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公开(公告)号：WO2022235329A1
公开(公告)日：2022-11-10
申请号：PCT/US2022/018696
申请日：2022-03-03
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： XU, Peisheng , WANG, Mingming
IPC: A61K31/197 , A61K9/14
Abstract: Disclosed are brain-targeted antibody delivery systems, methods of forming the systems, and methods of using the systems. The systems include hydrophilic nanogels based upon poly(ethylene glycol) copolymers. The nanogels can encapsulate an antibody for delivery to the brain and can include ligands for blood brain barrier (BBB) receptors on the surface, and as such, can utilize a systemic route of administration for delivery of the antibody to the brain and the eye. The systems can be utilized for systemic delivery routes to deliver the antibody to the brain side of the blood brain barrier and inside glial cells and degrade its corresponding protein. The systems can be utilized in treatment of neurodegenerative or retinal disorders.
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公开(公告)号：WO2022005590A1
公开(公告)日：2022-01-06
申请号：PCT/US2021/029795
申请日：2021-04-29
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： XU, Peisheng
IPC: A61K47/62 , A61K47/69 , A61P35/00 , A61K39/00 , A61K2039/505 , A61K2039/55555 , A61K39/0011 , A61K47/64 , A61K47/6903 , A61K47/6933 , A61K47/6935 , A61K9/5146 , C08G69/10 , C08G69/26 , C08G69/48
Abstract: Described herein are systems and methods for the degradation of endogenous protein with the help of a nanocarrier, which has the advantage of easy scale-up and feasibility for in vivo application.
