The invention provides a method for producing a printing rotary screen with large mesh number, in particular to a method for producing a printing rotary screen with the mesh number of 205-405, which is mainly used for producing the rotary screen and belongs to the printing rotary screen production field. The method is simple, easy in operation and effective in controlling the percentage of open area and thickness in the condition of the same mesh, no joint exists, the stability is good, the printed ink thickness is even in printing, the printing quality is good, and the service life of the screen is prolonged.