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发明公开
CN101003541A 一种广谱抗菌化合物及其用途 无效 - 撤回

一种广谱抗菌化合物及其用途
摘要：
一种广谱抗菌化合物及其用途，具体涉及6－氟－1－甲基－4－氧代－7－(1－哌嗪基)－4H－[1，3]噻嗪[3，2－a]喹啉－3－羧酸葡萄糖酸盐和制备方法及其用途。它是由6－氟－1－甲基－4－氧代－7－(1－哌嗪基)－4H－[1，3]噻嗪[3，2－a]喹啉－3－羧酸和葡萄糖酸反应得到的化合物I，其用途是化合物I作为有效成分，与常规药用载体制成广谱抗菌药物组合物，可以是片剂、胶囊剂、颗粒剂、注射剂、眼用制剂、耳用制剂、妇科用制剂、皮肤外用制剂等。本发明提供的化合物I性质稳定，在水中易溶，可以方便地制备成各种剂型用于临床，增加了广谱抗菌药物制剂新品种。其生产工艺简便、合理，生产成本低。
摘要（英）：

This invention relates to an antibacterial compound, more specifically, 6-fluoro-1-methyl-4-oxo-7-(1-piperazine)-4H-[1, 3] thiazine [3, 2-a] quinoline-3-carboxylic glyconate (compound I), its preparation method and its application. Compound I is prepared by reaction of 6-fluoro-1-methyl-4-oxo-7-(1-piperazine)-4H-[1,3]thiazine[3,2-a]quinoline-3-carboxylic acid and gluconic acid. Compound I can be used as effective component and mixed with normal pharmaceutical carrier to manufacture antibacterial drug composition, which can be tablets, capsules, granules, injection, eye preparations, ear preparations, gynecological preparations, and external use preparations. Compound I has stable properties, and can be easily dissolved in water, thus can be easily manufactured into various preparations used in clinical treatment. The method has such advantages as simple and reasonable process.

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