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发明授权
CN100586475C 戊型肝炎口服疫苗及其制备方法 失效 - 权利终止

戊型肝炎口服疫苗及其制备方法
摘要：
一种用于预防戊型肝炎的戊型肝炎口服疫苗，其特征在于含有2-6×109CFU活菌和辅料，该活菌是将编码戊型肝炎病毒中和抗原表位的基因片段与质粒pYA3341进行重组，再将该重组质粒转化减毒鼠伤寒沙门菌(attenuatedSalmonella enterica serotype Typhimurium)。制备所述戊型肝炎口服疫苗的方法，其特征在于将编码戊型肝炎病毒中和抗原表位的优选基因片段与质粒pYA3341进行重组，再将该重组质粒转化减毒鼠伤寒沙门菌(attenuated Salmonella entericaserotype Typhimurium)。本发明提供一种安全、高效、低成本、方便易行的戊型肝炎口服疫苗及其制备方法。
摘要（英）：

The invention relates to a hepatitis-E oral vaccine, wherein it contains 2-6*109CFU bacterial and findings; said bacterial is prepared by recombining the gene section of hepatitis-E virus that neutralizes the represent part of antigen, with the pYA3341, then transferring said recombined particle into attenuated Salmonella enterica serotype Typhimurium. The inventive production is characterized inaforementioned process. And it has low cost and high safety.

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