscillation and/or rotational.

Abstract translation: 本发明涉及一种用于从患者靶位置分离和收集组织标本的系统和装置。 该装置包括具有细长管状部分（15）的探针部件（11），远侧末端的管状部分的远端中的穿透远端（16）和组织接收孔（17），以及组织 切割构件（20），其可滑动地设置在所述探针构件内，以通过对所述组织切割构件的内腔施加真空来切割通过所述孔被拉入所述装置的内部的组织样本。 该装置具有驱动器部件（12），探头部件可释放地固定到该部件上。 驱动器具有用于调节管状部分的取向的驱动构件（22,23）和用于移动管状部分内的组织切割构件以切断组织样本的一个或多个驱动构件（30）。 赋予组织切割器的运动至少是纵向的，并且优选地也是振动和/或旋转。

公开(公告)号：WO2008008089A3

公开(公告)日：2008-03-06

申请号：PCT/US2006044067

申请日：2006-11-13

Applicant: SENORX INC ,  LUBOCK PAUL ,  JONES MICHAEL L ,  LOUW FRANK R

Inventor： LUBOCK PAUL ,  JONES MICHAEL L ,  LOUW FRANK R

IPC: A61N5/10 ,  A61M36/04

CPC classification number: A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

Abstract: The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

Abstract translation: 本公开描述了用于在体腔或部位的不对称照射的装置和方法，例如在去除组织之后，例如， 活检或癌症。 一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射 （例如健康组织）。

公开(公告)号：WO2006017400A3

公开(公告)日：2006-05-18

申请号：PCT/US2005027071

申请日：2005-07-29

Applicant: SENORX INC ,  SHABAZ MARTIN V ,  QUICK RICHARD L ,  LOUW FRANK R ,  LUBOCK PAUL ,  SAFABASH JASON H

Inventor： SHABAZ MARTIN V ,  QUICK RICHARD L ,  LOUW FRANK R ,  LUBOCK PAUL ,  SAFABASH JASON H

IPC: A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B17/34

CPC classification number: A61B10/0275 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/32002 ,  A61B17/3417 ,  A61B90/30 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/00473 ,  A61B2017/00486 ,  A61B2017/3405 ,  A61B2090/3908 ,  A61B2090/3987

Abstract: The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component (11) with an elongated tubular section (15), a penetrating distal tip (16) and a tissue receiving aperture (17) in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member (20) which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The device also has a driver component (12) to which the probe component is releasably secured. The driver has a drive member (22,23) for adjusting the orientation of the tubular section and thus the aperture therein and one or more drive members (30) for moving the tissue cutting member within the tubular section to sever a tissue specimen from tissue extending into the interior of the tubular section through the aperture. The motion imparted to the tissue cutter is at least longitudinal and preferably is also oscillation and/or rotational to effectively separate a tissue specimen from tissue extending through the aperture in the tubular section.

Abstract translation: 本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。 该装置包括具有细长管状部分（15）的探针部件（11），远侧末端的管状部分的远端中的穿透远侧末端（16）和组织接收孔（17），以及组织 切割构件（20），其可滑动地设置在所述探针构件内，以通过对所述组织切割构件的内腔施加真空来切割通过所述孔被拉入所述装置的内部的组织样本。 该装置还具有驱动器部件（12），探针部件可释放地固定到该部件上。 驱动器具有用于调节管状部分的取向并因此调节其中的孔的驱动构件（22,23）和一个或多个驱动构件（30），用于移动管状区段内的组织切割构件以从组织切断组织样本 通过孔延伸到管状部分的内部。 赋予组织切割器的运动至少是纵向的，并且优选地也是振动和/或旋转以有效地将组织样本与延伸穿过管状部分中的孔的组织分离。

公开(公告)号：WO2005063126A3

公开(公告)日：2005-09-15

申请号：PCT/US2004043021

申请日：2004-12-20

Applicant: SENORX INC

Inventor： SHABAZ MARTIN V ,  QUICK RICHARD L ,  LOUW FRANK R ,  LUBOCK PAUL ,  SAFABASH JASON H

IPC: A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B17/34 ,  A61B19/00

CPC classification number: A61B10/0275 ,  A61B10/0283 ,  A61B17/32002 ,  A61B17/32053 ,  A61B17/3417 ,  A61B90/30 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/00207 ,  A61B2017/00473 ,  A61B2017/2911 ,  A61B2017/2925 ,  A61B2017/3405 ,  A61B2090/3908 ,  A61B2090/3987

Abstract: The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component which is releasably secured to the driver component (12). The probe component has an elongated tubular section (15), a penetrating distal tip (16) and a tissue receiving aperture (17) in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member (20) which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum (59) to the inner lumen of the tissue cutting member. The driver has drive members (22, 30, 40) for operating the elements of the probe component. The tissue penetrating distal tip preferably has a triple concave curvature shape with three curved cutting edges leading to a sharp distal point.

Abstract translation: 本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。 该装置包括可释放地固定到驱动器部件（12）的探针部件。 探针部件具有细长的管状部分（15），远侧末端的管状部分的远端中的穿透远端（16）和组织接收孔（17），以及组织切割构件（20） 可滑动地设置在所述探针构件内，以通过将真空（59）施加到所述组织切割构件的内腔来切割通过所述孔而被拉入所述装置的内部的组织样本。 驱动器具有用于操作探针部件的元件的驱动部件（22,30,40）。 组织穿透的远侧末端优选地具有三凹曲面形状，其具有三个弯曲的切割边缘，其导致尖锐的远端点。