The invention provides a compound which is indicated by a formula (I) which has the histamine H3 receptor antagonistic function or the histamine H3 receptor anti-excitement function and can be used for the prevention or the treatment of the diseases of the metabolic system, the diseases of the circulatory system or the diseases of the nervous system and the medical salt, [ in the chemical formula (1), X, Y, Z and W are respectively independent to represent methylene with substituted group; A, B and D are respectively independent to represent -C(O)- and so on; Q represents methylene or nitrogen atom, R represents a formula (II-1) which can be substituted by lower alkyl etc., (in the formula (II-1) , R6 represents the lower alkyl etc., R7 and R8 are respectively independent to represent lower alkyl etc.)].