The invention provides a derivative containing 4-methyl-1, 2, 3-thiadiazole, a relative synthesis method and an application. The invention relates to a heterocyclic compound containing 1, 2-diazole, in particular to 4-methyl-1, 2, 3-thiadiazole, which are represented as above, wherein R1 is the naphthenic group of C1-C6 as cyclohexyl, cyclopenty and n propyl, R2 is substituted phenyl as phenyl, 2-fluorophenyl, 2-trifluoromethylphenyl, 2-nitrophenyl, 3-fluorophenyl, 3-trifluoromethylphenyl, 3-nitrophenyl, 4-chlorophenyl, 4-fluorophenyl, 4-hydroxyphenyl, 4-trifluoromethylphenyl and 2, 6-dichlorophenyl or the like, R3 is the naphthenic group of C1-C6 as cyclohexyl. The invention discloses the chemical structures of the compounds, relative synthesis methods and the prevention effect on agriculture disease pest and weed and the application for inducing plant to generate anti-disease effect in agriculture field. The invention also discloses the combination of the compounds, commercial antivirus medicine and fungicide for preventing agriculture and horticulture virus and pathogen.