The invention provides oligopeptide RGT, which can affect the platelet function, and the decoration object/ ramification, as well as the application of the oligopeptide RGT and the decoration object/ ramification in the field for preventing and /or treating artery thrombus type disease and / other the disease related with the external inner signal transmission of Integrin Beta 3. For the plateletafter being processed by the oligopeptide RGT or the decoration object/ ramification, the respects related with the external-inner signal transmission of the Integrin are reduced, and the internal-outer signal transmission is basically not affected. The non-return collecting forming of the platelet is stopped. The invention reduces the platelet activity, and prevents stable thrombus from forming,and synchronously keeps the partial adherence and collecting ability, thereby preventing the thrombus from forming, and basically keeping partial norm blood stopping function.