The invention provides a laser processing system with a multi-axle numerical control and double worktables, comprising a machine tool body, a laser power supply arranged on the machine tool body, a water chilling unit used for cooling the laser power supply and a laser device arranged on the machine tool body. The laser processing system also comprises a first four-axle numerical control worktable which is arranged on the machine tool body and used for laser welding and cut processing, a second four-axle numerical control worktable which is used for laser cladding and heat treatment processing, a first laser processing head arranged on the first four-axle numerical control worktable and a second laser processing head arranged on the second four-axle numerical control worktable. The laser produced by the laser device is sent to the first laser processing head and the second laser processing head through a laser external light path. The laser processing system can conveniently make the same CO2 laser bundle separately switch to the required worktable through the two-way light beam guide unit of the laser lateral light path, and so compared with the prior laser processing system, the laser processing system can realize the three -dimensional processing and multi-procedure processing.