公开(公告)号：WO2023088671A1

公开(公告)日：2023-05-25

申请号：PCT/EP2022/080357

申请日：2022-10-31

Applicant: TECHNISCHE UNIVERSITÄT MÜNCHEN

Inventor： DI CARLO, Daniel ,  WESTER, Hans-Jürgen

IPC: C07B59/00 ,  C07F5/00 ,  A61K51/04 ,  A61K51/08

Abstract: Provided is a method for the preparation of a composition comprising dissolved [18F]fluoride ions which is suitable for radiofluorination, said method comprising the steps of - providing an aqueous solution comprising water and [18F]fluoride ions; - passing the aqueous solution through a solid phase extraction device comprising an anion exchange resin in order to trap [18F]fluoride ions on the anion exchange resin and to separate the [18F]fluoride ions trapped on the anion exchange resin from water; - eluting [18F]fluoride ions from the anion exchange resin by passing an elution composition comprising an organic solvent and a salt of an alkanoic acid through the solid phase extraction device; - obtaining a composition as an eluate which comprises the organic solvent, the salt of the alkanoic acid, and dissolved [18F]fluoride ions. Moreover, provided are the composition comprising dissolved [18F]fluoride ions, and a method for the preparation of a radiofluorinated organic compound, which involves the preparation of the composition comprising dissolved [18F]fluoride ions.

公开(公告)号：WO2023073603A1

公开(公告)日：2023-05-04

申请号：PCT/IB2022/060331

申请日：2022-10-27

Applicant: NOVARTIS AG ,  ADVANCED ACCELERATOR APPLICATIONS

Inventor： AIMONE, Paola Daniela ,  CHICCO, Daniela ,  MARIANI, Maurizio F. ,  ZOR, Evren

IPC: A61K51/08 ,  A61P35/00 ,  A61K103/00 ,  A61K103/30

Abstract: The present disclosure is directed to a method of treating glioblastoma in a subject in need thereof comprising administering to said subject an efficient amount of a radiopharmaceutical compound. The present disclosure is also directed to methods of treating glioblastoma in a subject in need thereof comprising administering to said subject an efficient amount of a radiopharmaceutical compound in combination with a step of irradiating the subject with an efficient dose of ionizing radiations, and optionally, with a therapeutically efficient amount of an alkylating agent, preferably temozolomide.

公开(公告)号：WO2023060317A1

公开(公告)日：2023-04-20

申请号：PCT/AU2022/051236

申请日：2022-10-14

Applicant: CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY ,  UNIVERSITY OF SYDNEY

Inventor： HOGG, Philip ,  HO SHON, Ivan

IPC: C07B59/00 ,  A61K51/04 ,  A61K51/08 ,  A61P35/00

Abstract: The disclosure relates to a radiolabelled conjugate of a trivalent arsenical compound, the use of such a radiolabelled conjugate in the diagnosis and treatment of conditions associated with cell death, such as neoplastic conditions, and processes for preparing such a radiolabelled conjugate.

公开(公告)号：WO2023019303A1

公开(公告)日：2023-02-23

申请号：PCT/AU2022/050905

申请日：2022-08-16

Applicant: CLARITY PHARMACEUTICALS LTD

Inventor： MCINNES, Lachlan Eion ,  DONNELLY, Paul Stephen ,  IRONSIDE, Michael David

IPC: C07B59/00 ,  C07K7/08 ,  A61K51/08 ,  A61P35/00

Abstract: The present invention relates to compounds that can complex a radionuclide and formulations and kits comprising compounds that can complex a radionuclide. The compounds, formulations and kits are of use in radiotherapy and diagnostic imaging.

公开(公告)号：WO2023015204A1

公开(公告)日：2023-02-09

申请号：PCT/US2022/074463

申请日：2022-08-03

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： BEHNAM AZAD, Babak

IPC: C07K7/06 ,  A61K38/10 ,  A61K101/00 ,  A61K51/08 ,  C07K7/00

Abstract: The present disclosure provides agents for detecting cancer based on peptides derived from thymosin beta-10 (Tβ-10) and compositions and methods of use thereof. Particularly, the disclosure provides agents comprising a peptide derived from thymosin beta-10 (Tβ-10) covalently attached to an imaging agent, wherein the peptide comprises less than 20 amino acids and methods of detecting, diagnosing, or imaging cancer.

公开(公告)号：WO2023014968A1

公开(公告)日：2023-02-09

申请号：PCT/US2022/039568

申请日：2022-08-05

Applicant: HISTOWIZ, INC.

Inventor： CHENG, Ke ,  WILDER, Matthew

IPC: A61K51/08 ,  A61K49/00

Abstract: Provided herein are methods and systems for performing an automated quality control analysis of digital micrographs representing slides with tissue samples. An automated quality control analysis may comprise analyzing digital micrographs of histology slides for gross errors and excessive regions of blurriness.

公开(公告)号：WO2023012282A1

公开(公告)日：2023-02-09

申请号：PCT/EP2022/071964

申请日：2022-08-04

Applicant: TECHNISCHE UNIVERSITÄT MÜNCHEN

Inventor： PARZINGER, Mara ,  WENDLINGER, Lennard ,  WESTER, Hans-Jürgen

IPC: A61K51/04 ,  A61K51/08 ,  C07B59/00 ,  C07F7/12

Abstract: Provided is a compound selected from (a) a compound of formula (I) wherein a is 0 or 1; m is 2 or 3; n is 2 or 3; one group selected from R1, R2 and R3 is a group comprising an effector moiety RB; another group selected from R1, R2 and R3 is a group comprising a silicon-based fluoride acceptor (SiFA) moiety Rs; and the remaining group selected from R1, R2 and R3 is a group of the formula (R-1) wherein R4 is selected from -H, -OH and C1-C3 alkyl; and wherein the dashed line marks a bond which attaches the group to the remainder of the compound; R5 is selected from -H, -OH and C1 -C3 alkyl; (b) a salt thereof, and (c) a chelate compound formed from a compound of formula (I) or its salt, and a radioactive or non-radioactive cation. The compounds of the invention are suitable for therapeutic and diagnostic purposes such as radionuclide therapy or nuclear diagnostic imaging.

公开(公告)号：WO2022260483A1

公开(公告)日：2022-12-15

申请号：PCT/KR2022/008236

申请日：2022-06-10

Applicant: 서강대학교산학협력단

Inventor： 지대윤 ,  오금록

IPC: A61K51/08 ,  C07B59/00 ,  C07K7/06 ,  C07K7/64

Abstract: 본 발명에 따른 상기 화학식 1의 18F-ApoPep-7은, 18F-ApoPep-1의 유도체로, 방사성동위원소인 F-18을 높은 방사화학적 수율과 방사화학적 순도, 높은 비방사능으로 표지할 수 있는 제조상의 장점이 있다. 따라서 본 발명의 18F-ApoPep-7을 양전자방출 단층촬영술 영상의약품으로 사용시 세포사멸과 관련된 다양한 질병 진단에 적용될 수 있다.

公开(公告)号：WO2022232943A1

公开(公告)日：2022-11-10

申请号：PCT/CA2022/050712

申请日：2022-05-06

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： WHARTON, Luke ,  ORVIG, Chris

IPC: C07D213/79 ,  A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  C07K14/00 ,  C07K16/00

Abstract: A chelator having the general structure (I) wherein each R1 is independently OH, NH or SH, and X is O, S, or NR3, wherein R3 is H or CH2C(=O)R1. Methods of making and using the chelator, metal chelates, and biological constructs for delivering targeted radiation therapy using the chelator are provided. (I).

公开(公告)号：WO2022232124A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/026318

申请日：2022-04-26

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

Inventor： MORSE, David ,  JI, Haitao ,  WADAS, Thaddeus

IPC: A61K51/08

Abstract: Disclosed are TATE derivatives having a linker between the TATE moiety and a macrocyclic radionuclide chelating moiety. Methods of synthesis and use are also disclosed. The compounds preferably exhibit a ratio of kidney:liver uptake by a subject within 24 hours of 5 or less, 3 or less, 1 or less, 0.5 or less, preferably from 2:1 to 1:2.