The invention discloses a loop-mediated isothermal amplification quick detection technology for a highly pathogenic blue ear disease. By using a special primer and utilizing a special region of a loop-mediated isothermal amplification technology (RT-LAMP) platform amplification target sequence, a highly pathogenic blue ear virus nucleic acid is detected from molecular level with the assistance ofa series of quality control, negative contrast and positive contrast. The method has the characteristics of simplicity, convenience, economization, quickness, sensitivity and specificity, and has broad application prospect.