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发明公开
CN101037691A 一个CENP－E结合蛋白及其编码基因与应用 失效 - 权利终止

一个CENP－E结合蛋白及其编码基因与应用
摘要：
本发明公开了一个CENP－E结合蛋白及其编码基因与应用。其目的是提供一个CENP－E结合蛋白及其编码基因与其在制备抑制肿瘤增殖药物中的应用。该蛋白是下述氨基酸序列之一：1)序列表中的SEQ ID NO：1；2)将序列表中SEQ ID NO：1的氨基酸残基序列经过一至十个氨基酸残基的取代、缺失或添加且与CENP－E蛋白结合对细胞有丝分裂的行进具有调控功能的蛋白质。该蛋白通过与CENP－E和微管的相互作用参与细胞有丝分裂的纺锤体检查点信号转导途径，可以其为活性成分作为调控肿瘤细胞增殖的药靶，本发明的蛋白及其编码基因将在医学及制药领域发挥重要作用，应用前景广阔。
摘要（英）：

The invention discloses a CENP-E binding proteins, coding gene thereof and application therefor. The objective is to provide a CENP-E binding proteins, coding gene thereof and application in preparing medicine for repressing tumour proliferation. The protein is one amino acid sequence of followings: 1) SEQ ID NO: 1 in sequence form; 2) protein for substituting, absenting or adding one to ten amino acid residue to SEQ ID NO: 1 in sequence form and combining with CENP-E proteins to regualte mitotic cell. The protein reacts with CENP-E and micropipe to participate control point transduction pathway of cell mitotic spindle, using thereof as active component as drug targets for regulating tumour cell proliferation, the proteins and coding gene of the invention have improtant function in medicine and pharmacy field with widely application foreground.

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