The invention discloses a magnetic hollow microsphere with ferromanganese, and method for making it and the application. The materials of magnetic nucleus/shell compound microphere are polyphenylacetylene microphere, bivalent manganese salt, bivalent ferric salt, coring agent and precipitating agents. They are blend with certain quality, and the compound grain with polyphenylacetylene - containing manganese ferric oxygen shell can be obtained in fit temperature and mixing state. In nitrogen atmosphere, the organic core of core/shell sphere (polyphenylacetylene) is burned out, and magnetic hollow microsphere with ferromanganese can be obtained. The hollow microsphere produced by invention has good magnetism, and certain surface can not be oxygenized easily, and it can be used as the drug carrying agent target in iatrology, biology, industry application and so on, and it has wide application prospect.