The invention provides a novel method for absorption and separation of high-purity chlorogenic acid, comprising an absorption process, an impurity cleaning process and an elution process. The method is characterized in that: after chlorogenic acid stock solution is dynamically absorbed by at least dual tandem absorption column which is filled with macroporous resins until penetration, impurity removal solution is added for impurity removal; and finally eluent is used for elution until no chlorogenic acid flows out, and effluent is collected. The purity of the pure chlorogenic acid solution obtained by the method can reach over 92 percent as shown by HPLC detection, and the concentration can reach between 0.1 and 0.8 milligram per milliliter; and the pure chlorogenic acid solution can be widely applied in the fields such as foodstuff, medicines, cosmetics and so on. Solid, namely dried chlorogenic acid powder, obtained after direct drying of the pure chlorogenic acid solution prepared by the method, does not require reprocessing, can be directly applied, and is convenient for conveying.