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公开(公告)号：WO2020263733A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/038915
申请日：2020-06-22
Inventor： GAO, Jinming , WANG, Xu , TANG, Houliang , LI, Wei , WILHELM, Jonathan , SUMER, Baran
Abstract: The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo . In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug.
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公开(公告)号：WO2020243217A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/034783
申请日：2020-05-28
Inventor： GAO, Jinming , SUMER, Baran , ZHAO, Tian , BENNETT, Zachary, T.
IPC: C07C69/54 , C07C219/08 , C08F293/00 , G01N21/63 , G01N21/64 , G01N33/58
Abstract: Described herein are pH responsive compounds, micelles, and compositions useful for the detection of primary and metastatic tumor tissues. Compounds described herein are imaging agents useful for the detection of primary and metastatic tumor tissue (including lymph nodes). Real-time fluorescence imaging during surgery aids surgeon in the detection of metastatic lymph nodes or delineate tumor tissue versus normal tissue, with the goal of achieving negative margins and complete tumor resection.
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3.发明申请
公开(公告)号：WO2021217111A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/029046
申请日：2021-04-26
Inventor： GAO, Jinming , HUANG, Tongyi , FENG, Qiang , SUMER, Baran
IPC: A61K31/196 , A61K31/502 , A61K31/635
Abstract: Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.
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公开(公告)号：WO2013152059A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/035050
申请日：2013-04-03
Inventor： GAO, Jinming , ZHOU, Kejin , SUMER, Baran
IPC: A61K47/48
CPC classification number: A61K49/0054 , A61K49/0032 , A61K49/0082 , G01N21/6486 , G01N33/502
Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.
Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。
