公开(公告)号：WO2023283363A1

公开(公告)日：2023-01-12

申请号：PCT/US2022/036395

申请日：2022-07-07

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： JAIN, Abhishek ,  TRONOLONE, James, J. ,  SAHA, Biswajit

IPC: C12M3/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/04 ,  C12M1/12 ,  C12M3/04 ,  C12M3/06 ,  C12N5/00 ,  C12Q1/02

Abstract: In an embodiment, the present disclosure pertains to a medical device. In some embodiments, the medical device includes a first compartmentalized microfluidic channel flanked by two microchannels and a second compartmentalized microfluidic channel. In some embodiments, the first and second compartmentalized microfluidic channels are situated vertically one to another. In some embodiments, the medical device further includes a porous membrane situated between the first and second compartmentalized microfluidic channels. In another embodiment, the present disclosure pertains to an organ-on-chip. In some embodiments, the organ-on-chip includes a top portion having three parallel microchannels. In some embodiments, the three parallel microchannels are separated by micropillars. In some embodiments, the organ-on-chip further includes a bottom portion having a fourth microchannel and a membrane between the top portion and the bottom portion.