公开(公告)号：WO2013133920A1

公开(公告)日：2013-09-12

申请号：PCT/US2013/024347

申请日：2013-02-01

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JOUDREY, Kurt ,  CORMIER, Sylvain ,  USOWICZ, James ,  BERG, Emily J. ,  SEITH, Christopher

IPC: F16L19/00

CPC classification number: F16L19/061 ,  G01N30/6026

Abstract: A fitting for coupling fluidic paths, such as high pressure fluidic paths in liquid chromatography systems, includes a compression nut, a tube assembly and a compression member. The compression nut has a threaded outer surface to engage a threaded bore of a receiving port and the tube assembly has an outer surface and an end face to contact a sealing surface of the receiving port. The compression member is pre-staked to the outer surface of the tube assembly at a predetermined distance from the end face and has a tapered surface to engage a surface of the receiving port. The predetermined distance permits the tube assembly to be inserted into the receiving port so that the end face makes contact with the sealing surface without the tapered surface engaging a surface of the receiving port and so that the threaded outer surface of the compression nut engages the threaded bore.

Abstract translation: 用于耦合流体路径（例如液相色谱系统中的高压流体路径）的配件包括压缩螺母，管组件和压缩构件。 压缩螺母具有螺纹外表面以接合接收端口的螺纹孔，并且管组件具有外表面和端面以接触接收端口的密封表面。 压缩构件预先固定在距离端面一预定距离的管组件的外表面上，并且具有锥形表面以接合接收端口的表面。 预定距离允许管组件插入到接收端口中，使得端面与密封表面接触，而锥形表面接合接收端口的表面，并且使得压缩螺母的螺纹外表面接合螺纹 孔。

公开(公告)号：WO2016164544A1

公开(公告)日：2016-10-13

申请号：PCT/US2016/026386

申请日：2016-04-07

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JACKSON, Michael, R. ,  SEITH, Christopher ,  BARRETT, Nathan ,  O'DONNELL, Kara ,  ALMEIDA, Neal, B. ,  LU, Wen ,  USOWICZ, James, E. ,  SOK, Maruth ,  JOUDREY, Kurt, D. ,  SHREVE, Joshua, A.

IPC: B01D15/08 ,  B01D15/18 ,  G01N30/30

CPC classification number: F25B25/005 ,  B01D15/40 ,  G01N30/30

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.

Abstract translation: 本公开涉及用于冷却泵头的方法，系统和装置，并且在多个泵头之间提供平衡的冷却和热传递。 用于泵送密度差异很大，温度变化很小的多泵系统，如基于CO2的色谱系统的流动相，需要高度稳定的温度条件。 为了实现多个泵头和冷却剂流体之间的基本相等的平均热传递，冷却剂流体可以循环和/或平行的冷却剂流动模式流过泵头内的冷却剂通道。 这种递归和/或平行的冷却剂流体流动模式提供通过多泵系统的流体的温度，压缩性和密度的增加的稳定性。

公开(公告)号：WO2016164542A1

公开(公告)日：2016-10-13

申请号：PCT/US2016/026383

申请日：2016-04-07

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JACKSON, Michael, R. ,  SEITH, Christopher ,  BALA, Senthil ,  FREDETTE, Colin

IPC: G01N33/30 ,  B01D15/16 ,  B01D15/40

CPC classification number: G01N30/84 ,  B01D15/24 ,  B01D15/40 ,  G01N30/30 ,  G01N30/32 ,  G01N30/62 ,  G01N30/80 ,  G01N30/82

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as C0 2 , and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.

Abstract translation: 本公开涉及用于冷却过饱和或混合相溶液以增加溶解于其中的气体的溶解度的方法，系统和设备。 在流体色谱系统中，流动相可以包括含有气体例如CO 2的加压混合物，并且在部分收集和/或检测之前，一部分气体通过气体/ 液体分离器。 冷却离开气/液分离器的基本上液相的洗脱液增加仍然溶解在洗脱液中的任何剩余气体的溶解度。 残余气体的溶解度增加可防止气体析出，提供更一致的流动通过系统的流动，并且导致对所需样品的更有效的收集和分析。