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发明公开
CN101092597A 生产林可霉素用复合培养基及提高产量和质量的生产方法 失效 - 权利终止

生产林可霉素用复合培养基及提高产量和质量的生产方法
摘要：
本发明涉及一种生产林可霉素用复合培养基及提高产量和质量的生产方法，可有效解决林可霉素生产用复合培养基及提高产量和质量问题，其培养基是由玉米粉、玉米淀粉、乳酸钙、α－淀粉酶、糖化酶、蛋白酶制成，添加蛋氨酸或蛋氨酸钠或蛋氨酰胺制成，提高林可霉素产量与质量的方法是，利用复合培养基，加水稀释，调pH值，加入蛋氨酸或蛋氨酸钠或蛋氨酰胺，培养发酵即可，本发明提高产量14％，降低成本15％；林可霉素成品中林可霉素B组分含量低至1.0％以下，毒副作用低，被广泛用于医疗及畜牧业和林可霉素衍生产品克林霉素、克林霉素磷酸酯、克林霉素棕榈酸酯的起始原料。
摘要（英）：

This invention relates to a composite culture medium for producing lincomycin, and a method for increasing productivity and quality of lincomycin. The composite culture medium is prepared from: corn powder, cornstarch, alpha-amylase, glucoamylase, protease, and methionine or sodium methionine or methioninamide. The method comprises: diluting the composite culture medium with water, adjusting the pH value, adding methionine or sodium methionine or methioninamide, and fermenting. The method can increase lincomycin productivity by 14%, and reduce the cost by 15%. The lincomycin product has a low lincomycin B content (below 1.0%), and low toxic or side effect, thus can be used as a starting material for producing lincomycin derivatives, lincomycin phosphate and lincomycin palmitate used in medical field and animal husbandry.

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