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发明公开
CN101300234A 蛋白激酶抑制剂 失效 - 放弃专利权

蛋白激酶抑制剂
摘要：
本发明提供了二取代的嘧啶或吡啶化合物、包含这类化合物的药物组合物和使用这类化合物来治疗或预防与激酶活性异常或失控有关的疾病或紊乱、特别是涉及Lck、IR、IGF－1R、JNK1α、Flt3、Fes、EFGR(Her－1、erbB－1)、cSRC、CDK1/细胞周期蛋白B、c－RAF、BTK、Bmx、Axl、Aurora－A、Abl、BCR－Abl、TrkB、Tie2、Syk、SGK、SAPK2a、Rsk1和Met激酶异常激活的疾病或紊乱的方法。
摘要（英）：

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Lck, IR, IGF-1R, JNK1 , Flt3, Fes, EFGR (Her-1, erbB-1), cSRC, CDK1/cyclinB, c-RAF, BTK, Bmx, Axl, Aurora-A, Abl, BCR-Abl, TrkB, Tie2, Syk, SGK, SAPK2a, Rsk1 and Met kinases.

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