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发明公开
CN101014589A 作为选择性黑色素聚集激素拮抗剂的新型杂环和其用于治疗肥胖症及相关疾病 无效 - 撤回

作为选择性黑色素聚集激素拮抗剂的新型杂环和其用于治疗肥胖症及相关疾病
摘要：
本发明公开了式(I)化合物，其中m、n、p、R1、R2和X在此处确定，所述的化合物是黑色素聚集激素(MCH)的新型拮抗剂，以及制备该类化合物的方法。在另一个实施方案中，本发明公开了包含此MCH拮抗剂的药物组合物，以及使用其治疗肥胖症、代谢性疾病、进食障碍疾患如饮食过量和糖尿病的方法。
摘要（英）：

The present invention discloses compounds of formula (I) wherein m, n, p, R1, R2 and X, are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

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