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发明公开
CN101341870A 武夷菌素可控缓释纳米微球的制备及其应用 无效 - 撤回

武夷菌素可控缓释纳米微球的制备及其应用
摘要：
武夷菌素可控缓释纳米微球的制备方法。其工艺步骤是：(1)将0.01％－1％的武夷菌素(a.i)加入到含0.05％－0.02％的壳聚糖、0.0875％－0.35％的醋酸的水溶液中，搅拌均匀制得溶液A。(2)将0.042％－0.25％的TPP(壳聚糖与TPP质量比为4∶1，4.5∶1，5∶1，5.5∶1，或6∶1)溶解于水溶液中，制得溶液B。(3)将B缓慢滴加到A中(A与B的体积比为5∶1)，以300r/min的转速搅拌30min制得载药量20％－30％的80－90nm武夷菌素可控缓释纳米微球，包裹率达100％。武夷菌素可控缓释纳米微球延长相同剂量药物的持效期，提高了药物的利用率，减少了用药量，最终降低成本，为武夷菌素推广应用提供一种新方法。
摘要（英）：

The invention relates to a preparation method of wuyiencin controllable sustained-release nano microspheres; the process steps are as follows: (1) 0.01 percent to 1 percent of wuyiencin (a.i) is added into aqueous solution which contains 0.05 percent to 0.02 percent of chitosan and 0.0875 percent to 0.35 percent of acetic acid to be stirred evenly, and solution A is prepared; (2) 0.042 percent to 0.25 percent of TPP (the mass ratio of chitosan to TPP is 4:1, 4.5:1, 5:1, 5.5:1 or 6:1) is dissolved in the aqueous solution, to obtain solution B; (3) B is slowly dripped to A (the volume ratio of A to B is 5:1), to be stirred for 30min at the rotating speed of 300r/min, to obtain 80cm to 90cm wuyiencin controllable sustained-release nano microspheres with 20 percent to 30 percent of drug load, and the encapsulation rate reaches 100 percent. The wuyiencin controllable sustained-release nano microspheres prolong the effect period of medicine with the same dosage, improve the utilization rate of the medicine, reduce the dosage, finally reduce the cost, and provide a novel method for promoting and applying wuyiencin.

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