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    MICROFLUIDIC DEVICES
    1.
    发明申请
    MICROFLUIDIC DEVICES 审中-公开

    公开(公告)号：WO2023083455A1

    公开(公告)日：2023-05-19

    申请号：PCT/EP2021/081433

    申请日：2021-11-11

    Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

    Inventor： PARK, Jisoo ,  LÜTOLF, Matthias

    IPC: C12M3/06

    Abstract: The present disclosure relates to a microfluidic device comprising: a substrate; a culture chamber (130); a loading channel (170) in fluid communication with the culture chamber; at least one auxiliar channel (170-1, 5 170-2) extending from and in fluid communication with the loading channel, wherein the at least one auxiliary channel is so dimensioned such that a hydraulic resistance in the at least one auxiliary channel is higher than a hydraulic resistance in the loading channel; a test area (150) defined along the loading channel at a position between the loading channel and the at least one auxiliary channel; a first medium reservoir (110) in fluid communication with a first side of the test area; and a second medium reservoir (120) in fluid communication with a second side of the test area, the second side being different from the first side.

    MICROFLUIDIC SYSTEM FOR ROBUST LONG-TERM ELECTRICAL MEASUREMENT AND/OR STIMULATION OF CELL CULTURES
    2.
    发明申请
    MICROFLUIDIC SYSTEM FOR ROBUST LONG-TERM ELECTRICAL MEASUREMENT AND/OR STIMULATION OF CELL CULTURES 审中-公开

    公开(公告)号：WO2023067120A1

    公开(公告)日：2023-04-27

    申请号：PCT/EP2022/079336

    申请日：2022-10-21

    Applicant: ALPVISION S.A. ,  FINALSPARK SARL

    Inventor： COMBY, Jean-Marc ,  MOR, Flavio ,  KUTTER, Martin ,  JORDAN, Frédéric

    IPC: C12M3/06 ,  C12M1/12 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36

    Abstract: A microfluidics system to maintain alive and control cell cultures such as neuronal cell cultures over an air-liquid interface is arranged to prevent the formation of air bubbles and liquid overflows in fully automated 24/7 operation over the mid-long term. A pumping device is adapted to push a liquid through an inlet (131) of the microfluidics channel (130), then through an area of the microfluidics channel that is under the air-liquid interface, then through an outlet (132) of the microfluidics channel, assisted with geometrical arrangements of the microfluidics channel outlet and optionally inlet placements relative to the porous membranes of the air-liquid interface. The pumping device may be programmed with different flow rates, flow directions, and flow durations according to cell culture features and events detected with a computer vision system and/or an electrophysiological signal processing system to automatically adapt the parameters of the pumping device to the current state of the cell culture (100) over the air-liquid interface.

    INCUBATOR WITH SHAKING MECHANISM
    8.
    发明申请
    INCUBATOR WITH SHAKING MECHANISM 审中-公开

    公开(公告)号：WO2022268828A1

    公开(公告)日：2022-12-29

    申请号：PCT/EP2022/066909

    申请日：2022-06-21

    Applicant: LICONIC AG

    Inventor： MALIN, Cosmas

    IPC: C12M1/00 ,  C12M3/06 ,  C12M1/36 ,  C12M23/50 ,  C12M27/16 ,  C12M41/14 ,  C12M41/48

    Abstract: An incubator for sample containers comprises a climate-controlled chamber (6) with several storage racks (16a - 16d) located therein. Shaker units (20a, 20b) are provided for shaking the storage racks, each of them carrying several storage racks (16a - 16d). A robot unit (26) accesses the storage locations (18) in the storage racks (16a - 16d) as well as an automated access door (44) at the back of the chamber (6). A user door (42) is located at the front of chamber (6). The shaker units (20a, 20b) and the storage racks (16a - 16d) are arranged on opposite sides of a vertical plane (48) extending perpendicularly to the doors (42, 44).

    다중 장기 모델
    9.
    发明申请
    다중 장기 모델 审中-公开

    公开(公告)号：WO2022265352A1

    公开(公告)日：2022-12-22

    申请号：PCT/KR2022/008401

    申请日：2022-06-14

    Applicant: 연세대학교 산학협력단

    Inventor： 조승우 ,  최보방 ,  김수겸 ,  김수란 ,  배중호

    IPC: C12N5/071 ,  C12N5/077 ,  C12M3/00 ,  G01N33/50 ,  C12M3/06 ,  C12M1/00

    Abstract: 본 발명은 다중장기모델에 관한 것으로 본 발명의 다중장기모델은 각 장기 오가노이드의 연결 상태 및 하이드로젤의 특성을 통해 각 장기 오가노이드의 배양이 우수할 뿐만 아니라, 생체 내 장기들 사이의 상호작용 및 미세환경을 더욱 정확하게 반영할 수 있다. 또한, 여기에 유리 지방산 처리를 더하여, 비알코올성 지방간의 표현형을 더욱 정확하게 모사할 수 있고 이를 통한 후보약물들의 주변장기의 영향까지 분석할 수 있는 효과가 있다.

    DEVICE AND METHOD FOR PREPARING COMPARTMENTALIZED IN VITRO MODELS WITH AN ELONGATED COMPONENT OF A BIOLOGICAL MATERIAL
    10.
    发明申请
    DEVICE AND METHOD FOR PREPARING COMPARTMENTALIZED IN VITRO MODELS WITH AN ELONGATED COMPONENT OF A BIOLOGICAL MATERIAL 审中-公开

    公开(公告)号：WO2022261775A1

    公开(公告)日：2022-12-22

    申请号：PCT/CA2022/050967

    申请日：2022-06-16

    Applicant: 9493662 CANADA INC.

    Inventor： GEORGE, Subin Mac ,  MAGDESIAN, Margaret Haiganouch

    IPC: C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M1/42 ,  C12M3/06 ,  C12N5/00 ,  C12Q1/02

    Abstract: There are provided cell culture devices and associated methods for preparing a compartmentalized in vitro model. The cell culture device can include a cell culture layer that includes an inlet reservoir configured for receiving an inlet fluid medium therein, an outlet reservoir configured for receiving an outlet fluid medium therein, and a channel extending between the inlet reservoir and the outlet reservoir to establish fluid communication therebetween. The channel can include a multicellular component receiving portion and an elongated component receiving portion provided downstream of the multicellular component receiving portion, the elongated component receiving portion being sized and configured for orienting an elongated component of a biological material away from the inlet reservoir. The cell culture device can further include an electrode layer provided in proximity of the cell culture layer.

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