The invention discloses a manufacturing method of low-segregation large-scale steel ingots obtained by accelerating the cooling of the bottom part and the side wall and relates to the manufacturing process of various levels of large-scale steel ingots, which is applicable to the control of the segregation of various components of carbon steel and alloy steel ingots and can be used for the castingprocess of vacuum pouring and non-vacuum pouring steel ingots, the control of the macro-segregation and the alleviation of the micro-segregation. The specific steps of the invention are that: 1) steel ingot mold material is a gray cast iron; 2) a riser adopts an insulated riser, the taper thereof is 8 to 16 percent; 3) the height-to-diameter ratio of the steel ingot is 1: 1 to 3: 1; 4) the steel ingot material is the carbon steel or the alloy steel; 5) an aeration conduit is pre-casted in the middle and lower part of the steel ingot mold and a chassis of the steel ingot mold; 6) the chassis starts the aeration of compressed air after the steel ingot pouring is finished, and the aeration of the compressed air on the side wall of the steel ingot mold can be carried out after 1 to 6 hours. Acooling system with the aeration of the compressed air at the chassis of the large-scale steel ingot and the side wall of the ingot mold designed by the invention can greatly improve the cooling speed of the large-scale steel ingot and effectively inhibit various segregations of the large-scale steel ingot.