The present invention relates to a closed electric submersible pump production well completion system which can process for steel wire operation. The closed electric submersible pump production well completion system comprises a production plug-in head, a closed electric submersible pump assembly, a blanking plug, a ball cup short section, etc. The closed electric submersible pump assembly comprises an air guide sleeve, a guide head, an oil pipe, an electric submersible pump set and a closed electric submersible pump hanger assembly. The closed electric submersible pump hanger assembly is an integral structure. A lower main pipe and a lower lateral pipe are arranged in the closed electric submersible pump hanger assembly and are extended into the air guide sleeve. The lower lateral pipe is connected with the electric submersible pump set. The lower main pipe is connected with the guide head and forms a column jacket steel wire operating passage. The closed electric submersible pump hanger assembly is connected with a full bore reverse circulation sub. The closed electric submersible pump production well completion system has the advantages that the steel wire operation and the production test can be processed in a column jacket during the production period; the closed electric submersible pump production well completion system is fit for the multi-completion and the selection completion of multiple producing formations; the system is matched with an oil layer protection valve to be used, thereby not only being capable of realizing the closed electric submersible pump production but also being capable of reducing the pollution to an oil layer during the well completion and workover period and improving the oil well productivity.