公开(公告)号：WO2021226043A1

公开(公告)日：2021-11-11

申请号：PCT/US2021/030600

申请日：2021-05-04

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： FOGWILL, Michael O. ,  CORMIER, Syvlain Gilles ,  SWANN, Thomas ,  TRACEY, Francis Patrick

IPC: G01N30/46

Abstract: Described are multidimensional liquid chromatography (MDLC) systems and methods of performing MDLC. The MDLC systems includes valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system. Various system embodiments are provided in a smaller instrument size, include an option to use the same detector for both first and second dimensions, enable improvement in valve timing operations and provide a reduction in the magnitude and effects of pressure pulses. In addition, the modulator can enable dilution of the analytes and enable incompatible mobile phases and mobile phase flow rates to be used in the first and second dimensions.

公开(公告)号：WO2021195027A1

公开(公告)日：2021-09-30

申请号：PCT/US2021/023596

申请日：2021-03-23

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： CORMIER, Syvlain Gilles ,  ANTOCCI, Joseph D. ,  TRACEY, Francis Patrick ,  PHOEBE, JR., Charles H.

IPC: G01N30/24 ,  G01N35/02 ,  G01N35/10 ,  G01N30/02 ,  G01N2030/027 ,  G01N2030/207 ,  G01N2035/00534 ,  G01N2035/0408 ,  G01N30/20 ,  G01N30/38 ,  G01N35/04 ,  G01N35/1072 ,  G01N35/1095

Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.